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Whole‐cerebrum guanidino and amide CEST mapping at 3 T by a 3D stack‐of‐spirals gradient echo acquisition.

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Title: Whole‐cerebrum guanidino and amide CEST mapping at 3 T by a 3D stack‐of‐spirals gradient echo acquisition.
Authors: Wang, Kexin1,2 (AUTHOR), Ju, Licheng1,3 (AUTHOR), Song, Yulu3 (AUTHOR), Blair, Lindsay4 (AUTHOR), Xie, Kevin1 (AUTHOR), Liu, Claire1 (AUTHOR), Li, Anna M1 (AUTHOR), Zhu, Dan1,3 (AUTHOR), Xu, Feng1,3 (AUTHOR), Liu, Guanshu1,3 (AUTHOR), Heo, Hye‐Young1,3 (AUTHOR), Yadav, Nirbhay Narayan1,3 (AUTHOR), Oeltzschner, Georg1,3 (AUTHOR), Edden, Richard A. E.1,3 (AUTHOR), Qin, Qin1,3 (AUTHOR), Kamson, David Olayinka4 (AUTHOR), Xu, Jiadi1,3 (AUTHOR) jxu37@jh.edu
Source: Magnetic Resonance in Medicine. Oct2024, Vol. 92 Issue 4, p1456-1470. 15p.
Subjects: Gray matter (Nerve tissue), White matter (Nerve tissue), Statistical reliability, Magnetization transfer, Statistical correlation
Abstract: Purpose: To develop a 3D, high‐sensitivity CEST mapping technique based on the 3D stack‐of‐spirals (SOS) gradient echo readout, the proposed approach was compared with conventional acquisition techniques and evaluated for its efficacy in concurrently mapping of guanidino (Guan) and amide CEST in human brain at 3 T, leveraging the polynomial Lorentzian line‐shape fitting (PLOF) method. Methods: Saturation time and recovery delay were optimized to achieve maximum CEST time efficiency. The 3DSOS method was compared with segmented 3D EPI (3DEPI), turbo spin echo, and gradient‐ and spin‐echo techniques. Image quality, temporal SNR (tSNR), and test–retest reliability were assessed. Maps of Guan and amide CEST derived from 3DSOS were demonstrated on a low‐grade glioma patient. Results: The optimized recovery delay/saturation time was determined to be 1.4/2 s for Guan and amide CEST. In addition to nearly doubling the slice number, the gradient echo techniques also outperformed spin echo sequences in tSNR: 3DEPI (193.8 ± 6.6), 3DSOS (173.9 ± 5.6), and GRASE (141.0 ± 2.7). 3DSOS, compared with 3DEPI, demonstrated comparable GuanCEST signal in gray matter (GM) (3DSOS: [2.14%–2.59%] vs. 3DEPI: [2.15%–2.61%]), and white matter (WM) (3DSOS: [1.49%–2.11%] vs. 3DEPI: [1.64%–2.09%]). 3DSOS also achieves significantly higher amideCEST in both GM (3DSOS: [2.29%–3.00%] vs. 3DEPI: [2.06%–2.92%]) and WM (3DSOS: [2.23%–2.66%] vs. 3DEPI: [1.95%–2.57%]). 3DSOS outperforms 3DEPI in terms of scan–rescan reliability (correlation coefficient: 3DSOS: 0.58–0.96 vs. 3DEPI: −0.02 to 0.75) and robustness to motion as well. Conclusion: The 3DSOS CEST technique shows promise for whole‐cerebrum CEST imaging, offering uniform contrast and robustness against motion artifacts. [ABSTRACT FROM AUTHOR]
Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Whole‐cerebrum guanidino and amide CEST mapping at 3 T by a 3D stack‐of‐spirals gradient echo acquisition.
