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Physiochemical Characterization of Lipidic Nanoformulations Encapsulating the Antifungal Drug Natamycin.

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Title: Physiochemical Characterization of Lipidic Nanoformulations Encapsulating the Antifungal Drug Natamycin.
Authors: Talarico, Luigi1,2,3 (AUTHOR) luigi.talarico@student.unisi.it, Clemente, Ilaria1,3 (AUTHOR) ilaria.clemente2@unisi.it, Gennari, Alessandro1 (AUTHOR) alessandro.gennari@student.unisi.it, Gabbricci, Giulia1,3 (AUTHOR) giulia.gabbricci@student.unisi.it, Pepi, Simone1,2,3 (AUTHOR) pepi11@student.unisi.it, Leone, Gemma1,2,3 (AUTHOR) gemma.leone@unisi.it, Bonechi, Claudia1,3 (AUTHOR) claudia.bonechi@unisi.it, Rossi, Claudio1,3 (AUTHOR) claudio.rossi@unisi.it, Mattioli, Simone Luca4 (AUTHOR) simone.mattioli@dompe.com, Detta, Nicola4 (AUTHOR) nicola.detta@dompe.com, Magnani, Agnese1,2,3 (AUTHOR) agnese.magnani@unisi.it
Source: Nanomaterials (2079-4991). Apr2024, Vol. 14 Issue 8, p726. 13p.
Subjects: Fungal cell walls, Antifungal agents, X-ray scattering, Topical drug administration, Zeta potential, Light scattering
Abstract: Natamycin is a tetraene polyene that exploits its antifungal properties by irreversibly binding components of fungal cell walls, blocking the growth of infections. However, topical ocular treatments with natamycin require frequent application due to the low ability of this molecule to permeate the ocular membrane. This limitation has limited the use of natamycin as an antimycotic drug, despite it being one of the most powerful known antimycotic agents. In this work, different lipidic nanoformulations consisting of transethosomes or lipid nanoparticles containing natamycin are proposed as carriers for optical topical administration. Size, stability and zeta potential were characterized via dynamic light scattering, the supramolecular structure was investigated via small- and wide-angle X-ray scattering and 1H-NMR, and the encapsulation efficiencies of the four proposed formulations were determined via HPLC-DAD. [ABSTRACT FROM AUTHOR]
Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Physiochemical Characterization of Lipidic Nanoformulations Encapsulating the Antifungal Drug Natamycin.
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  Data: <searchLink fieldCode="AR" term="%22Talarico%2C+Luigi%22">Talarico, Luigi</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<i> luigi.talarico@student.unisi.it</i><br /><searchLink fieldCode="AR" term="%22Clemente%2C+Ilaria%22">Clemente, Ilaria</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> ilaria.clemente2@unisi.it</i><br /><searchLink fieldCode="AR" term="%22Gennari%2C+Alessandro%22">Gennari, Alessandro</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> alessandro.gennari@student.unisi.it</i><br /><searchLink fieldCode="AR" term="%22Gabbricci%2C+Giulia%22">Gabbricci, Giulia</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> giulia.gabbricci@student.unisi.it</i><br /><searchLink fieldCode="AR" term="%22Pepi%2C+Simone%22">Pepi, Simone</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<i> pepi11@student.unisi.it</i><br /><searchLink fieldCode="AR" term="%22Leone%2C+Gemma%22">Leone, Gemma</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<i> gemma.leone@unisi.it</i><br /><searchLink fieldCode="AR" term="%22Bonechi%2C+Claudia%22">Bonechi, Claudia</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> claudia.bonechi@unisi.it</i><br /><searchLink fieldCode="AR" term="%22Rossi%2C+Claudio%22">Rossi, Claudio</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> claudio.rossi@unisi.it</i><br /><searchLink fieldCode="AR" term="%22Mattioli%2C+Simone+Luca%22">Mattioli, Simone Luca</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> simone.mattioli@dompe.com</i><br /><searchLink fieldCode="AR" term="%22Detta%2C+Nicola%22">Detta, Nicola</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> nicola.detta@dompe.com</i><br /><searchLink fieldCode="AR" term="%22Magnani%2C+Agnese%22">Magnani, Agnese</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<i> agnese.magnani@unisi.it</i>
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  Data: <searchLink fieldCode="JN" term="%22Nanomaterials+%282079-4991%29%22">Nanomaterials (2079-4991)</searchLink>. Apr2024, Vol. 14 Issue 8, p726. 13p.
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  Data: <searchLink fieldCode="DE" term="%22Fungal+cell+walls%22">Fungal cell walls</searchLink><br /><searchLink fieldCode="DE" term="%22Antifungal+agents%22">Antifungal agents</searchLink><br /><searchLink fieldCode="DE" term="%22X-ray+scattering%22">X-ray scattering</searchLink><br /><searchLink fieldCode="DE" term="%22Topical+drug+administration%22">Topical drug administration</searchLink><br /><searchLink fieldCode="DE" term="%22Zeta+potential%22">Zeta potential</searchLink><br /><searchLink fieldCode="DE" term="%22Light+scattering%22">Light scattering</searchLink>
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  Label: Abstract
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  Data: Natamycin is a tetraene polyene that exploits its antifungal properties by irreversibly binding components of fungal cell walls, blocking the growth of infections. However, topical ocular treatments with natamycin require frequent application due to the low ability of this molecule to permeate the ocular membrane. This limitation has limited the use of natamycin as an antimycotic drug, despite it being one of the most powerful known antimycotic agents. In this work, different lipidic nanoformulations consisting of transethosomes or lipid nanoparticles containing natamycin are proposed as carriers for optical topical administration. Size, stability and zeta potential were characterized via dynamic light scattering, the supramolecular structure was investigated via small- and wide-angle X-ray scattering and 1H-NMR, and the encapsulation efficiencies of the four proposed formulations were determined via HPLC-DAD. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3390/nano14080726
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      – Code: eng
        Text: English
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        PageCount: 13
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      – SubjectFull: Fungal cell walls
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      – SubjectFull: Antifungal agents
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      – SubjectFull: X-ray scattering
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      – TitleFull: Physiochemical Characterization of Lipidic Nanoformulations Encapsulating the Antifungal Drug Natamycin.
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