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Wearable dual-drug controlled release patch for psoriasis treatment.

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Title: Wearable dual-drug controlled release patch for psoriasis treatment.
Authors: Zhao, Jiaxin1 (AUTHOR), Gong, Shengen1 (AUTHOR), Mu, Yueming2 (AUTHOR), Jia, Xiaoteng1,3 (AUTHOR) xtjia@jlu.edu.cn, Zhou, Yan1,3 (AUTHOR) yanzhou20@mails.jlu.edu.cn, Tian, Yaping1,2 (AUTHOR) typ@jlu.edu.cn, Chao, Danming1 (AUTHOR) chaodanming@jlu.edu.cn
Source: Journal of Colloid & Interface Science. Sep2024, Vol. 669, p835-843. 9p.
Subjects: Drug delivery systems, Tannins, Drug monitoring, Drug laws, Drug dosage, Psoriasis, Polyamides
Abstract: [Display omitted] • Hydrogel containing viologen-based hyperbranched polyamide amines with dual drug loading capacity. • Wearable Patch (Patch-DT) uses hydrogel as the drug-carrying cathode and magnesium flakes as the anode. • Patch-DT enables release of two drugs simultaneously, overcoming the limitations of monotherapy. • Visible drug monitoring through wearable Patch's electrochromic properties. Wearable drug delivery systems (DDS) have made significant advancements in the field of precision medicine, offering precise regulation of drug dosage, location, and timing. The performance qualities that wearable DDS has always strived for are simplicity, efficiency, and intelligence. This paper proposes a wearable dual-drug synergistic release patch. The patch is powered by a built-in magnesium battery and utilizes a hydrogel containing viologen-based hyperbranched polyamidoamine as both a cathode material and an integrated drug reservoir. This design allows for the simultaneous release of both dexamethasone and tannic acid, overcoming the limitations of monotherapy and ensuring effective synergy for on-demand therapy. In a mouse model with praziquimod-induced psoriasis, the patch demonstrated therapeutic efficacy at a low voltage. The inflammatory skin returned to normal after 5 days with the on-demand release of dual drugs. This work provides a promising treatment option considering its straightforward construction and the therapeutic advantages of dual-drug synergy. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Colloid & Interface Science is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 177420591
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Wearable dual-drug controlled release patch for psoriasis treatment.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Zhao%2C+Jiaxin%22">Zhao, Jiaxin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gong%2C+Shengen%22">Gong, Shengen</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mu%2C+Yueming%22">Mu, Yueming</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jia%2C+Xiaoteng%22">Jia, Xiaoteng</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> xtjia@jlu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Zhou%2C+Yan%22">Zhou, Yan</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> yanzhou20@mails.jlu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Tian%2C+Yaping%22">Tian, Yaping</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> typ@jlu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Chao%2C+Danming%22">Chao, Danming</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> chaodanming@jlu.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Colloid+%26+Interface+Science%22">Journal of Colloid & Interface Science</searchLink>. Sep2024, Vol. 669, p835-843. 9p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Drug+delivery+systems%22">Drug delivery systems</searchLink><br /><searchLink fieldCode="DE" term="%22Tannins%22">Tannins</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+monitoring%22">Drug monitoring</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+laws%22">Drug laws</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+dosage%22">Drug dosage</searchLink><br /><searchLink fieldCode="DE" term="%22Psoriasis%22">Psoriasis</searchLink><br /><searchLink fieldCode="DE" term="%22Polyamides%22">Polyamides</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: [Display omitted] • Hydrogel containing viologen-based hyperbranched polyamide amines with dual drug loading capacity. • Wearable Patch (Patch-DT) uses hydrogel as the drug-carrying cathode and magnesium flakes as the anode. • Patch-DT enables release of two drugs simultaneously, overcoming the limitations of monotherapy. • Visible drug monitoring through wearable Patch's electrochromic properties. Wearable drug delivery systems (DDS) have made significant advancements in the field of precision medicine, offering precise regulation of drug dosage, location, and timing. The performance qualities that wearable DDS has always strived for are simplicity, efficiency, and intelligence. This paper proposes a wearable dual-drug synergistic release patch. The patch is powered by a built-in magnesium battery and utilizes a hydrogel containing viologen-based hyperbranched polyamidoamine as both a cathode material and an integrated drug reservoir. This design allows for the simultaneous release of both dexamethasone and tannic acid, overcoming the limitations of monotherapy and ensuring effective synergy for on-demand therapy. In a mouse model with praziquimod-induced psoriasis, the patch demonstrated therapeutic efficacy at a low voltage. The inflammatory skin returned to normal after 5 days with the on-demand release of dual drugs. This work provides a promising treatment option considering its straightforward construction and the therapeutic advantages of dual-drug synergy. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Colloid & Interface Science is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.jcis.2024.05.064
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 835
    Subjects:
      – SubjectFull: Drug delivery systems
        Type: general
      – SubjectFull: Tannins
        Type: general
      – SubjectFull: Drug monitoring
        Type: general
      – SubjectFull: Drug laws
        Type: general
      – SubjectFull: Drug dosage
        Type: general
      – SubjectFull: Psoriasis
        Type: general
      – SubjectFull: Polyamides
        Type: general
    Titles:
      – TitleFull: Wearable dual-drug controlled release patch for psoriasis treatment.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Zhao, Jiaxin
      – PersonEntity:
          Name:
            NameFull: Gong, Shengen
      – PersonEntity:
          Name:
            NameFull: Mu, Yueming
      – PersonEntity:
          Name:
            NameFull: Jia, Xiaoteng
      – PersonEntity:
          Name:
            NameFull: Zhou, Yan
      – PersonEntity:
          Name:
            NameFull: Tian, Yaping
      – PersonEntity:
          Name:
            NameFull: Chao, Danming
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          Dates:
            – D: 01
              M: 09
              Text: Sep2024
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-print
              Value: 00219797
          Numbering:
            – Type: volume
              Value: 669
          Titles:
            – TitleFull: Journal of Colloid & Interface Science
              Type: main
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