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Safety and efficacy of lasers compared to cold knife in direct visual internal urethrotomy: a systematic review and Meta-analysis.

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Title: Safety and efficacy of lasers compared to cold knife in direct visual internal urethrotomy: a systematic review and Meta-analysis.
Authors: Faizan, Muhammad1 (AUTHOR) muhammadfaizan1131@gmail.com, Mahboob, Eman2 (AUTHOR), Samad, Muhammad Ammar2 (AUTHOR), Fatima, Leenah2 (AUTHOR), Fatima, Ammara2 (AUTHOR), Iqbal, Amna2 (AUTHOR), Rauf, Rafia3 (AUTHOR), Naeem, Mustafa4 (AUTHOR), Shoaib, Umer Bin3 (AUTHOR), Siddiqui, Sarush Ahmed1 (AUTHOR), Imran, Muhammad Hasanain2 (AUTHOR)
Source: Lasers in Medical Science. 8/5/2024, Vol. 39 Issue 1, p1-15. 15p.
Subjects: Carbon dioxide lasers, Excimer lasers, Urethra stricture, Laser therapy, Odds ratio
Abstract: Cold knife urethrotome was introduced in 1971 and it had an 80% success rate. New advancements in this field have shed light on the use of various lasers such as carbon dioxide, Nd: YAG, KTP, Argon, Ho: YAG, and excimer lasers. It has been observed that cold knife urethrotomy has a higher recurrence rate than laser urethrotomy, but the superiority of either treatment modality has not been established yet. Data were thoroughly searched through PubMed, Scopus, and clinicaltrials.gov. We also used clinicaltrials.gov for ongoing and published research. The data was analyzed via R studio version 2023.12.1 (oceanstorm). For dichotomous variables, Odds Ratio (OR) were used to pool data and standardized mean difference was used for continuous variables with 95% confidence intervals (CIs). A total of 14 studies including 1114 participants were included in this meta-analysis. The results of the combined analysis revealed significant relation with a mean difference of 0.99 (95% CI: 0.37; 1.62), and favored laser group. The overall results have shown the laser to have a significant favorable profile demonstrating a recurrence, Odds Ratio of 0.42 (95% CI:0.27;0.65). Patients with laser therapy had a lower risk of complication rate (OR 0.49, 95% Cl: 0.35; 0.67). All the findings obtained by the analysis in this study favour lasers significantly over the cold knife technique especially when mean Qmax, with recurrence and complications taken into account. [ABSTRACT FROM AUTHOR]
Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Safety and efficacy of lasers compared to cold knife in direct visual internal urethrotomy: a systematic review and Meta-analysis.
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  Data: <searchLink fieldCode="AR" term="%22Faizan%2C+Muhammad%22">Faizan, Muhammad</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> muhammadfaizan1131@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Mahboob%2C+Eman%22">Mahboob, Eman</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Samad%2C+Muhammad+Ammar%22">Samad, Muhammad Ammar</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fatima%2C+Leenah%22">Fatima, Leenah</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fatima%2C+Ammara%22">Fatima, Ammara</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Iqbal%2C+Amna%22">Iqbal, Amna</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rauf%2C+Rafia%22">Rauf, Rafia</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Naeem%2C+Mustafa%22">Naeem, Mustafa</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shoaib%2C+Umer+Bin%22">Shoaib, Umer Bin</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Siddiqui%2C+Sarush+Ahmed%22">Siddiqui, Sarush Ahmed</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Imran%2C+Muhammad+Hasanain%22">Imran, Muhammad Hasanain</searchLink><relatesTo>2</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Lasers+in+Medical+Science%22">Lasers in Medical Science</searchLink>. 8/5/2024, Vol. 39 Issue 1, p1-15. 15p.
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  Data: <searchLink fieldCode="DE" term="%22Carbon+dioxide+lasers%22">Carbon dioxide lasers</searchLink><br /><searchLink fieldCode="DE" term="%22Excimer+lasers%22">Excimer lasers</searchLink><br /><searchLink fieldCode="DE" term="%22Urethra+stricture%22">Urethra stricture</searchLink><br /><searchLink fieldCode="DE" term="%22Laser+therapy%22">Laser therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Odds+ratio%22">Odds ratio</searchLink>
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  Data: Cold knife urethrotome was introduced in 1971 and it had an 80% success rate. New advancements in this field have shed light on the use of various lasers such as carbon dioxide, Nd: YAG, KTP, Argon, Ho: YAG, and excimer lasers. It has been observed that cold knife urethrotomy has a higher recurrence rate than laser urethrotomy, but the superiority of either treatment modality has not been established yet. Data were thoroughly searched through PubMed, Scopus, and clinicaltrials.gov. We also used clinicaltrials.gov for ongoing and published research. The data was analyzed via R studio version 2023.12.1 (oceanstorm). For dichotomous variables, Odds Ratio (OR) were used to pool data and standardized mean difference was used for continuous variables with 95% confidence intervals (CIs). A total of 14 studies including 1114 participants were included in this meta-analysis. The results of the combined analysis revealed significant relation with a mean difference of 0.99 (95% CI: 0.37; 1.62), and favored laser group. The overall results have shown the laser to have a significant favorable profile demonstrating a recurrence, Odds Ratio of 0.42 (95% CI:0.27;0.65). Patients with laser therapy had a lower risk of complication rate (OR 0.49, 95% Cl: 0.35; 0.67). All the findings obtained by the analysis in this study favour lasers significantly over the cold knife technique especially when mean Qmax, with recurrence and complications taken into account. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – SubjectFull: Carbon dioxide lasers
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      – SubjectFull: Urethra stricture
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