View in EDS HTML Full Text PDF Full Text

Antimicrobial photodynamic therapy in the nonsurgical treatment of periodontitis in patients with HIV infection: a systematic review and meta-analysis.

Saved in:
Bibliographic Details
Title: Antimicrobial photodynamic therapy in the nonsurgical treatment of periodontitis in patients with HIV infection: a systematic review and meta-analysis.
Authors: Nunes, Gabriel Pereira1 (AUTHOR) Gabriel.p.nunes@unesp.br, de Oliveira Alves, Renata1 (AUTHOR), Ragghianti, Matheus Henrique Faccioli1 (AUTHOR), Martins, Tamires Passadori1 (AUTHOR), dos Reis Prado, Alexandre Henrique2 (AUTHOR), Nunes, Larissa Pereira1 (AUTHOR), Poli, Maria Clara Faria1 (AUTHOR), Silva, Arles Naisa Amaral3 (AUTHOR), Benetti, Francine2 (AUTHOR)
Source: Lasers in Medical Science. 6/12/2024, Vol. 39 Issue 1, p1-19. 19p.
Subjects: HIV infections, Photodynamic therapy, HIV, Random effects model, Periodontitis
Abstract: The aim of this systematic review and meta-analysis (SRM) was to evaluate the effectiveness of the adjunctive use of antimicrobial photodynamic therapy (aPDT) in non-surgical periodontal treatment (NSPT) in subjects with Human Immunodeficiency Virus (HIV) and periodontitis. This SRM was registered in PROSPERO (CRD42023410180) and followed the guidelines of PRISMA 2020. Searches were performed in different electronic databases. Risk of bias was performed using the Cochrane Risk of Bias tool (RoB 2.0) for randomized clinical trials (RCT). Meta-analysis was performed using Rev Man software. The mean difference (MD) measure of effect was calculated, the random effect model was applied with a 95% confidence interval, and heterogeneity was tested by the I2 index. The certainty of the evidence was rated using GRADE. A total of 1118 records were screened, and four studies were included. There was a greater reduction in the microbial load of periodontopathogens after NSPT with aPDT. Meta-analysis showed that probing depth (post 3 and 6 months) and clinical attachment loss (post 6 months) were lower for the aPDT-treated group than the NSPT alone: MD -0.39 [-0.74; -0.05], p = 0.02; MD -0.70 [-0.99; -0.41], p < 0.0001; MD -0.84 [-1,34; -0.34], p = 0.0001, respectively. Overall, the studies had a low risk of bias and, the certainty of evidence was rated as moderate. It is suggested that aPDT is a promising adjuvant therapy, showing efficacy in the reduction of the microbial load and in some clinical parameters of individuals with periodontitis and HIV. [ABSTRACT FROM AUTHOR]
Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: egs
DbLabel: Engineering Source
An: 177816626
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Antimicrobial photodynamic therapy in the nonsurgical treatment of periodontitis in patients with HIV infection: a systematic review and meta-analysis.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Nunes%2C+Gabriel+Pereira%22&quot;&gt;Nunes, Gabriel Pereira&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; Gabriel.p.nunes@unesp.br&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22de+Oliveira+Alves%2C+Renata%22&quot;&gt;de Oliveira Alves, Renata&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ragghianti%2C+Matheus+Henrique+Faccioli%22&quot;&gt;Ragghianti, Matheus Henrique Faccioli&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Martins%2C+Tamires+Passadori%22&quot;&gt;Martins, Tamires Passadori&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22dos+Reis+Prado%2C+Alexandre+Henrique%22&quot;&gt;dos Reis Prado, Alexandre Henrique&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Nunes%2C+Larissa+Pereira%22&quot;&gt;Nunes, Larissa Pereira&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Poli%2C+Maria+Clara+Faria%22&quot;&gt;Poli, Maria Clara Faria&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Silva%2C+Arles+Naisa+Amaral%22&quot;&gt;Silva, Arles Naisa Amaral&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Benetti%2C+Francine%22&quot;&gt;Benetti, Francine&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt; (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Lasers+in+Medical+Science%22&quot;&gt;Lasers in Medical Science&lt;/searchLink&gt;. 6/12/2024, Vol. 39 Issue 1, p1-19. 19p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22HIV+infections%22&quot;&gt;HIV infections&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Photodynamic+therapy%22&quot;&gt;Photodynamic therapy&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22HIV%22&quot;&gt;HIV&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Random+effects+model%22&quot;&gt;Random effects model&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Periodontitis%22&quot;&gt;Periodontitis&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The aim of this systematic review and meta-analysis (SRM) was to evaluate the effectiveness of the adjunctive use of antimicrobial photodynamic therapy (aPDT) in non-surgical periodontal treatment (NSPT) in subjects with Human Immunodeficiency Virus (HIV) and periodontitis. This SRM was registered in PROSPERO (CRD42023410180) and followed the guidelines of PRISMA 2020. Searches were performed in different electronic databases. Risk of bias was performed using the Cochrane Risk of Bias tool (RoB 2.0) for randomized clinical trials (RCT). Meta-analysis was performed using Rev Man software. The mean difference (MD) measure of effect was calculated, the random effect model was applied with a 95% confidence interval, and heterogeneity was tested by the I2 index. The certainty of the evidence was rated using GRADE. A total of 1118 records were screened, and four studies were included. There was a greater reduction in the microbial load of periodontopathogens after NSPT with aPDT. Meta-analysis showed that probing depth (post 3 and 6 months) and clinical attachment loss (post 6 months) were lower for the aPDT-treated group than the NSPT alone: MD -0.39 [-0.74; -0.05], p = 0.02; MD -0.70 [-0.99; -0.41], p &lt; 0.0001; MD -0.84 [-1,34; -0.34], p = 0.0001, respectively. Overall, the studies had a low risk of bias and, the certainty of evidence was rated as moderate. It is suggested that aPDT is a promising adjuvant therapy, showing efficacy in the reduction of the microbial load and in some clinical parameters of individuals with periodontitis and HIV. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=177816626
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s10103-024-04087-y
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 19
        StartPage: 1
    Subjects:
      – SubjectFull: HIV infections
        Type: general
      – SubjectFull: Photodynamic therapy
        Type: general
      – SubjectFull: HIV
        Type: general
      – SubjectFull: Random effects model
        Type: general
      – SubjectFull: Periodontitis
        Type: general
    Titles:
      – TitleFull: Antimicrobial photodynamic therapy in the nonsurgical treatment of periodontitis in patients with HIV infection: a systematic review and meta-analysis.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Nunes, Gabriel Pereira
      – PersonEntity:
          Name:
            NameFull: de Oliveira Alves, Renata
      – PersonEntity:
          Name:
            NameFull: Ragghianti, Matheus Henrique Faccioli
      – PersonEntity:
          Name:
            NameFull: Martins, Tamires Passadori
      – PersonEntity:
          Name:
            NameFull: dos Reis Prado, Alexandre Henrique
      – PersonEntity:
          Name:
            NameFull: Nunes, Larissa Pereira
      – PersonEntity:
          Name:
            NameFull: Poli, Maria Clara Faria
      – PersonEntity:
          Name:
            NameFull: Silva, Arles Naisa Amaral
      – PersonEntity:
          Name:
            NameFull: Benetti, Francine
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 12
              M: 06
              Text: 6/12/2024
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-print
              Value: 02688921
          Numbering:
            – Type: volume
              Value: 39
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Lasers in Medical Science
              Type: main
ResultId 1