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Poly(2-isopropenyl-2-oxazoline) as a Versatile Functional Polymer for Biomedical Applications.

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Title: Poly(2-isopropenyl-2-oxazoline) as a Versatile Functional Polymer for Biomedical Applications.
Authors: Kronek, Juraj1 (AUTHOR) alzbeta.minarcikova@savba.sk, Minarčíková, Alžbeta1 (AUTHOR) zuzana.kronekova@savba.sk, Kroneková, Zuzana1 (AUTHOR) upolmoma@savba.sk, Majerčíková, Monika1 (AUTHOR), Strasser, Paul2 (AUTHOR) paul.strasser@jku.at, Teasdale, Ian2 (AUTHOR) ian.teasdale@jku.at
Source: Polymers (20734360). Jun2024, Vol. 16 Issue 12, p1708. 22p.
Subjects: Medical polymers, Reactive polymers, Living polymerization, Addition polymerization, Cationic polymers, Tissue engineering
Abstract: Functional polymers play an important role in various biomedical applications. From many choices, poly(2-isopropenyl-2-oxazoline) (PIPOx) represents a promising reactive polymer with great potential in various biomedical applications. PIPOx, with pendant reactive 2-oxazoline groups, can be readily prepared in a controllable manner via several controlled/living polymerization methods, such as living anionic polymerization, atom transfer radical polymerization (ATRP), reversible addition–fragmentation transfer (RAFT) or rare earth metal-mediated group transfer polymerization. The reactivity of pendant 2-oxazoline allows selective reactions with thiol and carboxylic group-containing compounds without the presence of any catalyst. Moreover, PIPOx has been demonstrated to be a non-cytotoxic polymer with immunomodulative properties. Post-polymerization functionalization of PIPOx has been used for the preparation of thermosensitive or cationic polymers, drug conjugates, hydrogels, brush-like materials, and polymer coatings available for drug and gene delivery, tissue engineering, blood-like materials, antimicrobial materials, and many others. This mini-review covers new achievements in PIPOx synthesis, reactivity, and use in biomedical applications. [ABSTRACT FROM AUTHOR]
Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Poly(2-isopropenyl-2-oxazoline) as a Versatile Functional Polymer for Biomedical Applications.
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  Data: <searchLink fieldCode="AR" term="%22Kronek%2C+Juraj%22">Kronek, Juraj</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> alzbeta.minarcikova@savba.sk</i><br /><searchLink fieldCode="AR" term="%22Minarčíková%2C+Alžbeta%22">Minarčíková, Alžbeta</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> zuzana.kronekova@savba.sk</i><br /><searchLink fieldCode="AR" term="%22Kroneková%2C+Zuzana%22">Kroneková, Zuzana</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> upolmoma@savba.sk</i><br /><searchLink fieldCode="AR" term="%22Majerčíková%2C+Monika%22">Majerčíková, Monika</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Strasser%2C+Paul%22">Strasser, Paul</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> paul.strasser@jku.at</i><br /><searchLink fieldCode="AR" term="%22Teasdale%2C+Ian%22">Teasdale, Ian</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> ian.teasdale@jku.at</i>
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  Data: <searchLink fieldCode="JN" term="%22Polymers+%2820734360%29%22">Polymers (20734360)</searchLink>. Jun2024, Vol. 16 Issue 12, p1708. 22p.
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  Data: <searchLink fieldCode="DE" term="%22Medical+polymers%22">Medical polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Reactive+polymers%22">Reactive polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Living+polymerization%22">Living polymerization</searchLink><br /><searchLink fieldCode="DE" term="%22Addition+polymerization%22">Addition polymerization</searchLink><br /><searchLink fieldCode="DE" term="%22Cationic+polymers%22">Cationic polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Tissue+engineering%22">Tissue engineering</searchLink>
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  Data: Functional polymers play an important role in various biomedical applications. From many choices, poly(2-isopropenyl-2-oxazoline) (PIPOx) represents a promising reactive polymer with great potential in various biomedical applications. PIPOx, with pendant reactive 2-oxazoline groups, can be readily prepared in a controllable manner via several controlled/living polymerization methods, such as living anionic polymerization, atom transfer radical polymerization (ATRP), reversible addition–fragmentation transfer (RAFT) or rare earth metal-mediated group transfer polymerization. The reactivity of pendant 2-oxazoline allows selective reactions with thiol and carboxylic group-containing compounds without the presence of any catalyst. Moreover, PIPOx has been demonstrated to be a non-cytotoxic polymer with immunomodulative properties. Post-polymerization functionalization of PIPOx has been used for the preparation of thermosensitive or cationic polymers, drug conjugates, hydrogels, brush-like materials, and polymer coatings available for drug and gene delivery, tissue engineering, blood-like materials, antimicrobial materials, and many others. This mini-review covers new achievements in PIPOx synthesis, reactivity, and use in biomedical applications. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Text: English
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      – SubjectFull: Living polymerization
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      – SubjectFull: Addition polymerization
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      – SubjectFull: Cationic polymers
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      – SubjectFull: Tissue engineering
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      – TitleFull: Poly(2-isopropenyl-2-oxazoline) as a Versatile Functional Polymer for Biomedical Applications.
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            NameFull: Minarčíková, Alžbeta
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              Text: Jun2024
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