A Computational Investigation of the Effects of Temporal Synchronization of Left Ventricular Assist Device Speed Modulation with the Cardiac Cycle on Intraventricular Hemodynamics.
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| Title: | A Computational Investigation of the Effects of Temporal Synchronization of Left Ventricular Assist Device Speed Modulation with the Cardiac Cycle on Intraventricular Hemodynamics. |
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| Authors: | Straccia, Angela1 (AUTHOR) straccia@uw.edu, Chassagne, Fanette2 (AUTHOR), Barbour, Michael C.1 (AUTHOR), Beckman, Jennifer3 (AUTHOR), Li, Song4 (AUTHOR), Mahr, Claudius4 (AUTHOR), Aliseda, Alberto1 (AUTHOR) |
| Source: | Annals of Biomedical Engineering. Jun2024, Vol. 52 Issue 6, p1763-1778. 16p. |
| Subjects: | Heart beat, Heart assist devices, Computational fluid dynamics, Stagnation point, Pulsatile flow, Particle image velocimetry, Hemodynamics |
| Abstract: | Patients with advanced heart failure are implanted with a left ventricular assist device (LVAD) as a bridge-to-transplantation or destination therapy. Despite advances in pump design, the risk of stroke remains high. LVAD implantation significantly alters intraventricular hemodynamics, where regions of stagnation or elevated shear stresses promote thrombus formation. Third generation pumps incorporate a pulsatility mode that modulates rotational speed of the pump to enhance in-pump washout. We investigated how the timing of the pulsatility mode with the cardiac cycle affects intraventricular hemodynamic factors linked to thrombus formation. Computational fluid dynamics simulations with Lagrangian particle tracking to model platelet behavior in a patient-specific left ventricle captured altered intraventricular hemodynamics due to LVAD implantation. HeartMate 3 incorporates a pulsatility mode that modulates the speed of the pump every two seconds. Four different timings of this pulsatility mode with respect to the cardiac cycle were investigated. A strong jet formed between the mitral valve and inflow cannula. Blood stagnated in the left ventricular outflow tract beneath a closed aortic valve, in the near-wall regions off-axis of the jet, and in a large counterrotating vortex near the anterior wall. Computational results showed good agreement with particle image velocimetry results. Synchronization of the pulsatility mode with peak systole decreased stasis, reflected in the intraventricular washout of virtual contrast and Lagrangian particles over time. Temporal synchronization of HeartMate 3 pulsatility with the cardiac cycle reduces intraventricular stasis and could be beneficial for decreasing thrombogenicity. [ABSTRACT FROM AUTHOR] |
| Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: egs DbLabel: Engineering Source An: 177148682 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A Computational Investigation of the Effects of Temporal Synchronization of Left Ventricular Assist Device Speed Modulation with the Cardiac Cycle on Intraventricular Hemodynamics. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Straccia%2C+Angela%22">Straccia, Angela</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> straccia@uw.edu</i><br /><searchLink fieldCode="AR" term="%22Chassagne%2C+Fanette%22">Chassagne, Fanette</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Barbour%2C+Michael+C%2E%22">Barbour, Michael C.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Beckman%2C+Jennifer%22">Beckman, Jennifer</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Song%22">Li, Song</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mahr%2C+Claudius%22">Mahr, Claudius</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Aliseda%2C+Alberto%22">Aliseda, Alberto</searchLink><relatesTo>1</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Annals+of+Biomedical+Engineering%22">Annals of Biomedical Engineering</searchLink>. Jun2024, Vol. 52 Issue 6, p1763-1778. 16p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Heart+beat%22">Heart beat</searchLink><br /><searchLink fieldCode="DE" term="%22Heart+assist+devices%22">Heart assist devices</searchLink><br /><searchLink fieldCode="DE" term="%22Computational+fluid+dynamics%22">Computational fluid dynamics</searchLink><br /><searchLink fieldCode="DE" term="%22Stagnation+point%22">Stagnation point</searchLink><br /><searchLink fieldCode="DE" term="%22Pulsatile+flow%22">Pulsatile flow</searchLink><br /><searchLink fieldCode="DE" term="%22Particle+image+velocimetry%22">Particle image velocimetry</searchLink><br /><searchLink fieldCode="DE" term="%22Hemodynamics%22">Hemodynamics</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Patients with advanced heart failure are implanted with a left ventricular assist device (LVAD) as a bridge-to-transplantation or destination therapy. Despite advances in pump design, the risk of stroke remains high. LVAD implantation significantly alters intraventricular hemodynamics, where regions of stagnation or elevated shear stresses promote thrombus formation. Third generation pumps incorporate a pulsatility mode that modulates rotational speed of the pump to enhance in-pump washout. We investigated how the timing of the pulsatility mode with the cardiac cycle affects intraventricular hemodynamic factors linked to thrombus formation. Computational fluid dynamics simulations with Lagrangian particle tracking to model platelet behavior in a patient-specific left ventricle captured altered intraventricular hemodynamics due to LVAD implantation. HeartMate 3 incorporates a pulsatility mode that modulates the speed of the pump every two seconds. Four different timings of this pulsatility mode with respect to the cardiac cycle were investigated. A strong jet formed between the mitral valve and inflow cannula. Blood stagnated in the left ventricular outflow tract beneath a closed aortic valve, in the near-wall regions off-axis of the jet, and in a large counterrotating vortex near the anterior wall. Computational results showed good agreement with particle image velocimetry results. Synchronization of the pulsatility mode with peak systole decreased stasis, reflected in the intraventricular washout of virtual contrast and Lagrangian particles over time. Temporal synchronization of HeartMate 3 pulsatility with the cardiac cycle reduces intraventricular stasis and could be beneficial for decreasing thrombogenicity. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10439-024-03489-x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 16 StartPage: 1763 Subjects: – SubjectFull: Heart beat Type: general – SubjectFull: Heart assist devices Type: general – SubjectFull: Computational fluid dynamics Type: general – SubjectFull: Stagnation point Type: general – SubjectFull: Pulsatile flow Type: general – SubjectFull: Particle image velocimetry Type: general – SubjectFull: Hemodynamics Type: general Titles: – TitleFull: A Computational Investigation of the Effects of Temporal Synchronization of Left Ventricular Assist Device Speed Modulation with the Cardiac Cycle on Intraventricular Hemodynamics. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Straccia, Angela – PersonEntity: Name: NameFull: Chassagne, Fanette – PersonEntity: Name: NameFull: Barbour, Michael C. – PersonEntity: Name: NameFull: Beckman, Jennifer – PersonEntity: Name: NameFull: Li, Song – PersonEntity: Name: NameFull: Mahr, Claudius – PersonEntity: Name: NameFull: Aliseda, Alberto IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 00906964 Numbering: – Type: volume Value: 52 – Type: issue Value: 6 Titles: – TitleFull: Annals of Biomedical Engineering Type: main |
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