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Iridium oxide-based non-enzymatic glucose sensor: Superior electro-catalytic performance in biological environmental media.

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Title: Iridium oxide-based non-enzymatic glucose sensor: Superior electro-catalytic performance in biological environmental media.
Authors: Jeon, Ji Hwan1 (AUTHOR), Lim, Hyo-Ryoung2 (AUTHOR), Park, Ji Young1 (AUTHOR) jiyoung3073@hanyang.ac.kr, Choa, Yong-Ho1 (AUTHOR) choa15@hanyang.ac.kr
Source: Environmental Research. Jul2024:Part 2, Vol. 252, pN.PAG-N.PAG. 1p.
Subjects: Glucose analysis, Continuous glucose monitoring, Iridium, Glucose, Iridium oxide, Detectors, Extracellular fluid
Abstract: Nanostructured inorganic materials have potential advantages as glucose-sensing elements in diabetes care, thereby circumventing the need for expensive enzymatic agents. However, many nonenzymatic sensors face challenges related to selectivity and reliability, reducing their efficacy in body fluids. In this study, we introduce an Iridium oxide (IrO 2)-based non-enzymatic glucose sensor. This sensor demonstrates exceptional electro-catalytic properties in human serum, characterized by high sensitivity (638 μA μM−1cm2) and a consistent recovery rate (∼104%) across 15 cycles in saline. Furthermore, its impressive performance in human serum, as evidenced by a low relative standard deviation (RSD <1.57%), underscores its applicability in biological matrices such as interstitial fluids. Overall, the IrO 2 sensor is a promising, highly reversible, economical, and simple method for detecting glucose in continuous monitoring systems. [Display omitted] • Economical IrO 2 non-enzymatic glucose sensor with high sensitivity. • Optimized IrO 2 coating on Au layer ensures stability and robust adhesion. • Superior selectivity in presence of interferents in uric acid and ascorbic acid. • Demonstrated consistent recovery (∼104%) at IrO 2 of 300 cycles in human serum. • Biosensor offers broad linear range and notable stability in human serum. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
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Abstract:Nanostructured inorganic materials have potential advantages as glucose-sensing elements in diabetes care, thereby circumventing the need for expensive enzymatic agents. However, many nonenzymatic sensors face challenges related to selectivity and reliability, reducing their efficacy in body fluids. In this study, we introduce an Iridium oxide (IrO 2)-based non-enzymatic glucose sensor. This sensor demonstrates exceptional electro-catalytic properties in human serum, characterized by high sensitivity (638 μA μM−1cm2) and a consistent recovery rate (∼104%) across 15 cycles in saline. Furthermore, its impressive performance in human serum, as evidenced by a low relative standard deviation (RSD <1.57%), underscores its applicability in biological matrices such as interstitial fluids. Overall, the IrO 2 sensor is a promising, highly reversible, economical, and simple method for detecting glucose in continuous monitoring systems. [Display omitted] • Economical IrO 2 non-enzymatic glucose sensor with high sensitivity. • Optimized IrO 2 coating on Au layer ensures stability and robust adhesion. • Superior selectivity in presence of interferents in uric acid and ascorbic acid. • Demonstrated consistent recovery (∼104%) at IrO 2 of 300 cycles in human serum. • Biosensor offers broad linear range and notable stability in human serum. [ABSTRACT FROM AUTHOR]
ISSN:00139351
DOI:10.1016/j.envres.2024.118772