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Thermoplastic polyurethane surface coated with polymer brushes for reduced protein and cell attachment.

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Title: Thermoplastic polyurethane surface coated with polymer brushes for reduced protein and cell attachment.
Authors: Almousa, Rashed1,2 (AUTHOR), Xie, Dong1,3 (AUTHOR) dxie@iupui.edu, Chen, Yong3 (AUTHOR), Li, Jiliang4 (AUTHOR), Anderson, Gregory G.4 (AUTHOR)
Source: Journal of Biomaterials Applications. Jan2024, Vol. 38 Issue 6, p758-771. 14p.
Subjects: National Institutes of Health (U.S.), Polyurethanes, Contact angle, Bacterial adhesion, Addition polymerization, Acrylic acid
Abstract: The objective of this study was to coat negatively charged polymer brushes covalently onto the surface of thermoplastic polyurethane (TPU) using a simple conventional surface free-radical polymerization technique. The coated surfaces were assessed with contact angle, protein adsorption, cell adhesion and bacterial adhesion. Bovine serum albumin (BSA) and bovine fibrinogen (BFG) were used for protein adsorption evaluation. Mouse fibroblasts (NIH-3T3) and Pseudomonas aeruginosa (P. aeruginosa) were used to assess surface adhesion. Results show that the TPU surface modified with the attached polymer brushes exhibited significantly reduced contact angle, protein adsorption, and cell as well as bacterial adhesion, among which the negatively charged polymers showed the extremely low values in all the tests. Its contact angle is 5°, as compared to 70° for original TPU. Its BSA, BFG, 3T3 adhesion and P. aeruginosa adhesion were 93%, 84%, 92%, and 93% lower than original TPU. Furthermore, the TPU surface coated with negatively charged polymer brushes exhibited a hydrogel-like property. The results indicate that placing acrylic acids using a simple surface-initiated free-radical polymerization onto a TPU surface and then converting those to negative charges can be an effective and efficient route for fouling resistant applications. Graphical Abstract [ABSTRACT FROM AUTHOR]
Copyright of Journal of Biomaterials Applications is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 174788624
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Thermoplastic polyurethane surface coated with polymer brushes for reduced protein and cell attachment.
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  Data: <searchLink fieldCode="AR" term="%22Almousa%2C+Rashed%22">Almousa, Rashed</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xie%2C+Dong%22">Xie, Dong</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> dxie@iupui.edu</i><br /><searchLink fieldCode="AR" term="%22Chen%2C+Yong%22">Chen, Yong</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Jiliang%22">Li, Jiliang</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Anderson%2C+Gregory+G%2E%22">Anderson, Gregory G.</searchLink><relatesTo>4</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Biomaterials+Applications%22">Journal of Biomaterials Applications</searchLink>. Jan2024, Vol. 38 Issue 6, p758-771. 14p.
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  Data: <searchLink fieldCode="DE" term="%22National+Institutes+of+Health+%28U%2ES%2E%29%22">National Institutes of Health (U.S.)</searchLink><br /><searchLink fieldCode="DE" term="%22Polyurethanes%22">Polyurethanes</searchLink><br /><searchLink fieldCode="DE" term="%22Contact+angle%22">Contact angle</searchLink><br /><searchLink fieldCode="DE" term="%22Bacterial+adhesion%22">Bacterial adhesion</searchLink><br /><searchLink fieldCode="DE" term="%22Addition+polymerization%22">Addition polymerization</searchLink><br /><searchLink fieldCode="DE" term="%22Acrylic+acid%22">Acrylic acid</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The objective of this study was to coat negatively charged polymer brushes covalently onto the surface of thermoplastic polyurethane (TPU) using a simple conventional surface free-radical polymerization technique. The coated surfaces were assessed with contact angle, protein adsorption, cell adhesion and bacterial adhesion. Bovine serum albumin (BSA) and bovine fibrinogen (BFG) were used for protein adsorption evaluation. Mouse fibroblasts (NIH-3T3) and Pseudomonas aeruginosa (P. aeruginosa) were used to assess surface adhesion. Results show that the TPU surface modified with the attached polymer brushes exhibited significantly reduced contact angle, protein adsorption, and cell as well as bacterial adhesion, among which the negatively charged polymers showed the extremely low values in all the tests. Its contact angle is 5°, as compared to 70° for original TPU. Its BSA, BFG, 3T3 adhesion and P. aeruginosa adhesion were 93%, 84%, 92%, and 93% lower than original TPU. Furthermore, the TPU surface coated with negatively charged polymer brushes exhibited a hydrogel-like property. The results indicate that placing acrylic acids using a simple surface-initiated free-radical polymerization onto a TPU surface and then converting those to negative charges can be an effective and efficient route for fouling resistant applications. Graphical Abstract [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Biomaterials Applications is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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        Value: 10.1177/08853282231213937
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 14
        StartPage: 758
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      – SubjectFull: National Institutes of Health (U.S.)
        Type: general
      – SubjectFull: Polyurethanes
        Type: general
      – SubjectFull: Contact angle
        Type: general
      – SubjectFull: Bacterial adhesion
        Type: general
      – SubjectFull: Addition polymerization
        Type: general
      – SubjectFull: Acrylic acid
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      – TitleFull: Thermoplastic polyurethane surface coated with polymer brushes for reduced protein and cell attachment.
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            NameFull: Almousa, Rashed
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            NameFull: Xie, Dong
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            NameFull: Chen, Yong
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            – D: 01
              M: 01
              Text: Jan2024
              Type: published
              Y: 2024
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              Value: 38
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