Optimization of assessment of the function of the main protective mechanisms of the respiratory systme based on the use of albumin aerosol.
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| Title: | Optimization of assessment of the function of the main protective mechanisms of the respiratory systme based on the use of albumin aerosol. |
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| Authors: | Kobylyansky, V. I.1 (AUTHOR) kobylyansky@mail.ru |
| Source: | Measurement Techniques. Jan2024, Vol. 66 Issue 10, p813-818. 6p. |
| Subjects: | Aerodynamic measurements, Functional assessment, Mucociliary system, Aerosols, Respiratory organs, Albumins |
| Abstract: | The article describes the most informative, direct and non-invasive radioaerosol method for studying the main protective mechanisms of the respiratory system, the processes of inhaled substances deposition and clearing them from the lungs due to the mucociliary system function (mucociliary clearance). The method involves inhalation of a diagnostic radioisotope-labelled drug and subsequent analysis of the dynamics of distribution and excretion of this drug. Based on the analysis results, the above-mentioned processes of inhaled substances deposition and clearing them from the lungs are judged. The accuracy of assessing these processes depends on the aerodynamic properties of the inhalant, for which albumin dispersion systems were chosen as the most physiological material. In order to optimize the measurement of parameters of the aerodynamic properties of a diagnostic aerosol, a comparative analysis of different measurement methods and different albumin dispersion systems was performed. It has been established that the most informative and economically feasible method for assessing the aerodynamic properties of an inhalant is the scanning electron microscopy method. This method was used to assess the dispersion systems, i.e. albumin macroaggregates produced by foreign manufacturers and albumin microspheres manufactured using domestic technology. It has been shown that domestic albumin microspheres have optimal aerodynamic parameters for studying the processes of inhaled substances deposition and mucociliary clearance of the lungs. However, to definitively assess the potential use of these albumin microspheres, direct assessment of their deposition in the lungs is necessary. [ABSTRACT FROM AUTHOR] |
| Copyright of Measurement Techniques is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 176688463 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Optimization of assessment of the function of the main protective mechanisms of the respiratory systme based on the use of albumin aerosol. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kobylyansky%2C+V%2E+I%2E%22">Kobylyansky, V. I.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> kobylyansky@mail.ru</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Measurement+Techniques%22">Measurement Techniques</searchLink>. Jan2024, Vol. 66 Issue 10, p813-818. 6p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Aerodynamic+measurements%22">Aerodynamic measurements</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+assessment%22">Functional assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Mucociliary+system%22">Mucociliary system</searchLink><br /><searchLink fieldCode="DE" term="%22Aerosols%22">Aerosols</searchLink><br /><searchLink fieldCode="DE" term="%22Respiratory+organs%22">Respiratory organs</searchLink><br /><searchLink fieldCode="DE" term="%22Albumins%22">Albumins</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The article describes the most informative, direct and non-invasive radioaerosol method for studying the main protective mechanisms of the respiratory system, the processes of inhaled substances deposition and clearing them from the lungs due to the mucociliary system function (mucociliary clearance). The method involves inhalation of a diagnostic radioisotope-labelled drug and subsequent analysis of the dynamics of distribution and excretion of this drug. Based on the analysis results, the above-mentioned processes of inhaled substances deposition and clearing them from the lungs are judged. The accuracy of assessing these processes depends on the aerodynamic properties of the inhalant, for which albumin dispersion systems were chosen as the most physiological material. In order to optimize the measurement of parameters of the aerodynamic properties of a diagnostic aerosol, a comparative analysis of different measurement methods and different albumin dispersion systems was performed. It has been established that the most informative and economically feasible method for assessing the aerodynamic properties of an inhalant is the scanning electron microscopy method. This method was used to assess the dispersion systems, i.e. albumin macroaggregates produced by foreign manufacturers and albumin microspheres manufactured using domestic technology. It has been shown that domestic albumin microspheres have optimal aerodynamic parameters for studying the processes of inhaled substances deposition and mucociliary clearance of the lungs. However, to definitively assess the potential use of these albumin microspheres, direct assessment of their deposition in the lungs is necessary. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Measurement Techniques is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=176688463 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s11018-024-02295-0 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 813 Subjects: – SubjectFull: Aerodynamic measurements Type: general – SubjectFull: Functional assessment Type: general – SubjectFull: Mucociliary system Type: general – SubjectFull: Aerosols Type: general – SubjectFull: Respiratory organs Type: general – SubjectFull: Albumins Type: general Titles: – TitleFull: Optimization of assessment of the function of the main protective mechanisms of the respiratory systme based on the use of albumin aerosol. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kobylyansky, V. I. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 05431972 Numbering: – Type: volume Value: 66 – Type: issue Value: 10 Titles: – TitleFull: Measurement Techniques Type: main |
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