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Recent Advances in the Multicomponent Synthesis of Heterocycles Using 5-Aminotetrazole.

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Title: Recent Advances in the Multicomponent Synthesis of Heterocycles Using 5-Aminotetrazole.
Authors: Javahershenas, Ramin1 (AUTHOR) jshbco@yahoo.com, Mei, Haibo2 (AUTHOR), Koley, Manankar3 (AUTHOR), Soloshonok, Vadim A.4,5 (AUTHOR), Makarem, Ata6 (AUTHOR) ata.makarem@uni-hamburg.de
Source: Synthesis. Aug2024, Vol. 56 Issue 16, p2445-2461. 17p.
Subjects: Heterocyclic compounds synthesis, Heterocyclic compounds, Spiro compounds
Abstract: The unique reactivity and beneficial features of the 5-aminotetrazole synthon (1 H -tetrazol-5-amine) have made it a versatile and effective building block in the synthesis of heterocyclic compounds. In addition, several drugs containing this scaffold with a wide array of biological properties have been already introduced. Heterocyclic structures are the backbone of many biologically active and industrially important compounds. 5-Aminotetrazole is one of the favored synthons used in the preparation of heterocycle-bearing compounds, especially in multicomponent synthesis. This review highlights a comprehensive overview of the emerging applications of 5-aminotetrazole as a key component in the synthesis of heterocyclic frameworks through multicomponent reactions, reported between 2017 and July 2023. 1 Introduction 2 5-Aminotetrazole 3 Tetrazolopyrimidine Compounds 4 Spiro Compounds 5 Miscellaneous 6 Conclusion [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
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Abstract:The unique reactivity and beneficial features of the 5-aminotetrazole synthon (1 H -tetrazol-5-amine) have made it a versatile and effective building block in the synthesis of heterocyclic compounds. In addition, several drugs containing this scaffold with a wide array of biological properties have been already introduced. Heterocyclic structures are the backbone of many biologically active and industrially important compounds. 5-Aminotetrazole is one of the favored synthons used in the preparation of heterocycle-bearing compounds, especially in multicomponent synthesis. This review highlights a comprehensive overview of the emerging applications of 5-aminotetrazole as a key component in the synthesis of heterocyclic frameworks through multicomponent reactions, reported between 2017 and July 2023. 1 Introduction 2 5-Aminotetrazole 3 Tetrazolopyrimidine Compounds 4 Spiro Compounds 5 Miscellaneous 6 Conclusion [ABSTRACT FROM AUTHOR]
ISSN:00397881
DOI:10.1055/s-0042-1751526