Creating uniform cluster dose spread‐out Bragg peaks for proton and carbon beams.
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| Title: | Creating uniform cluster dose spread‐out Bragg peaks for proton and carbon beams. |
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| Authors: | Ortiz, Ramon1 (AUTHOR) ramon.ortizcatalan@ucsf.edu, Faddegon, Bruce1 (AUTHOR) |
| Source: | Medical Physics. Jun2024, Vol. 51 Issue 6, p4482-4488. 7p. |
| Subjects: | Proton beams, Radiotherapy treatment planning, Lead, Ion beams, Cell survival, Proton therapy |
| Abstract: | Background: Preliminary data have shown a close association of the generalized ionization cluster size dose (in short, cluster dose) with cell survival, independent of particle type, and energy, when cluster dose is derived from an ionization detail parameter preferred for its association with cell survival. Such results suggest cluster dose has the potential to replace RBE‐weighted dose in proton and ion beam radiotherapy treatment plan optimization, should a uniform cluster dose lead to comparable biological effects. However, further preclinical investigations are warranted to confirm this premise. Purpose: To present an analytical approach to create uniform cluster dose spread‐out Bragg peaks (SOBP) for evaluation of the potential of cluster dose to result in uniform biological effect. Methods: We modified the coefficients of the Bortfeld and Schlegel weight formula, an analytical method typically used for the creation of radiation dose SOBP in particle therapy, to produce uniform cluster dose SOBP of different widths (1–5 cm) at relevant clinical proton and carbon beam energies. Optimum parameters were found by minimization of the ratio between the maximum and minimum cluster dose in the SOBP region using the Nelder–Mead method. Results: The coefficients of the Bortfeld and Schlegel weight formula leading to uniform cluster dose SOBPs were determined for each combination of beam energy and SOBP width studied. The uniformity of the resulting cluster dose SOBPs, calculated as the relative difference between the maximum and minimum cluster dose within the SOBP, was within 0.3%–3.5% for the evaluated proton beams and 1.3%–3.4% for the evaluated carbon beams. Conclusions: The modifications to the analytical approach to create radiation dose SOBPs resulted in uniform cluster dose proton and carbon SOBPs over a wide range of beam energies and SOBP widths. Such SOBPs should prove valuable in preclinical investigations for the selection of nanodosimetric quantities to be used in proton and ion therapy treatment planning. [ABSTRACT FROM AUTHOR] |
| Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: egs DbLabel: Engineering Source An: 177626345 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Creating uniform cluster dose spread‐out Bragg peaks for proton and carbon beams. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ortiz%2C+Ramon%22">Ortiz, Ramon</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> ramon.ortizcatalan@ucsf.edu</i><br /><searchLink fieldCode="AR" term="%22Faddegon%2C+Bruce%22">Faddegon, Bruce</searchLink><relatesTo>1</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Medical+Physics%22">Medical Physics</searchLink>. Jun2024, Vol. 51 Issue 6, p4482-4488. 7p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Proton+beams%22">Proton beams</searchLink><br /><searchLink fieldCode="DE" term="%22Radiotherapy+treatment+planning%22">Radiotherapy treatment planning</searchLink><br /><searchLink fieldCode="DE" term="%22Lead%22">Lead</searchLink><br /><searchLink fieldCode="DE" term="%22Ion+beams%22">Ion beams</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+survival%22">Cell survival</searchLink><br /><searchLink fieldCode="DE" term="%22Proton+therapy%22">Proton therapy</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: Preliminary data have shown a close association of the generalized ionization cluster size dose (in short, cluster dose) with cell survival, independent of particle type, and energy, when cluster dose is derived from an ionization detail parameter preferred for its association with cell survival. Such results suggest cluster dose has the potential to replace RBE‐weighted dose in proton and ion beam radiotherapy treatment plan optimization, should a uniform cluster dose lead to comparable biological effects. However, further preclinical investigations are warranted to confirm this premise. Purpose: To present an analytical approach to create uniform cluster dose spread‐out Bragg peaks (SOBP) for evaluation of the potential of cluster dose to result in uniform biological effect. Methods: We modified the coefficients of the Bortfeld and Schlegel weight formula, an analytical method typically used for the creation of radiation dose SOBP in particle therapy, to produce uniform cluster dose SOBP of different widths (1–5 cm) at relevant clinical proton and carbon beam energies. Optimum parameters were found by minimization of the ratio between the maximum and minimum cluster dose in the SOBP region using the Nelder–Mead method. Results: The coefficients of the Bortfeld and Schlegel weight formula leading to uniform cluster dose SOBPs were determined for each combination of beam energy and SOBP width studied. The uniformity of the resulting cluster dose SOBPs, calculated as the relative difference between the maximum and minimum cluster dose within the SOBP, was within 0.3%–3.5% for the evaluated proton beams and 1.3%–3.4% for the evaluated carbon beams. Conclusions: The modifications to the analytical approach to create radiation dose SOBPs resulted in uniform cluster dose proton and carbon SOBPs over a wide range of beam energies and SOBP widths. Such SOBPs should prove valuable in preclinical investigations for the selection of nanodosimetric quantities to be used in proton and ion therapy treatment planning. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mp.16991 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 4482 Subjects: – SubjectFull: Proton beams Type: general – SubjectFull: Radiotherapy treatment planning Type: general – SubjectFull: Lead Type: general – SubjectFull: Ion beams Type: general – SubjectFull: Cell survival Type: general – SubjectFull: Proton therapy Type: general Titles: – TitleFull: Creating uniform cluster dose spread‐out Bragg peaks for proton and carbon beams. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ortiz, Ramon – PersonEntity: Name: NameFull: Faddegon, Bruce IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 00942405 Numbering: – Type: volume Value: 51 – Type: issue Value: 6 Titles: – TitleFull: Medical Physics Type: main |
| ResultId | 1 |
