Analysis of the effect of inert gas on alveolar/venous blood partial pressure by using the operator splitting method.
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| Title: | Analysis of the effect of inert gas on alveolar/venous blood partial pressure by using the operator splitting method. |
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| Authors: | Jyoti1 (AUTHOR), Kwak, Soobin2 (AUTHOR), Ham, Seokjun2 (AUTHOR), Hwang, Youngjin2 (AUTHOR), Kang, Seungyoon2 (AUTHOR), Kim, Junseok2 (AUTHOR) cfdkim@korea.ac.kr |
| Source: | International Journal for Numerical Methods in Biomedical Engineering. Aug2024, Vol. 40 Issue 8, p1-24. 24p. |
| Subjects: | Venous pressure, Finite difference method, Blood gases, Oxygen in the blood, Partial pressure |
| Abstract: | This study aims to investigate how inert gas affects the partial pressure of alveolar and venous blood using a fast and accurate operator splitting method (OSM). Unlike previous complex methods, such as the finite element method (FEM), OSM effectively separates governing equations into smaller sub‐problems, facilitating a better understanding of inert gas transport and exchange between blood capillaries and surrounding tissue. The governing equations were discretized with a fully implicit finite difference method (FDM), which enables the use of larger time steps. The model employed partial differential equations, considering convection‐diffusion in blood and only diffusion in tissue. The study explores the impact of initial arterial pressure, breathing frequency, blood flow velocity, solubility, and diffusivity on the partial pressure of inert gas in blood and tissue. Additionally, the effects of anesthetic inert gas and oxygen on venous blood partial pressure were analyzed. Simulation results demonstrate that the high solubility and diffusivity of anesthetic inert gas lead to its prolonged presence in blood and tissue, resulting in lower partial pressure in venous blood. These findings enhance our understanding of inert gas interaction with alveolar/venous blood, with potential implications for medical diagnostics and therapies. [ABSTRACT FROM AUTHOR] |
| Copyright of International Journal for Numerical Methods in Biomedical Engineering is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Abstract: | This study aims to investigate how inert gas affects the partial pressure of alveolar and venous blood using a fast and accurate operator splitting method (OSM). Unlike previous complex methods, such as the finite element method (FEM), OSM effectively separates governing equations into smaller sub‐problems, facilitating a better understanding of inert gas transport and exchange between blood capillaries and surrounding tissue. The governing equations were discretized with a fully implicit finite difference method (FDM), which enables the use of larger time steps. The model employed partial differential equations, considering convection‐diffusion in blood and only diffusion in tissue. The study explores the impact of initial arterial pressure, breathing frequency, blood flow velocity, solubility, and diffusivity on the partial pressure of inert gas in blood and tissue. Additionally, the effects of anesthetic inert gas and oxygen on venous blood partial pressure were analyzed. Simulation results demonstrate that the high solubility and diffusivity of anesthetic inert gas lead to its prolonged presence in blood and tissue, resulting in lower partial pressure in venous blood. These findings enhance our understanding of inert gas interaction with alveolar/venous blood, with potential implications for medical diagnostics and therapies. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 20407939 |
| DOI: | 10.1002/cnm.3839 |
