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Quantification of whole‐organ individual and bilateral renal metabolic rate of oxygen.

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Title: Quantification of whole‐organ individual and bilateral renal metabolic rate of oxygen.
Authors: Deshpande, Rajiv S.1 (AUTHOR), Langham, Michael C.1 (AUTHOR), Lee, Hyunyeol1,2 (AUTHOR), Kamona, Nada1 (AUTHOR), Wehrli, Felix W.1 (AUTHOR) felix.wehrli@pennmedicine.upenn.edu
Source: Magnetic Resonance in Medicine. May2024, Vol. 91 Issue 5, p2057-2073. 17p.
Subjects: Vena cava inferior, Oxygen saturation, Renal veins, Kidney physiology, Blood flow
Abstract: Purpose: Renal metabolic rate of oxygen (rMRO2) is a potentially important biomarker of kidney function. The key parameters for rMRO2 quantification include blood flow rate (BFR) and venous oxygen saturation (SvO2) in a draining vessel. Previous approaches to quantify renal metabolism have focused on the single organ. Here, both kidneys are considered as one unit to quantify bilateral rMRO2. A pulse sequence to facilitate bilateral rMRO2 quantification is introduced. Methods: To quantify bilateral rMRO2, measurements of BFR and SvO2 are made along the inferior vena cava (IVC) at suprarenal and infrarenal locations. From the continuity equation, these four parameters can be related to derive an expression for bilateral rMRO2. The recently reported K‐MOTIVE pulse sequence was implemented at four locations: left kidney, right kidney, suprarenal IVC, and infrarenal IVC. A dual‐band variant of K‐MOTIVE (db‐K‐MOTIVE) was developed by incorporating simultaneous‐multi‐slice imaging principles. The sequence simultaneously measures BFR and SvO2 at suprarenal and infrarenal locations in a single pass of 21 s, yielding bilateral rMRO2. Results: SvO2 and BFR are higher in suprarenal versus infrarenal IVC, and the renal veins are highly oxygenated (SvO2 >90%). Bilateral rMRO2 quantified in 10 healthy subjects (8 M, 30 ± 8 y) was found to be 291 ± 247 and 349 ± 300 (μmolO2/min)/100 g, derived from K‐MOTIVE and db‐K‐MOTIVE, respectively. In comparison, total rMRO2 from combining left and right was 329 ± 273 (μmolO2/min)/100 g. Conclusion: The present work demonstrates that bilateral rMRO2 quantification is feasible with fair reproducibility and physiological plausibility. The indirect method is a promising approach to compute bilateral rMRO2 when individual rMRO2 quantification is difficult. [ABSTRACT FROM AUTHOR]
Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
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  Data: Quantification of whole‐organ individual and bilateral renal metabolic rate of oxygen.
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  Data: <searchLink fieldCode="AR" term="%22Deshpande%2C+Rajiv+S%2E%22">Deshpande, Rajiv S.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Langham%2C+Michael+C%2E%22">Langham, Michael C.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Hyunyeol%22">Lee, Hyunyeol</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kamona%2C+Nada%22">Kamona, Nada</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wehrli%2C+Felix+W%2E%22">Wehrli, Felix W.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> felix.wehrli@pennmedicine.upenn.edu</i>
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  Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. May2024, Vol. 91 Issue 5, p2057-2073. 17p.
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  Data: <searchLink fieldCode="DE" term="%22Vena+cava+inferior%22">Vena cava inferior</searchLink><br /><searchLink fieldCode="DE" term="%22Oxygen+saturation%22">Oxygen saturation</searchLink><br /><searchLink fieldCode="DE" term="%22Renal+veins%22">Renal veins</searchLink><br /><searchLink fieldCode="DE" term="%22Kidney+physiology%22">Kidney physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+flow%22">Blood flow</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: Renal metabolic rate of oxygen (rMRO2) is a potentially important biomarker of kidney function. The key parameters for rMRO2 quantification include blood flow rate (BFR) and venous oxygen saturation (SvO2) in a draining vessel. Previous approaches to quantify renal metabolism have focused on the single organ. Here, both kidneys are considered as one unit to quantify bilateral rMRO2. A pulse sequence to facilitate bilateral rMRO2 quantification is introduced. Methods: To quantify bilateral rMRO2, measurements of BFR and SvO2 are made along the inferior vena cava (IVC) at suprarenal and infrarenal locations. From the continuity equation, these four parameters can be related to derive an expression for bilateral rMRO2. The recently reported K‐MOTIVE pulse sequence was implemented at four locations: left kidney, right kidney, suprarenal IVC, and infrarenal IVC. A dual‐band variant of K‐MOTIVE (db‐K‐MOTIVE) was developed by incorporating simultaneous‐multi‐slice imaging principles. The sequence simultaneously measures BFR and SvO2 at suprarenal and infrarenal locations in a single pass of 21 s, yielding bilateral rMRO2. Results: SvO2 and BFR are higher in suprarenal versus infrarenal IVC, and the renal veins are highly oxygenated (SvO2 >90%). Bilateral rMRO2 quantified in 10 healthy subjects (8 M, 30 ± 8 y) was found to be 291 ± 247 and 349 ± 300 (μmolO2/min)/100 g, derived from K‐MOTIVE and db‐K‐MOTIVE, respectively. In comparison, total rMRO2 from combining left and right was 329 ± 273 (μmolO2/min)/100 g. Conclusion: The present work demonstrates that bilateral rMRO2 quantification is feasible with fair reproducibility and physiological plausibility. The indirect method is a promising approach to compute bilateral rMRO2 when individual rMRO2 quantification is difficult. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/mrm.29981
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        Text: English
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      – SubjectFull: Vena cava inferior
        Type: general
      – SubjectFull: Oxygen saturation
        Type: general
      – SubjectFull: Renal veins
        Type: general
      – SubjectFull: Kidney physiology
        Type: general
      – SubjectFull: Blood flow
        Type: general
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      – TitleFull: Quantification of whole‐organ individual and bilateral renal metabolic rate of oxygen.
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              M: 05
              Text: May2024
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              Y: 2024
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