High‐resolution three‐dimensional dosimetry in clinically relevant volumes utilizing optically stimulated luminescence.
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| Title: | High‐resolution three‐dimensional dosimetry in clinically relevant volumes utilizing optically stimulated luminescence. |
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| Authors: | Jensen, Mads L.1 (AUTHOR) mlj@phys.au.dk, Julsgaard, Brian1,2 (AUTHOR), Turtos, Rosana M.1 (AUTHOR), Skyt, Peter S.3 (AUTHOR), Jensen, Morten B.3,4 (AUTHOR), Muren, Ludvig P.3,5 (AUTHOR), Balling, Peter1,2 (AUTHOR) |
| Source: | Medical Physics. Mar2024, Vol. 51 Issue 3, p2200-2209. 10p. |
| Subjects: | Medical dosimetry, Optically stimulated luminescence, Photon beams, Thermoluminescence dosimetry, Monte Carlo method, Radiation doses, Proton beams, Statistical errors |
| Abstract: | Background: The continued development of new radiotherapy techniques requires dosimetry systems that satisfy increasingly rigorous requirements, such as high sensitivity, wide dose range, and high spatial resolution. An emerging requirement is the ability to read out doses in three dimensions (3D) with high precision and spatial resolution. A few dosimetry systems with 3D capabilities are available, but their application in a clinical workflow is limited for various reasons, primarily originating from their chemical nature. The search for a 3D dosimetry system with potential for clinical implementation is thus ongoing. Purpose: To demonstrate the capabilities of a novel optically‐stimulated‐luminescence (OSL)‐based 3D dosimetry system capable of measuring radiation doses in clinically relevant volumes. Methods: A laser‐based readout system was used to measure dose distributions delivered by both photons and protons, utilizing the OSL from a 50×50×50$50\times 50\times 50$ mm 3$^3$ YSO:Ce crystal. A homogeneous treatment plan consisting of two opposing photon fields was used to establish an inhomogeneity correction map of the crystal response and demonstrated the accuracy and precision of the system. The crystal was additionally irradiated with a photon treatment plan consisting of three overlapping 10×10$10\times 10$ mm 2$^2$ fields delivered from different angles, and a proton treatment plan consisting of four pencil beams with energies 90 MeV (×2$\times 2$), 115 MeV, and 140 MeV. The system abilities were quantified by comparing the 3D‐resolved measurements to Monte Carlo simulations. Results: The dose map reproducibility of the system was found to be within 2% including both statistical and systematic errors. The measurements yielded integrated doses from a volume of 50×50×40$50\times 50\times 40$ mm 3$^3$ with voxel volumes of just 0.28×0.28×0.50$0.28\times 0.28\times 0.50$ mm 3$^3$. An excellent agreement between the 3D‐resolved measurements and the simulations was found for both photon‐ and proton‐irradiation. Conclusions: The capabilities of the devised system for measuring clinically relevant fields of photons and proton pencil beams within a clinically relevant volume were demonstrated. The system poses as a promising candidate for clinical applications, and enables future research in the field of OSL‐based tissue‐equivalent 3D dosimetry. [ABSTRACT FROM AUTHOR] |
| Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: egs DbLabel: Engineering Source An: 175989206 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: High‐resolution three‐dimensional dosimetry in clinically relevant volumes utilizing optically stimulated luminescence. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Jensen%2C+Mads+L%2E%22">Jensen, Mads L.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> mlj@phys.au.dk</i><br /><searchLink fieldCode="AR" term="%22Julsgaard%2C+Brian%22">Julsgaard, Brian</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Turtos%2C+Rosana+M%2E%22">Turtos, Rosana M.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Skyt%2C+Peter+S%2E%22">Skyt, Peter S.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jensen%2C+Morten+B%2E%22">Jensen, Morten B.</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Muren%2C+Ludvig+P%2E%22">Muren, Ludvig P.</searchLink><relatesTo>3,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Balling%2C+Peter%22">Balling, Peter</searchLink><relatesTo>1,2</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Medical+Physics%22">Medical Physics</searchLink>. Mar2024, Vol. 51 Issue 3, p2200-2209. