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Using isopropanol as the hydrogen donor to achieve by-product-free biological hydrogenation in water with carbonyl reductase.

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Title: Using isopropanol as the hydrogen donor to achieve by-product-free biological hydrogenation in water with carbonyl reductase.
Authors: Bu, Chongyang1 (AUTHOR), Tao, Yuanming1 (AUTHOR), Fu, Jiaming1 (AUTHOR), Tan, Huanghong1 (AUTHOR), Zheng, Zhaojuan1 (AUTHOR), Ouyang, Jia1 (AUTHOR) hgouyj@njfu.edu.cn
Source: International Journal of Hydrogen Energy. Apr2024, Vol. 62, p969-978. 10p.
Subjects: Carbonyl reductase, Furfural, NAD (Coenzyme), Furfuryl alcohol, Hydrogenation, Isopropyl alcohol
Abstract: In this study, the reaction equilibrium was broken using isopropanol as a co-substrate, which was different from previous glucose as a co-substrate for furfural reduction, solving the problems of many by-products, low selectivity, and the addition of sodium phosphate buffers. The volatility of isopropanol and acetone prevented the production of by-products to the reaction system, improving the conversion and selectivity. 10 g/L furfural could be converted into furfuryl alcohol in pure water, and the furfural conversion was 90%, furfuryl alcohol selectivity was 100%, and the concentration of furfuryl alcohol could reach more than 20 g/L through accumulation reaction. No by-products were produced in this reaction system, and a single furfuryl alcohol product was obtained in the water catalytic system, which was convenient for downstream separation and purification. At the same time, based on the theory of the NADH coenzyme cycle system, this catalytic method could complete the conversion of various aldehydes into the corresponding alcohols, and it could be expanded to various biological hydrogenation projects, which has important industrial development and production prospects. [Display omitted] • Realized the biological hydrogenation of furfural in water. • The volatility of isopropanol and acetone disrupts the reaction equilibrium. • There are no by-products remaining in the system after the reaction. • Substrate spectrum can be expanded to enable biohydrogenation engineering. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Hydrogen Energy is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 176391688
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Using isopropanol as the hydrogen donor to achieve by-product-free biological hydrogenation in water with carbonyl reductase.
– Name: Author
  Label: Authors
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  Data: <searchLink fieldCode="AR" term="%22Bu%2C+Chongyang%22">Bu, Chongyang</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tao%2C+Yuanming%22">Tao, Yuanming</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fu%2C+Jiaming%22">Fu, Jiaming</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tan%2C+Huanghong%22">Tan, Huanghong</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zheng%2C+Zhaojuan%22">Zheng, Zhaojuan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ouyang%2C+Jia%22">Ouyang, Jia</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> hgouyj@njfu.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Hydrogen+Energy%22">International Journal of Hydrogen Energy</searchLink>. Apr2024, Vol. 62, p969-978. 10p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Carbonyl+reductase%22">Carbonyl reductase</searchLink><br /><searchLink fieldCode="DE" term="%22Furfural%22">Furfural</searchLink><br /><searchLink fieldCode="DE" term="%22NAD+%28Coenzyme%29%22">NAD (Coenzyme)</searchLink><br /><searchLink fieldCode="DE" term="%22Furfuryl+alcohol%22">Furfuryl alcohol</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrogenation%22">Hydrogenation</searchLink><br /><searchLink fieldCode="DE" term="%22Isopropyl+alcohol%22">Isopropyl alcohol</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: In this study, the reaction equilibrium was broken using isopropanol as a co-substrate, which was different from previous glucose as a co-substrate for furfural reduction, solving the problems of many by-products, low selectivity, and the addition of sodium phosphate buffers. The volatility of isopropanol and acetone prevented the production of by-products to the reaction system, improving the conversion and selectivity. 10 g/L furfural could be converted into furfuryl alcohol in pure water, and the furfural conversion was 90%, furfuryl alcohol selectivity was 100%, and the concentration of furfuryl alcohol could reach more than 20 g/L through accumulation reaction. No by-products were produced in this reaction system, and a single furfuryl alcohol product was obtained in the water catalytic system, which was convenient for downstream separation and purification. At the same time, based on the theory of the NADH coenzyme cycle system, this catalytic method could complete the conversion of various aldehydes into the corresponding alcohols, and it could be expanded to various biological hydrogenation projects, which has important industrial development and production prospects. [Display omitted] • Realized the biological hydrogenation of furfural in water. • The volatility of isopropanol and acetone disrupts the reaction equilibrium. • There are no by-products remaining in the system after the reaction. • Substrate spectrum can be expanded to enable biohydrogenation engineering. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Hydrogen Energy is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.ijhydene.2024.03.167
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 10
        StartPage: 969
    Subjects:
      – SubjectFull: Carbonyl reductase
        Type: general
      – SubjectFull: Furfural
        Type: general
      – SubjectFull: NAD (Coenzyme)
        Type: general
      – SubjectFull: Furfuryl alcohol
        Type: general
      – SubjectFull: Hydrogenation
        Type: general
      – SubjectFull: Isopropyl alcohol
        Type: general
    Titles:
      – TitleFull: Using isopropanol as the hydrogen donor to achieve by-product-free biological hydrogenation in water with carbonyl reductase.
        Type: main
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          Name:
            NameFull: Bu, Chongyang
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            NameFull: Tao, Yuanming
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            NameFull: Fu, Jiaming
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            NameFull: Tan, Huanghong
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            NameFull: Zheng, Zhaojuan
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            NameFull: Ouyang, Jia
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            – D: 10
              M: 04
              Text: Apr2024
              Type: published
              Y: 2024
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              Value: 03603199
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              Value: 62
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            – TitleFull: International Journal of Hydrogen Energy
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