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Diffusion‐weighted MR spectroscopy of the prostate.

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Title: Diffusion‐weighted MR spectroscopy of the prostate.
Authors: Stamatelatou, Angeliki1 (AUTHOR), Rizzo, Rudy2,3,4 (AUTHOR), Simsek, Kadir5,6 (AUTHOR), van Asten, Jack J A1 (AUTHOR), Heerschap, Arend1 (AUTHOR), Scheenen, Tom1 (AUTHOR), Kreis, Roland2,3,7 (AUTHOR) roland.kreis@unibe.ch
Source: Magnetic Resonance in Medicine. Oct2024, Vol. 92 Issue 4, p1323-1337. 15p.
Subjects: Proton magnetic resonance spectroscopy, Prostate, Spectrometry, Stromal cells, Diffusion coefficients, Protein binding
Abstract: Purpose: Prostate tissue has a complex microstructure, mainly composed of epithelial and stromal cells, and of extracellular (acinar‐luminal) spaces. Diffusion‐weighted MR spectroscopy (DW‐MRS) is ideally suited to explore complex microstructure in vivo with metabolites selectively distributed in different subspaces. To date, this technique has been applied to brain and muscle. This study presents the development and pioneering utilization of 1H‐DW‐MRS in the prostate, accompanied by in vitro studies to support interpretations of in vivo findings. Methods: Nine healthy volunteers underwent a prostate MR examination (mean age, 56 years; range, 31–66). Metabolic complexation was studied in vitro using solutions with major compounds found in prostatic fluid of the lumen. DW‐MRS was performed at 3 T with a non–water‐suppressed single‐voxel sequence with metabolite‐cycling to concurrently measure metabolite and water signals. The water signal was used in postprocessing as a reference in a motion‐compensation scheme. The spectra were fitted simultaneously in the spectral and diffusion‐weighting dimensions. Apparent diffusion coefficients (ADCs) were derived by fitting signal decays that were assumed to be mono‐exponential for metabolites and biexponential for water. Results: DW‐MRS of the prostate revealed relatively low ADCs for Cho and Cr compounds, aligning with their intracellular location and higher ADCs for citrate and spermine supporting their luminal origin. In vitro assessments of the ADCs of citrate and spermine demonstrated their complex formation and protein binding. Tissue concentrations of MRS‐detectable metabolites were as expected for the voxel location. Conclusions: This work successfully demonstrates the feasibility of 1H‐DW‐MRS of the prostate and its potential for providing valuable microstructural information. [ABSTRACT FROM AUTHOR]
Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Diffusion‐weighted MR spectroscopy of the prostate.
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  Data: <searchLink fieldCode="AR" term="%22Stamatelatou%2C+Angeliki%22">Stamatelatou, Angeliki</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rizzo%2C+Rudy%22">Rizzo, Rudy</searchLink><relatesTo>2,3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Simsek%2C+Kadir%22">Simsek, Kadir</searchLink><relatesTo>5,6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22van+Asten%2C+Jack+J+A%22">van Asten, Jack J A</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Heerschap%2C+Arend%22">Heerschap, Arend</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Scheenen%2C+Tom%22">Scheenen, Tom</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kreis%2C+Roland%22">Kreis, Roland</searchLink><relatesTo>2,3,7</relatesTo> (AUTHOR)<i> roland.kreis@unibe.ch</i>
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  Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Oct2024, Vol. 92 Issue 4, p1323-1337. 15p.
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  Data: <searchLink fieldCode="DE" term="%22Proton+magnetic+resonance+spectroscopy%22">Proton magnetic resonance spectroscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Prostate%22">Prostate</searchLink><br /><searchLink fieldCode="DE" term="%22Spectrometry%22">Spectrometry</searchLink><br /><searchLink fieldCode="DE" term="%22Stromal+cells%22">Stromal cells</searchLink><br /><searchLink fieldCode="DE" term="%22Diffusion+coefficients%22">Diffusion coefficients</searchLink><br /><searchLink fieldCode="DE" term="%22Protein+binding%22">Protein binding</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: Prostate tissue has a complex microstructure, mainly composed of epithelial and stromal cells, and of extracellular (acinar‐luminal) spaces. Diffusion‐weighted MR spectroscopy (DW‐MRS) is ideally suited to explore complex microstructure in vivo with metabolites selectively distributed in different subspaces. To date, this technique has been applied to brain and muscle. This study presents the development and pioneering utilization of 1H‐DW‐MRS in the prostate, accompanied by in vitro studies to support interpretations of in vivo findings. Methods: Nine healthy volunteers underwent a prostate MR examination (mean age, 56 years; range, 31–66). Metabolic complexation was studied in vitro using solutions with major compounds found in prostatic fluid of the lumen. DW‐MRS was performed at 3 T with a non–water‐suppressed single‐voxel sequence with metabolite‐cycling to concurrently measure metabolite and water signals. The water signal was used in postprocessing as a reference in a motion‐compensation scheme. The spectra were fitted simultaneously in the spectral and diffusion‐weighting dimensions. Apparent diffusion coefficients (ADCs) were derived by fitting signal decays that were assumed to be mono‐exponential for metabolites and biexponential for water. Results: DW‐MRS of the prostate revealed relatively low ADCs for Cho and Cr compounds, aligning with their intracellular location and higher ADCs for citrate and spermine supporting their luminal origin. In vitro assessments of the ADCs of citrate and spermine demonstrated their complex formation and protein binding. Tissue concentrations of MRS‐detectable metabolites were as expected for the voxel location. Conclusions: This work successfully demonstrates the feasibility of 1H‐DW‐MRS of the prostate and its potential for providing valuable microstructural information. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/mrm.30141
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        Text: English
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        PageCount: 15
        StartPage: 1323
    Subjects:
      – SubjectFull: Proton magnetic resonance spectroscopy
        Type: general
      – SubjectFull: Prostate
        Type: general
      – SubjectFull: Spectrometry
        Type: general
      – SubjectFull: Stromal cells
        Type: general
      – SubjectFull: Diffusion coefficients
        Type: general
      – SubjectFull: Protein binding
        Type: general
    Titles:
      – TitleFull: Diffusion‐weighted MR spectroscopy of the prostate.
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            – D: 01
              M: 10
              Text: Oct2024
              Type: published
              Y: 2024
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