Poly(2-isopropenyl-2-oxazoline) as a Versatile Functional Polymer for Biomedical Applications.
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| Title: | Poly(2-isopropenyl-2-oxazoline) as a Versatile Functional Polymer for Biomedical Applications. |
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| Authors: | Kronek, Juraj1 (AUTHOR) alzbeta.minarcikova@savba.sk, Minarčíková, Alžbeta1 (AUTHOR) zuzana.kronekova@savba.sk, Kroneková, Zuzana1 (AUTHOR) upolmoma@savba.sk, Majerčíková, Monika1 (AUTHOR), Strasser, Paul2 (AUTHOR) paul.strasser@jku.at, Teasdale, Ian2 (AUTHOR) ian.teasdale@jku.at |
| Source: | Polymers (20734360). Jun2024, Vol. 16 Issue 12, p1708. 22p. |
| Subjects: | Medical polymers, Reactive polymers, Living polymerization, Addition polymerization, Cationic polymers, Tissue engineering |
| Abstract: | Functional polymers play an important role in various biomedical applications. From many choices, poly(2-isopropenyl-2-oxazoline) (PIPOx) represents a promising reactive polymer with great potential in various biomedical applications. PIPOx, with pendant reactive 2-oxazoline groups, can be readily prepared in a controllable manner via several controlled/living polymerization methods, such as living anionic polymerization, atom transfer radical polymerization (ATRP), reversible addition–fragmentation transfer (RAFT) or rare earth metal-mediated group transfer polymerization. The reactivity of pendant 2-oxazoline allows selective reactions with thiol and carboxylic group-containing compounds without the presence of any catalyst. Moreover, PIPOx has been demonstrated to be a non-cytotoxic polymer with immunomodulative properties. Post-polymerization functionalization of PIPOx has been used for the preparation of thermosensitive or cationic polymers, drug conjugates, hydrogels, brush-like materials, and polymer coatings available for drug and gene delivery, tissue engineering, blood-like materials, antimicrobial materials, and many others. This mini-review covers new achievements in PIPOx synthesis, reactivity, and use in biomedical applications. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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