Ultra-sensitive SERS detection of L-tyrosine on the microstructurally tuned DC sputtered plasmonic Bi thin films.
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| Title: | Ultra-sensitive SERS detection of L-tyrosine on the microstructurally tuned DC sputtered plasmonic Bi thin films. |
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| Authors: | Philip, Risa Marium1 (AUTHOR), Bharathi Mohan, D.1 (AUTHOR) d.bharathimohan@gmail.com |
| Source: | Applied Physics A: Materials Science & Processing. May2024, Vol. 130 Issue 5, p1-27. 27p. |
| Subjects: | Thin films, DC sputtering, SERS spectroscopy, Surface plasmon resonance, Tyrosine, Magnetron sputtering, Thyroid hormone receptors |
| Abstract: | This work aims on developing plasmonic bismuth (Bi) thin films for ultra-sensitive detection of L-tyrosine (Tyr) using label-free Surface Enhanced Raman Spectroscopy (SERS) technique. Tyr is a crucial precursor in the formation of several neurotransmitters, melanin, and thyroid hormones. Sensing the qualitative and quantitative imbalances in Tyr opens up the possibility of diagnosing a variety of autoimmune, neurodegenerative, and physiological illnesses. Bi thin films were fabricated through DC magnetron sputtering employing both in-situ deposition and ex-situ vacuum annealing processes. Varied annealing temperatures of 100 °C and 200 °C were used in each case. Among all, the ex-situ films at 200 °C exhibited enhanced microstructural, morphological, and optical characteristics. This film showed an optimum surface morphology aiding in intense Localized Surface Plasmon Resonance (LSPR) absorption. The HRSTEM results observed are supported by Raman modes and GI-XRD pattern. A preferential orientation change is observed in the tailored Bi film. Multiple SPRs arising from interband transitions and XPS etching studies confirm the metallic nature of Bi films. FESEM with EDS demonstrates film homogeneity and compositional purity. All the Bi films were tested for a preliminary SERS limit of detection (LoD) study using Rhodamine 6G (RH6G), for selecting a better substrate, supported by the hydrophobicity and Raman mapping studies done. The optimized SERS platform exhibited an unprecedented sensitivity, reaching upto 1 pM level LoD for Tyr with an ultra-sensitive SERS Enhancement Factor (EF) of 1.69 × 1012. The detection of Tyr suggests the potential of Bi thin films as a promising alternative for ultra-sensitive SERS biosensing platforms. [ABSTRACT FROM AUTHOR] |
| Copyright of Applied Physics A: Materials Science & Processing is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Items | – Name: Title Label: Title Group: Ti Data: Ultra-sensitive SERS detection of L-tyrosine on the microstructurally tuned DC sputtered plasmonic Bi thin films. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Philip%2C+Risa+Marium%22">Philip, Risa Marium</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bharathi+Mohan%2C+D%2E%22">Bharathi Mohan, D.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> d.bharathimohan@gmail.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Applied+Physics+A%3A+Materials+Science+%26+Processing%22">Applied Physics A: Materials Science & Processing</searchLink>. May2024, Vol. 130 Issue 5, p1-27. 27p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Thin+films%22">Thin films</searchLink><br /><searchLink fieldCode="DE" term="%22DC+sputtering%22">DC sputtering</searchLink><br /><searchLink fieldCode="DE" term="%22SERS+spectroscopy%22">SERS spectroscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Surface+plasmon+resonance%22">Surface plasmon resonance</searchLink><br /><searchLink fieldCode="DE" term="%22Tyrosine%22">Tyrosine</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetron+sputtering%22">Magnetron sputtering</searchLink><br /><searchLink fieldCode="DE" term="%22Thyroid+hormone+receptors%22">Thyroid hormone receptors</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: This work aims on developing plasmonic bismuth (Bi) thin films for ultra-sensitive detection of L-tyrosine (Tyr) using label-free Surface Enhanced Raman Spectroscopy (SERS) technique. Tyr is a crucial precursor in the formation of several neurotransmitters, melanin, and thyroid hormones. Sensing the qualitative and quantitative imbalances in Tyr opens up the possibility of diagnosing a variety of autoimmune, neurodegenerative, and physiological illnesses. Bi thin films were fabricated through DC magnetron sputtering employing both in-situ deposition and ex-situ vacuum annealing processes. Varied annealing temperatures of 100 °C and 200 °C were used in each case. Among all, the ex-situ films at 200 °C exhibited enhanced microstructural, morphological, and optical characteristics. This film showed an optimum surface morphology aiding in intense Localized Surface Plasmon Resonance (LSPR) absorption. The HRSTEM results observed are supported by Raman modes and GI-XRD pattern. A preferential orientation change is observed in the tailored Bi film. Multiple SPRs arising from interband transitions and XPS etching studies confirm the metallic nature of Bi films. FESEM with EDS demonstrates film homogeneity and compositional purity. All the Bi films were tested for a preliminary SERS limit of detection (LoD) study using Rhodamine 6G (RH6G), for selecting a better substrate, supported by the hydrophobicity and Raman mapping studies done. The optimized SERS platform exhibited an unprecedented sensitivity, reaching upto 1 pM level LoD for Tyr with an ultra-sensitive SERS Enhancement Factor (EF) of 1.69 × 1012. The detection of Tyr suggests the potential of Bi thin films as a promising alternative for ultra-sensitive SERS biosensing platforms. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Applied Physics A: Materials Science & Processing is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00339-024-07450-6 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 27 StartPage: 1 Subjects: – SubjectFull: Thin films Type: general – SubjectFull: DC sputtering Type: general – SubjectFull: SERS spectroscopy Type: general – SubjectFull: Surface plasmon resonance Type: general – SubjectFull: Tyrosine Type: general – SubjectFull: Magnetron sputtering Type: general – SubjectFull: Thyroid hormone receptors Type: general Titles: – TitleFull: Ultra-sensitive SERS detection of L-tyrosine on the microstructurally tuned DC sputtered plasmonic Bi thin films. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Philip, Risa Marium – PersonEntity: Name: NameFull: Bharathi Mohan, D. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: May2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 09478396 Numbering: – Type: volume Value: 130 – Type: issue Value: 5 Titles: – TitleFull: Applied Physics A: Materials Science & Processing Type: main |
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