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  Data: <searchLink fieldCode="AR" term="%22Wang%2C+Kexin%22">Wang, Kexin</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ju%2C+Licheng%22">Ju, Licheng</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Song%2C+Yulu%22">Song, Yulu</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Blair%2C+Lindsay%22">Blair, Lindsay</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xie%2C+Kevin%22">Xie, Kevin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Claire%22">Liu, Claire</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Anna+M%22">Li, Anna M</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhu%2C+Dan%22">Zhu, Dan</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xu%2C+Feng%22">Xu, Feng</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Guanshu%22">Liu, Guanshu</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Heo%2C+Hye‐Young%22">Heo, Hye‐Young</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yadav%2C+Nirbhay+Narayan%22">Yadav, Nirbhay Narayan</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Oeltzschner%2C+Georg%22">Oeltzschner, Georg</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Edden%2C+Richard+A%2E+E%2E%22">Edden, Richard A. E.</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Qin%2C+Qin%22">Qin, Qin</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kamson%2C+David+Olayinka%22">Kamson, David Olayinka</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xu%2C+Jiadi%22">Xu, Jiadi</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> jxu37@jh.edu</i>
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  Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Oct2024, Vol. 92 Issue 4, p1456-1470. 15p.
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  Data: <searchLink fieldCode="DE" term="%22Gray+matter+%28Nerve+tissue%29%22">Gray matter (Nerve tissue)</searchLink><br /><searchLink fieldCode="DE" term="%22White+matter+%28Nerve+tissue%29%22">White matter (Nerve tissue)</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+reliability%22">Statistical reliability</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetization+transfer%22">Magnetization transfer</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+correlation%22">Statistical correlation</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: To develop a 3D, high‐sensitivity CEST mapping technique based on the 3D stack‐of‐spirals (SOS) gradient echo readout, the proposed approach was compared with conventional acquisition techniques and evaluated for its efficacy in concurrently mapping of guanidino (Guan) and amide CEST in human brain at 3 T, leveraging the polynomial Lorentzian line‐shape fitting (PLOF) method. Methods: Saturation time and recovery delay were optimized to achieve maximum CEST time efficiency. The 3DSOS method was compared with segmented 3D EPI (3DEPI), turbo spin echo, and gradient‐ and spin‐echo techniques. Image quality, temporal SNR (tSNR), and test–retest reliability were assessed. Maps of Guan and amide CEST derived from 3DSOS were demonstrated on a low‐grade glioma patient. Results: The optimized recovery delay/saturation time was determined to be 1.4/2 s for Guan and amide CEST. In addition to nearly doubling the slice number, the gradient echo techniques also outperformed spin echo sequences in tSNR: 3DEPI (193.8 ± 6.6), 3DSOS (173.9 ± 5.6), and GRASE (141.0 ± 2.7). 3DSOS, compared with 3DEPI, demonstrated comparable GuanCEST signal in gray matter (GM) (3DSOS: [2.14%–2.59%] vs. 3DEPI: [2.15%–2.61%]), and white matter (WM) (3DSOS: [1.49%–2.11%] vs. 3DEPI: [1.64%–2.09%]). 3DSOS also achieves significantly higher amideCEST in both GM (3DSOS: [2.29%–3.00%] vs. 3DEPI: [2.06%–2.92%]) and WM (3DSOS: [2.23%–2.66%] vs. 3DEPI: [1.95%–2.57%]). 3DSOS outperforms 3DEPI in terms of scan–rescan reliability (correlation coefficient: 3DSOS: 0.58–0.96 vs. 3DEPI: −0.02 to 0.75) and robustness to motion as well. Conclusion: The 3DSOS CEST technique shows promise for whole‐cerebrum CEST imaging, offering uniform contrast and robustness against motion artifacts. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1002/mrm.30134
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      – Code: eng
        Text: English
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        PageCount: 15
        StartPage: 1456
    Subjects:
      – SubjectFull: Gray matter (Nerve tissue)
        Type: general
      – SubjectFull: White matter (Nerve tissue)
        Type: general
      – SubjectFull: Statistical reliability
        Type: general
      – SubjectFull: Magnetization transfer
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      – SubjectFull: Statistical correlation
        Type: general
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      – TitleFull: Whole‐cerebrum guanidino and amide CEST mapping at 3 T by a 3D stack‐of‐spirals gradient echo acquisition.
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              M: 10
              Text: Oct2024
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