Technical Note: Impact of impurities on Yttrium‐90 glass microsphere activity quantitation.
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| Title: | Technical Note: Impact of impurities on Yttrium‐90 glass microsphere activity quantitation. |
|---|---|
| Authors: | Beattie, Bradley J.1 (AUTHOR), Kirov, Assen S.1 (AUTHOR), Kesner, Adam L.1 (AUTHOR) kesnera@mskcc.org |
| Source: | Medical Physics. Mar2024, Vol. 51 Issue 3, p2306-2310. 5p. |
| Subjects: | Radioactivity measurements, Ionization chambers, Technical specifications, Absorbed dose, Glass |
| Abstract: | Background: Glass 90Y microspheres are produced with known radionuclide impurities. These impurities are not independently monitored. Clinical instruments, including ionization chamber dose calibrators and positron emmission tomography (PET) cameras, can be much more sensitive in detecting signals from these impurities than to signals from 90Y itself. Purpose: The "typical" levels of 90Y impurities have been studied to assess their impact on dosimetry during internal implantation, and for the management of waste. However, unaccounted‐for decay spectra of impurities can also have an impact on dose calibrator and PET readings. Thus, even what might be considered negligibly small impurity fractions, can in principle cause substantial overestimates of the amount of 90Y activity present in a sample. To our knowledge, quantitative effects of radionuclide impurities in glass microspheres on activity measurements have not been documented in the field. As activity quantitation for dosimetry and its correlations with outcome becomes more prevalent, the effects of impurities on measurements may remain unaccounted for in dosimetry studies. Methods: In this letter, we review theoretical and physical considerations that will result in asymmetric errors in quantitation from 90Y impurities and estimate their typical and potential impact on clinical utilization. Among the common impurities 88Y is of particular concern for its impact on 90Y dose measurements because of its decay characteristics, along with other isotopes 91Y and 46Sc which can also impact measurements. Results: The typical level of 88Y impurities reported by the manufacturer should only cause small errors in dose calibrator and PET measurements made within the 12‐day label‐specified use‐by period, up to 2.0% and 1.6%, respectively. However, the product specification max allowable impurity levels, specified by the manufacturer, leave open the potential for much greater bias from within the 12‐day use‐by period, potentially as high as 13.2% for dose calibrator measurements and 10.6% for PET from the 88Y impurities. Conclusions: While typical levels of impurities appear to have acceptable impact on patient absorbed dose, it should be noted that they can have adverse effects on 90Y radioactivity measurements. Furthermore, there is currently minimal independent verification and/or monitoring of impurity levels within the field. [ABSTRACT FROM AUTHOR] |
| Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Items | – Name: Title Label: Title Group: Ti Data: Technical Note: Impact of impurities on Yttrium‐90 glass microsphere activity quantitation. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Beattie%2C+Bradley+J%2E%22">Beattie, Bradley J.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kirov%2C+Assen+S%2E%22">Kirov, Assen S.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kesner%2C+Adam+L%2E%22">Kesner, Adam L.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> kesnera@mskcc.org</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Medical+Physics%22">Medical Physics</searchLink>. Mar2024, Vol. 51 Issue 3, p2306-2310. 5p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Radioactivity+measurements%22">Radioactivity measurements</searchLink><br /><searchLink fieldCode="DE" term="%22Ionization+chambers%22">Ionization chambers</searchLink><br /><searchLink fieldCode="DE" term="%22Technical+specifications%22">Technical specifications</searchLink><br /><searchLink fieldCode="DE" term="%22Absorbed+dose%22">Absorbed dose</searchLink><br /><searchLink fieldCode="DE" term="%22Glass%22">Glass</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: Glass 90Y microspheres are produced with known radionuclide impurities. These impurities are not independently monitored. Clinical instruments, including ionization chamber dose calibrators and positron emmission tomography (PET) cameras, can be much more sensitive in detecting signals from these impurities than to signals from 90Y itself. Purpose: The "typical" levels of 90Y impurities have been studied to assess their impact on dosimetry during internal implantation, and for the management of waste. However, unaccounted‐for decay spectra of impurities can also have an impact on dose calibrator and PET readings. Thus, even what might be considered negligibly small impurity fractions, can in principle cause substantial overestimates of the amount of 90Y activity present in a sample. To our knowledge, quantitative effects of radionuclide impurities in glass microspheres on activity measurements have not been documented in the field. As activity quantitation for dosimetry and its correlations with outcome becomes more prevalent, the effects of impurities on measurements may remain unaccounted for in dosimetry studies. Methods: In this letter, we review theoretical and physical considerations that will result in asymmetric errors in quantitation from 90Y impurities and estimate their typical and potential impact on clinical utilization. Among the common impurities 88Y is of particular concern for its impact on 90Y dose measurements because of its decay characteristics, along with other isotopes 91Y and 46Sc which can also impact measurements. Results: The typical level of 88Y impurities reported by the manufacturer should only cause small errors in dose calibrator and PET measurements made within the 12‐day label‐specified use‐by period, up to 2.0% and 1.6%, respectively. However, the product specification max allowable impurity levels, specified by the manufacturer, leave open the potential for much greater bias from within the 12‐day use‐by period, potentially as high as 13.2% for dose calibrator measurements and 10.6% for PET from the 88Y impurities. Conclusions: While typical levels of impurities appear to have acceptable impact on patient absorbed dose, it should be noted that they can have adverse effects on 90Y radioactivity measurements. Furthermore, there is currently minimal independent verification and/or monitoring of impurity levels within the field. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mp.16828 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 2306 Subjects: – SubjectFull: Radioactivity measurements Type: general – SubjectFull: Ionization chambers Type: general – SubjectFull: Technical specifications Type: general – SubjectFull: Absorbed dose Type: general – SubjectFull: Glass Type: general Titles: – TitleFull: Technical Note: Impact of impurities on Yttrium‐90 glass microsphere activity quantitation. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Beattie, Bradley J. – PersonEntity: Name: NameFull: Kirov, Assen S. – PersonEntity: Name: NameFull: Kesner, Adam L. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 00942405 Numbering: – Type: volume Value: 51 – Type: issue Value: 3 Titles: – TitleFull: Medical Physics Type: main |
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