The Effect of Sex on Ventricular Arrhythmic Events in Patients with Congestive Heart Failure.
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| Title: | The Effect of Sex on Ventricular Arrhythmic Events in Patients with Congestive Heart Failure. |
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| Authors: | Aronson, Doron1, Burger, Andrew J.2 aburger@caregroup.harvard.edu |
| Source: | Pacing & Clinical Electrophysiology. Aug2002, Vol. 25 Issue 8, p1206-1211. 6p. |
| Subjects: | Heart failure, Heart diseases, Therapeutics, Drug therapy, Arrhythmia, Cardiology |
| Abstract: | The propensity to develop specific arrhythmias varies between the sexes. Patients with congestive heart failure (CHF) have a high prevalence of ventricular ectopy. However, it is not known if sex related differences exist in the susceptibility to arrhythmias in the setting of CHF. The study population included 159 men and 77 women (mean age 61 ± 14 years) admitted for decompensated CHF. The severity of atrial and ventricular arrhythmias was assessed by 24-hour Holter monitoring. None of the patients were on parenteral vasoactive therapy during Holter recording. All measures of ventricular ectopy were markedly lower in women compared to men. The mean hourly ventricular pairs (283 ± 67 vs 106 ± 30, P = 0.04), mean hourly repetitive ventricular beats (28 ± 7 vs 10 ± 3, P = 0.04), and the frequency of ventricular tachycardia episodes per 24 hours (31 ± 9 vs 7 ± 3, P = 0.01) were significantly lower in women. After inclusion of clinical variables and drug therapies in a multivariate analysis, the negative relationship between female sex and the frequency of ventricular pairs (P = 0.04), repetitive ventricular beats (P = 0.04), and ventricular tachycardia episodes (P = 0.0005) remained independent. No differences in atrial ectopy between men and woman were found. Complex ventricular ectopy and episodes of ventricular tachycardia are significantly lower in women with CHF. Whether these finding are relevant to female survival advantage in the setting of heart failure can only be determined by a prospective study. Further understanding of the mechanisms involved in the protection conferred by the patient's sex would advance our understanding about arrhythmias in heart failure. [ABSTRACT FROM AUTHOR] |
| Copyright of Pacing & Clinical Electrophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 17507143 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The Effect of Sex on Ventricular Arrhythmic Events in Patients with Congestive Heart Failure. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Aronson%2C+Doron%22">Aronson, Doron</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Burger%2C+Andrew+J%2E%22">Burger, Andrew J.</searchLink><relatesTo>2</relatesTo><i> aburger@caregroup.harvard.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Pacing+%26+Clinical+Electrophysiology%22">Pacing & Clinical Electrophysiology</searchLink>. Aug2002, Vol. 25 Issue 8, p1206-1211. 6p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Heart+failure%22">Heart failure</searchLink><br /><searchLink fieldCode="DE" term="%22Heart+diseases%22">Heart diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+therapy%22">Drug therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Arrhythmia%22">Arrhythmia</searchLink><br /><searchLink fieldCode="DE" term="%22Cardiology%22">Cardiology</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The propensity to develop specific arrhythmias varies between the sexes. Patients with congestive heart failure (CHF) have a high prevalence of ventricular ectopy. However, it is not known if sex related differences exist in the susceptibility to arrhythmias in the setting of CHF. The study population included 159 men and 77 women (mean age 61 ± 14 years) admitted for decompensated CHF. The severity of atrial and ventricular arrhythmias was assessed by 24-hour Holter monitoring. None of the patients were on parenteral vasoactive therapy during Holter recording. All measures of ventricular ectopy were markedly lower in women compared to men. The mean hourly ventricular pairs (283 ± 67 vs 106 ± 30, P = 0.04), mean hourly repetitive ventricular beats (28 ± 7 vs 10 ± 3, P = 0.04), and the frequency of ventricular tachycardia episodes per 24 hours (31 ± 9 vs 7 ± 3, P = 0.01) were significantly lower in women. After inclusion of clinical variables and drug therapies in a multivariate analysis, the negative relationship between female sex and the frequency of ventricular pairs (P = 0.04), repetitive ventricular beats (P = 0.04), and ventricular tachycardia episodes (P = 0.0005) remained independent. No differences in atrial ectopy between men and woman were found. Complex ventricular ectopy and episodes of ventricular tachycardia are significantly lower in women with CHF. Whether these finding are relevant to female survival advantage in the setting of heart failure can only be determined by a prospective study. Further understanding of the mechanisms involved in the protection conferred by the patient's sex would advance our understanding about arrhythmias in heart failure. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Pacing & Clinical Electrophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1046/j.1460-9592.2002.01206.x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 1206 Subjects: – SubjectFull: Heart failure Type: general – SubjectFull: Heart diseases Type: general – SubjectFull: Therapeutics Type: general – SubjectFull: Drug therapy Type: general – SubjectFull: Arrhythmia Type: general – SubjectFull: Cardiology Type: general Titles: – TitleFull: The Effect of Sex on Ventricular Arrhythmic Events in Patients with Congestive Heart Failure. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Aronson, Doron – PersonEntity: Name: NameFull: Burger, Andrew J. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2002 Type: published Y: 2002 Identifiers: – Type: issn-print Value: 01478389 Numbering: – Type: volume Value: 25 – Type: issue Value: 8 Titles: – TitleFull: Pacing & Clinical Electrophysiology Type: main |
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