Physics and small‐scale dosimetry of α$\alpha$‐emitters for targeted radionuclide therapy: The case of 211At$^{211}{\rm At}$.
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| Title: | Physics and small‐scale dosimetry of α$\alpha$‐emitters for targeted radionuclide therapy: The case of 211At$^{211}{\rm At}$. |
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| Authors: | Alcocer‐Ávila, Mario Enrique1 (AUTHOR) m.alcocer-avila@ip2i.in2p3.fr, Larouze, Alexandre1 (AUTHOR), Groetz, Jean‐Emmanuel2 (AUTHOR), Hindié, Elif3,4 (AUTHOR), Champion, Christophe1 (AUTHOR) |
| Source: | Medical Physics. Jul2024, Vol. 51 Issue 7, p5007-5019. 13p. |
| Subjects: | Radioisotopes, Monte Carlo method, Physics, Absorbed dose, Water vapor, DNA |
| Abstract: | Background: Monte Carlo simulations have been considered for a long time the gold standard for dose calculations in conventional radiotherapy and are currently being applied for the same purpose in innovative radiotherapy techniques such as targeted radionuclide therapy (TRT). Purpose: We present in this work a benchmarking study of the latest version of the Transport d'Ions Lourds Dans l'Aqua & Vivo (TILDA‐V) Monte Carlo track structure code, highlighting its capabilities for describing the full slowing down of α$\alpha$‐particles in water and the energy deposited in cells by α$\alpha$‐emitters in the context of TRT. Methods: We performed radiation transport simulations of α$\alpha$‐particles (10 keV u−1${\rm u}^{-1}$–100 MeV u−1${\rm u}^{-1}$) in water with TILDA‐V and the Particle and Heavy Ion Transport code System (PHITS) version 3.33. We compared the predictions of each code in terms of track parameters (stopping power, range and radial dose profiles) and cellular S‐values of the promising radionuclide astatine‐211 (211At$^{211}{\rm At}$). Additional comparisons were made with available data in the literature. Results: The stopping power, range and radial dose profiles of α$\alpha$‐particles computed with TILDA‐V were in excellent agreement with other calculations and available data. Overall, minor differences with PHITS were ascribed to phase effects, that is, related to the use of interaction cross sections computed for water vapor or liquid water. However, important discrepancies were observed in the radial dose profiles of monoenergetic α$\alpha$‐particles, for which PHITS results showed a large underestimation of the absorbed dose compared to other codes and experimental data. The cellular S‐values of 211At$^{211}{\rm At}$ computed with TILDA‐V agreed within 4% with the values predicted by PHITS and MIRDcell. Conclusions: The validation of the TILDA‐V code presented in this work opens the possibility to use it as an accurate simulation tool for investigating the interaction of α$\alpha$‐particles in biological media down to the nanometer scale in the context of medical research. The code may help nuclear medicine physicians in their choice of α$\alpha$‐emitters for TRT. Further research will focus on the application of TILDA‐V for quantifying radioinduced damage on the deoxyribonucleic acid (DNA) molecule. [ABSTRACT FROM AUTHOR] |
| Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: egs DbLabel: Engineering Source An: 178332890 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Physics and small‐scale dosimetry of α$\alpha$‐emitters for targeted radionuclide therapy: The case of 211At$^{211}{\rm At}$. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Alcocer‐Ávila%2C+Mario+Enrique%22">Alcocer‐Ávila, Mario Enrique</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> m.alcocer-avila@ip2i.in2p3.fr</i><br /><searchLink fieldCode="AR" term="%22Larouze%2C+Alexandre%22">Larouze, Alexandre</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Groetz%2C+Jean‐Emmanuel%22">Groetz, Jean‐Emmanuel</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hindié%2C+Elif%22">Hindié, Elif</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Champion%2C+Christophe%22">Champion, Christophe</searchLink><relatesTo>1</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Medical+Physics%22">Medical Physics</searchLink>. Jul2024, Vol. 51 Issue 7, p5007-5019. 13p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Radioisotopes%22">Radioisotopes</searchLink><br /><searchLink fieldCode="DE" term="%22Monte+Carlo+method%22">Monte Carlo method</searchLink><br /><searchLink fieldCode="DE" term="%22Physics%22">Physics</searchLink><br /><searchLink fieldCode="DE" term="%22Absorbed+dose%22">Absorbed dose</searchLink><br /><searchLink fieldCode="DE" term="%22Water+vapor%22">Water vapor</searchLink><br /><searchLink fieldCode="DE" term="%22DNA%22">DNA</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: Monte Carlo simulations have been considered for a long time the gold standard for dose calculations in conventional radiotherapy and are currently being applied for the same purpose in innovative radiotherapy techniques such as targeted radionuclide therapy (TRT). Purpose: We present in this work a benchmarking study of the latest version of the Transport d'Ions Lourds Dans l'Aqua & Vivo (TILDA‐V) Monte Carlo track structure code, highlighting its capabilities for describing the full slowing down of α$\alpha$‐particles in water and the energy deposited in cells by α$\alpha$‐emitters in the context of TRT. Methods: We performed radiation transport simulations of α$\alpha$‐particles (10 keV u−1${\rm u}^{-1}$–100 MeV u−1${\rm u}^{-1}$) in water with TILDA‐V and the Particle and Heavy Ion Transport code System (PHITS) version 3.33. We compared the predictions of each code in terms of track parameters (stopping power, range and radial dose profiles) and cellular S‐values of the promising radionuclide astatine‐211 (211At$^{211}{\rm At}$). Additional comparisons were made with available data in the literature. Results: The stopping power, range and radial dose profiles of α$\alpha$‐particles computed with TILDA‐V were in excellent agreement with other calculations and available data. Overall, minor differences with PHITS were ascribed to phase effects, that is, related to the use of interaction cross sections computed for water vapor or liquid water. However, important discrepancies were observed in the radial dose profiles of monoenergetic α$\alpha$‐particles, for which PHITS results showed a large underestimation of the absorbed dose compared to other codes and experimental data. The cellular S‐values of 211At$^{211}{\rm At}$ computed with TILDA‐V agreed within 4% with the values predicted by PHITS and MIRDcell. Conclusions: The validation of the TILDA‐V code presented in this work opens the possibility to use it as an accurate simulation tool for investigating the interaction of α$\alpha$‐particles in biological media down to the nanometer scale in the context of medical research. The code may help nuclear medicine physicians in their choice of α$\alpha$‐emitters for TRT. Further research will focus on the application of TILDA‐V for quantifying radioinduced damage on the deoxyribonucleic acid (DNA) molecule. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mp.17016 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 5007 Subjects: – SubjectFull: Radioisotopes Type: general – SubjectFull: Monte Carlo method Type: general – SubjectFull: Physics Type: general – SubjectFull: Absorbed dose Type: general – SubjectFull: Water vapor Type: general – SubjectFull: DNA Type: general Titles: – TitleFull: Physics and small‐scale dosimetry of α$\alpha$‐emitters for targeted radionuclide therapy: The case of 211At$^{211}{\rm At}$. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Alcocer‐Ávila, Mario Enrique – PersonEntity: Name: NameFull: Larouze, Alexandre – PersonEntity: Name: NameFull: Groetz, Jean‐Emmanuel – PersonEntity: Name: NameFull: Hindié, Elif – PersonEntity: Name: NameFull: Champion, Christophe IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 00942405 Numbering: – Type: volume Value: 51 – Type: issue Value: 7 Titles: – TitleFull: Medical Physics Type: main |
| ResultId | 1 |
