Tissue Distribution, Pharmacokinetics, and Effect of Hematological and Biochemical Parameters of Acute Intravenous Administration of Silver Nanoparticles in Rats.
Saved in:
| Title: | Tissue Distribution, Pharmacokinetics, and Effect of Hematological and Biochemical Parameters of Acute Intravenous Administration of Silver Nanoparticles in Rats. |
|---|---|
| Authors: | Salim, Elsayed I.1 (AUTHOR) elsayed.salim@science.tanta.edu.eg, Abdel-Halim, Khaled Y.2 (AUTHOR) khaled_yassen68@yahoo.com, El-Mahalawy, Mostafa E.1 (AUTHOR) melmehlawy@yahoo.com, Badr, Haitham A.3 (AUTHOR) egy.hab@gmail.com, Ahmed, Hafiz4 (AUTHOR) hfzahmed86@gmail.com |
| Source: | Nanomaterials (2079-4991). Jan2024, Vol. 14 Issue 1, p29. 15p. |
| Subjects: | Silver nanoparticles, Intravenous therapy, Leukocytes, Aspartate aminotransferase, Pharmacokinetics, Digestion |
| Abstract: | The widespread biomedical and commercial applications of silver nanoparticles (AgNPs) have increased their potential for human and environmental exposure and toxicity to human health. The bio-distribution and toxicity of AgNPs in rodents following inhalation, intratracheal instillation, and oral ingestion are well documented; however, little is known about the bio-distribution of intravenously (IV)-administered AgNPs and their organ-specific pathophysiological effects. Here, we investigate the pharmacokinetic pattern and tissue distribution of AgNPs in male rats following IV administration. The animals were humanely sacrificed after 10 min, 1 h, 6 h, 12 h, 24 h, and 168 h of AgNP administration, and the silver (Ag) content was measured from blood samples and various tissues following acid digestion. The AgNPs were readily absorbed and subsequently distributed into most organs predominantly in the colon, small intestine, kidney, and heart after 6 h; however, they were the highest in the spinal cord after 168 h. White blood cells (WBCs) were significantly increased (42–60%) in AgNP-administered animals at all time points except 10 min. Regarding platelets, all AgNP-administered animals showed counts 7.8–39.2% lower, with the lowest count at 168 h post-administration. In the case of lymphocytes (LYMs), the AgNP-treated animals exhibited a count 19.5–41% lower at 10 min and 1 h post-administration; however, the animals at 168 h post-administration showed a count 30.5% more. The mean corpuscular hemoglobin (MCH) counts from the AgNP-treated animals were decreased by 50–62%. The concentrations of aspartate transaminase (AST), urea, and creatinine were increased in the AgNP-treated animals. Taken together, the results suggest that the acute IV administration of AgNPs alters metabolic and hematological parameters in animals and may pose a health risk to humans. [ABSTRACT FROM AUTHOR] |
| Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
|
Full text is not displayed to guests.
Login for full access.
|
|
| FullText | Links: – Type: pdflink Text: Availability: 1 |
|---|---|
| Header | DbId: egs DbLabel: Engineering Source An: 174718758 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Tissue Distribution, Pharmacokinetics, and Effect of Hematological and Biochemical Parameters of Acute Intravenous Administration of Silver Nanoparticles in Rats. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Salim%2C+Elsayed+I%2E%22">Salim, Elsayed I.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> elsayed.salim@science.tanta.edu.eg</i><br /><searchLink fieldCode="AR" term="%22Abdel-Halim%2C+Khaled+Y%2E%22">Abdel-Halim, Khaled Y.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> khaled_yassen68@yahoo.com</i><br /><searchLink fieldCode="AR" term="%22El-Mahalawy%2C+Mostafa+E%2E%22">El-Mahalawy, Mostafa E.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> melmehlawy@yahoo.com</i><br /><searchLink fieldCode="AR" term="%22Badr%2C+Haitham+A%2E%22">Badr, Haitham A.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> egy.hab@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Ahmed%2C+Hafiz%22">Ahmed, Hafiz</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> hfzahmed86@gmail.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nanomaterials+%282079-4991%29%22">Nanomaterials (2079-4991)</searchLink>. Jan2024, Vol. 14 Issue 1, p29. 15p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Silver+nanoparticles%22">Silver nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Intravenous+therapy%22">Intravenous therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Leukocytes%22">Leukocytes</searchLink><br /><searchLink fieldCode="DE" term="%22Aspartate+aminotransferase%22">Aspartate aminotransferase</searchLink><br /><searchLink fieldCode="DE" term="%22Pharmacokinetics%22">Pharmacokinetics</searchLink><br /><searchLink fieldCode="DE" term="%22Digestion%22">Digestion</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The widespread biomedical and commercial applications of silver nanoparticles (AgNPs) have increased their potential for human and environmental exposure and toxicity to human health. The bio-distribution and toxicity of AgNPs in rodents following inhalation, intratracheal instillation, and oral ingestion are well documented; however, little is known about the bio-distribution of intravenously (IV)-administered AgNPs and their organ-specific pathophysiological effects. Here, we investigate the pharmacokinetic pattern and tissue distribution of AgNPs in male rats following IV administration. The animals were humanely sacrificed after 10 min, 1 h, 6 h, 12 h, 24 h, and 168 h of AgNP administration, and the silver (Ag) content was measured from blood samples and various tissues following acid digestion. The AgNPs were readily absorbed and subsequently distributed into most organs predominantly in the colon, small intestine, kidney, and heart after 6 h; however, they were the highest in the spinal cord after 168 h. White blood cells (WBCs) were significantly increased (42–60%) in AgNP-administered animals at all time points except 10 min. Regarding platelets, all AgNP-administered animals showed counts 7.8–39.2% lower, with the lowest count at 168 h post-administration. In the case of lymphocytes (LYMs), the AgNP-treated animals exhibited a count 19.5–41% lower at 10 min and 1 h post-administration; however, the animals at 168 h post-administration showed a count 30.5% more. The mean corpuscular hemoglobin (MCH) counts from the AgNP-treated animals were decreased by 50–62%. The concentrations of aspartate transaminase (AST), urea, and creatinine were increased in the AgNP-treated animals. Taken together, the results suggest that the acute IV administration of AgNPs alters metabolic and hematological parameters in animals and may pose a health risk to humans. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=174718758 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/nano14010029 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 15 StartPage: 29 Subjects: – SubjectFull: Silver nanoparticles Type: general – SubjectFull: Intravenous therapy Type: general – SubjectFull: Leukocytes Type: general – SubjectFull: Aspartate aminotransferase Type: general – SubjectFull: Pharmacokinetics Type: general – SubjectFull: Digestion Type: general Titles: – TitleFull: Tissue Distribution, Pharmacokinetics, and Effect of Hematological and Biochemical Parameters of Acute Intravenous Administration of Silver Nanoparticles in Rats. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Salim, Elsayed I. – PersonEntity: Name: NameFull: Abdel-Halim, Khaled Y. – PersonEntity: Name: NameFull: El-Mahalawy, Mostafa E. – PersonEntity: Name: NameFull: Badr, Haitham A. – PersonEntity: Name: NameFull: Ahmed, Hafiz IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 20794991 Numbering: – Type: volume Value: 14 – Type: issue Value: 1 Titles: – TitleFull: Nanomaterials (2079-4991) Type: main |
| ResultId | 1 |