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Medical+dosimetry%22">Medical dosimetry</searchLink><br /><searchLink fieldCode="DE" term="%22Optically+stimulated+luminescence%22">Optically stimulated luminescence</searchLink><br /><searchLink fieldCode="DE" term="%22Photon+beams%22">Photon beams</searchLink><br /><searchLink fieldCode="DE" term="%22Thermoluminescence+dosimetry%22">Thermoluminescence dosimetry</searchLink><br /><searchLink fieldCode="DE" term="%22Monte+Carlo+method%22">Monte Carlo method</searchLink><br /><searchLink fieldCode="DE" term="%22Radiation+doses%22">Radiation doses</searchLink><br /><searchLink fieldCode="DE" term="%22Proton+beams%22">Proton beams</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+errors%22">Statistical errors</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: The continued development of new radiotherapy techniques requires dosimetry systems that satisfy increasingly rigorous requirements, such as high sensitivity, wide dose range, and high spatial resolution. An emerging requirement is the ability to read out doses in three dimensions (3D) with high precision and spatial resolution. A few dosimetry systems with 3D capabilities are available, but their application in a clinical workflow is limited for various reasons, primarily originating from their chemical nature. The search for a 3D dosimetry system with potential for clinical implementation is thus ongoing. Purpose: To demonstrate the capabilities of a novel optically‐stimulated‐luminescence (OSL)‐based 3D dosimetry system capable of measuring radiation doses in clinically relevant volumes. Methods: A laser‐based readout system was used to measure dose distributions delivered by both photons and protons, utilizing the OSL from a 50×50×50$50\times 50\times 50$ mm 3$^3$ YSO:Ce crystal. A homogeneous treatment plan consisting of two opposing photon fields was used to establish an inhomogeneity correction map of the crystal response and demonstrated the accuracy and precision of the system. The crystal was additionally irradiated with a photon treatment plan consisting of three overlapping 10×10$10\times 10$ mm 2$^2$ fields delivered from different angles, and a proton treatment plan consisting of four pencil beams with energies 90 MeV (×2$\times 2$), 115 MeV, and 140 MeV. The system abilities were quantified by comparing the 3D‐resolved measurements to Monte Carlo simulations. Results: The dose map reproducibility of the system was found to be within 2% including both statistical and systematic errors. The measurements yielded integrated doses from a volume of 50×50×40$50\times 50\times 40$ mm 3$^3$ with voxel volumes of just 0.28×0.28×0.50$0.28\times 0.28\times 0.50$ mm 3$^3$. An excellent agreement between the 3D‐resolved measurements and the simulations was found for both photon‐ and proton‐irradiation. Conclusions: The capabilities of the devised system for measuring clinically relevant fields of photons and proton pencil beams within a clinically relevant volume were demonstrated. The system poses as a promising candidate for clinical applications, and enables future research in the field of OSL‐based tissue‐equivalent 3D dosimetry. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mp.16796 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 2200 Subjects: – SubjectFull: Medical dosimetry Type: general – SubjectFull: Optically stimulated luminescence Type: general – SubjectFull: Photon beams Type: general – SubjectFull: Thermoluminescence dosimetry Type: general – SubjectFull: Monte Carlo method Type: general – SubjectFull: Radiation doses Type: general – SubjectFull: Proton beams Type: general – SubjectFull: Statistical errors Type: general Titles: – TitleFull: High‐resolution three‐dimensional dosimetry in clinically relevant volumes utilizing optically stimulated luminescence. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Jensen, Mads L. – PersonEntity: Name: NameFull: Julsgaard, Brian – PersonEntity: Name: NameFull: Turtos, Rosana M. – PersonEntity: Name: NameFull: Skyt, Peter S. – PersonEntity: Name: NameFull: Jensen, Morten B. – PersonEntity: Name: NameFull: Muren, Ludvig P. – PersonEntity: Name: NameFull: Balling, Peter IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 00942405 Numbering: – Type: volume Value: 51 – Type: issue Value: 3 Titles: – TitleFull: Medical Physics Type: main |
| ResultId | 1 |
