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Immune-related visual dysfunction in thyroid eye disease: a combined orbital and brain neuroimaging study.

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Title: Immune-related visual dysfunction in thyroid eye disease: a combined orbital and brain neuroimaging study.
Authors: Zhang, Haiyang1,2 (AUTHOR), Liu, Yuting1,2 (AUTHOR), Jiang, Mengda3 (AUTHOR), Shen, Feiyang1,2 (AUTHOR), Zhu, Tianyi1,2 (AUTHOR), Xia, Duojin4 (AUTHOR), Li, Jipeng1,2 (AUTHOR), Fang, Sijie1,2 (AUTHOR), Li, Yinwei1,2 (AUTHOR), Sun, Jing1,2 (AUTHOR), Song, Xuefei1,2 (AUTHOR) songxuefei@shsmu.edu.cn, Zhou, Huifang1,2 (AUTHOR) fangzzfang@163.com, Fan, Xianqun1,2 (AUTHOR) fanxq@sjtu.edu.cn
Source: European Radiology. Jul2024, Vol. 34 Issue 7, p4516-4526. 11p.
Subjects: Thyroid eye disease, Large-scale brain networks, Thyroid diseases, Orbital diseases, Magnetic resonance imaging, Central nervous system
Abstract: Objectives: To investigate the pathological interplay between immunity and the visual processing system (VPS) in thyroid eye disease (TED). Methods: A total of 24 active patients (AP), 26 inactive patients (IP) of TED, and 27 healthy controls (HCs) were enrolled. Orbital magnetic resonance imaging (MRI) and resting-state functional MRI (rs-fMRI) were conducted for each participant. Multiple MRI parameters of the intraorbital optic nerve (ON) were assessed. The amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) were calculated. Correlation analyses were carried out on the above parameters and clinical characteristics. Results: Visual functioning scores differentiated between the AP and IP groups. The ON subarachnoid space and ON sheath diameter were significantly higher in AP than in IP. Six vision-related brain regions were identified in TED patients compared with HCs, including right calcarine (CAL.R), right cuneus (CUN.R), left postcentral gyrus (PoCG.L), right middle temporal gyrus (MTG.R), left superior frontal gyrus (SFG.L), and left caudate (CAU.L). The brain activity of MTG.R, SFG.L, and CAU.L differentiated between the AP and IP groups. The correlation analysis revealed a close association among the vision-related brain regions, MRI parameters of ON, and clinical characteristics in AP and IP, respectively. Conclusions: Combined orbital and brain neuroimaging revealed abnormalities of the VPS in TED, which had a close correlation with immune statuses. Vision-related brain regions in TED might be possibly altered by peripheral immunity via a direct or indirect approach. Clinical relevance statement: The discovery of this study explained the disparity of visual dysfunction in TED patients with different immune statuses. With the uncovered neuroimaging markers, early detection and intervention of visual dysfunction could be achieved and potentially benefit TED patients. Key Points: • Patients with different immune statuses of thyroid eye disease varied in the presentation of visual dysfunction. • The combined orbital and brain neuroimaging study identified six altered vision-related brain regions, which had a significant correlation with the MRI parameters of the intraorbital optic nerve and immunological characteristics. • Peripheral immunity might possibly give rise to alterations in the central nervous system part of the visual processing system via a direct or indirect approach. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Immune-related visual dysfunction in thyroid eye disease: a combined orbital and brain neuroimaging study.
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  Data: <searchLink fieldCode="AR" term="%22Zhang%2C+Haiyang%22">Zhang, Haiyang</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Yuting%22">Liu, Yuting</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jiang%2C+Mengda%22">Jiang, Mengda</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shen%2C+Feiyang%22">Shen, Feiyang</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhu%2C+Tianyi%22">Zhu, Tianyi</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xia%2C+Duojin%22">Xia, Duojin</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Jipeng%22">Li, Jipeng</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fang%2C+Sijie%22">Fang, Sijie</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Yinwei%22">Li, Yinwei</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sun%2C+Jing%22">Sun, Jing</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Song%2C+Xuefei%22">Song, Xuefei</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> songxuefei@shsmu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Zhou%2C+Huifang%22">Zhou, Huifang</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> fangzzfang@163.com</i><br /><searchLink fieldCode="AR" term="%22Fan%2C+Xianqun%22">Fan, Xianqun</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> fanxq@sjtu.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Jul2024, Vol. 34 Issue 7, p4516-4526. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Thyroid+eye+disease%22">Thyroid eye disease</searchLink><br /><searchLink fieldCode="DE" term="%22Large-scale+brain+networks%22">Large-scale brain networks</searchLink><br /><searchLink fieldCode="DE" term="%22Thyroid+diseases%22">Thyroid diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Orbital+diseases%22">Orbital diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Central+nervous+system%22">Central nervous system</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objectives: To investigate the pathological interplay between immunity and the visual processing system (VPS) in thyroid eye disease (TED). Methods: A total of 24 active patients (AP), 26 inactive patients (IP) of TED, and 27 healthy controls (HCs) were enrolled. Orbital magnetic resonance imaging (MRI) and resting-state functional MRI (rs-fMRI) were conducted for each participant. Multiple MRI parameters of the intraorbital optic nerve (ON) were assessed. The amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) were calculated. Correlation analyses were carried out on the above parameters and clinical characteristics. Results: Visual functioning scores differentiated between the AP and IP groups. The ON subarachnoid space and ON sheath diameter were significantly higher in AP than in IP. Six vision-related brain regions were identified in TED patients compared with HCs, including right calcarine (CAL.R), right cuneus (CUN.R), left postcentral gyrus (PoCG.L), right middle temporal gyrus (MTG.R), left superior frontal gyrus (SFG.L), and left caudate (CAU.L). The brain activity of MTG.R, SFG.L, and CAU.L differentiated between the AP and IP groups. The correlation analysis revealed a close association among the vision-related brain regions, MRI parameters of ON, and clinical characteristics in AP and IP, respectively. Conclusions: Combined orbital and brain neuroimaging revealed abnormalities of the VPS in TED, which had a close correlation with immune statuses. Vision-related brain regions in TED might be possibly altered by peripheral immunity via a direct or indirect approach. Clinical relevance statement: The discovery of this study explained the disparity of visual dysfunction in TED patients with different immune statuses. With the uncovered neuroimaging markers, early detection and intervention of visual dysfunction could be achieved and potentially benefit TED patients. Key Points: • Patients with different immune statuses of thyroid eye disease varied in the presentation of visual dysfunction. • The combined orbital and brain neuroimaging study identified six altered vision-related brain regions, which had a significant correlation with the MRI parameters of the intraorbital optic nerve and immunological characteristics. • Peripheral immunity might possibly give rise to alterations in the central nervous system part of the visual processing system via a direct or indirect approach. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00330-023-10309-8
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        Text: English
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      – SubjectFull: Thyroid eye disease
        Type: general
      – SubjectFull: Large-scale brain networks
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      – SubjectFull: Thyroid diseases
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      – SubjectFull: Orbital diseases
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      – SubjectFull: Magnetic resonance imaging
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      – SubjectFull: Central nervous system
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      – TitleFull: Immune-related visual dysfunction in thyroid eye disease: a combined orbital and brain neuroimaging study.
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              Text: Jul2024
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