A mathematical model for velocity‐selective arterial spin labeling.
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| Title: | A mathematical model for velocity‐selective arterial spin labeling. |
|---|---|
| Authors: | Liu, Thomas T.1,2,3 (AUTHOR) ttliu@ucsd.edu, Wong, Eric C.1,2,3 (AUTHOR), Bolar, Divya S.1,2 (AUTHOR), Chen, Conan1,2,4 (AUTHOR), Barnes, Ryan S.1,2,4 (AUTHOR) |
| Source: | Magnetic Resonance in Medicine. Apr2024, Vol. 91 Issue 4, p1384-1403. 20p. |
| Subjects: | Spin labels, Mathematical models, Cardiovascular system, Velocity, Experimental design |
| Abstract: | Purpose: To present a theoretical framework that rigorously defines and analyzes key concepts and quantities for velocity selective arterial spin labeling (VSASL). Theory and Methods: An expression for the VSASL arterial delivery function is derived based on (1) labeling and saturation profiles as a function of velocity and (2) physiologically plausible approximations of changes in acceleration and velocity across the vascular system. The dependence of labeling efficiency on the amplitude and effective bolus width of the arterial delivery function is defined. Factors that affect the effective bolus width are examined, and timing requirements to minimize quantitation errors are derived. Results: The model predicts that a flow‐dependent negative bias in the effective bolus width can occur when velocity selective inversion (VSI) is used for the labeling module and velocity selective saturation (VSS) is used for the vascular crushing module. The bias can be minimized by choosing a nominal labeling cutoff velocity that is lower than the nominal cutoff velocity of the vascular crushing module. Conclusion: The elements of the model are specified in a general fashion such that future advances can be readily integrated. The model can facilitate further efforts to understand and characterize the performance of VSASL and provide critical theoretical insights that can be used to design future experiments and develop novel VSASL approaches. [ABSTRACT FROM AUTHOR] |
| Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 175196975 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A mathematical model for velocity‐selective arterial spin labeling. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Liu%2C+Thomas+T%2E%22">Liu, Thomas T.</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<i> ttliu@ucsd.edu</i><br /><searchLink fieldCode="AR" term="%22Wong%2C+Eric+C%2E%22">Wong, Eric C.</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bolar%2C+Divya+S%2E%22">Bolar, Divya S.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Conan%22">Chen, Conan</searchLink><relatesTo>1,2,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Barnes%2C+Ryan+S%2E%22">Barnes, Ryan S.</searchLink><relatesTo>1,2,4</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Apr2024, Vol. 91 Issue 4, p1384-1403. 20p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Spin+labels%22">Spin labels</searchLink><br /><searchLink fieldCode="DE" term="%22Mathematical+models%22">Mathematical models</searchLink><br /><searchLink fieldCode="DE" term="%22Cardiovascular+system%22">Cardiovascular system</searchLink><br /><searchLink fieldCode="DE" term="%22Velocity%22">Velocity</searchLink><br /><searchLink fieldCode="DE" term="%22Experimental+design%22">Experimental design</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: To present a theoretical framework that rigorously defines and analyzes key concepts and quantities for velocity selective arterial spin labeling (VSASL). Theory and Methods: An expression for the VSASL arterial delivery function is derived based on (1) labeling and saturation profiles as a function of velocity and (2) physiologically plausible approximations of changes in acceleration and velocity across the vascular system. The dependence of labeling efficiency on the amplitude and effective bolus width of the arterial delivery function is defined. Factors that affect the effective bolus width are examined, and timing requirements to minimize quantitation errors are derived. Results: The model predicts that a flow‐dependent negative bias in the effective bolus width can occur when velocity selective inversion (VSI) is used for the labeling module and velocity selective saturation (VSS) is used for the vascular crushing module. The bias can be minimized by choosing a nominal labeling cutoff velocity that is lower than the nominal cutoff velocity of the vascular crushing module. Conclusion: The elements of the model are specified in a general fashion such that future advances can be readily integrated. The model can facilitate further efforts to understand and characterize the performance of VSASL and provide critical theoretical insights that can be used to design future experiments and develop novel VSASL approaches. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=175196975 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mrm.29935 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 20 StartPage: 1384 Subjects: – SubjectFull: Spin labels Type: general – SubjectFull: Mathematical models Type: general – SubjectFull: Cardiovascular system Type: general – SubjectFull: Velocity Type: general – SubjectFull: Experimental design Type: general Titles: – TitleFull: A mathematical model for velocity‐selective arterial spin labeling. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Liu, Thomas T. – PersonEntity: Name: NameFull: Wong, Eric C. – PersonEntity: Name: NameFull: Bolar, Divya S. – PersonEntity: Name: NameFull: Chen, Conan – PersonEntity: Name: NameFull: Barnes, Ryan S. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 07403194 Numbering: – Type: volume Value: 91 – Type: issue Value: 4 Titles: – TitleFull: Magnetic Resonance in Medicine Type: main |
| ResultId | 1 |
