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Laser-induced optical breakdown is a prior strategy for acquired melanin-increased disorder in dermal layer.

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Title: Laser-induced optical breakdown is a prior strategy for acquired melanin-increased disorder in dermal layer.
Authors: Lin, Yun-Jhen1 (AUTHOR), Wu, Bing-Qi1 (AUTHOR), Chang, Chang-Cheng2,3 (AUTHOR) changcc1975@gmail.com, Huang, Yung-Hsueh4 (AUTHOR), Wang, Yen-Jen5 (AUTHOR)
Source: Lasers in Medical Science. 8/14/2024, Vol. 39 Issue 1, p1-4. 4p.
Subjects: Multiphoton ionization, Laser therapy, Patient satisfaction, Melanosis, Hyperpigmentation
Abstract: This brief report discusses the challenges in treating dermal melanosis and the limitations of current laser treatments due to inadequate tissue penetration and potential side effects. It introduces laser-induced optical breakdown (LIOB) as a novel therapeutic approach using a picosecond laser with a diffractive lens array (DLA) to target dermal pigmentation effectively. LIOB induces multiphoton ionization, leading to melanin clearance through phagocytosis and apoptotic cell removal, while also promoting dermal remodeling and collagen synthesis. We present a case of successful treatment of dermal pigmentation in a 55-year-old woman using 755 nm-picosecond alexandrite laser therapy, demonstrating significant improvement without recurrence. The findings suggest that LIOB offers a promising solution for acquired dermal hypermelanosis by addressing both diffuse and localized pigmentation effectively, leading to skin rejuvenation with minimal downtime and high patient satisfaction. [ABSTRACT FROM AUTHOR]
Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Laser-induced optical breakdown is a prior strategy for acquired melanin-increased disorder in dermal layer.
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  Data: <searchLink fieldCode="AR" term="%22Lin%2C+Yun-Jhen%22">Lin, Yun-Jhen</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wu%2C+Bing-Qi%22">Wu, Bing-Qi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chang%2C+Chang-Cheng%22">Chang, Chang-Cheng</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<i> changcc1975@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Huang%2C+Yung-Hsueh%22">Huang, Yung-Hsueh</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Yen-Jen%22">Wang, Yen-Jen</searchLink><relatesTo>5</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Lasers+in+Medical+Science%22">Lasers in Medical Science</searchLink>. 8/14/2024, Vol. 39 Issue 1, p1-4. 4p.
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  Data: <searchLink fieldCode="DE" term="%22Multiphoton+ionization%22">Multiphoton ionization</searchLink><br /><searchLink fieldCode="DE" term="%22Laser+therapy%22">Laser therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+satisfaction%22">Patient satisfaction</searchLink><br /><searchLink fieldCode="DE" term="%22Melanosis%22">Melanosis</searchLink><br /><searchLink fieldCode="DE" term="%22Hyperpigmentation%22">Hyperpigmentation</searchLink>
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  Label: Abstract
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  Data: This brief report discusses the challenges in treating dermal melanosis and the limitations of current laser treatments due to inadequate tissue penetration and potential side effects. It introduces laser-induced optical breakdown (LIOB) as a novel therapeutic approach using a picosecond laser with a diffractive lens array (DLA) to target dermal pigmentation effectively. LIOB induces multiphoton ionization, leading to melanin clearance through phagocytosis and apoptotic cell removal, while also promoting dermal remodeling and collagen synthesis. We present a case of successful treatment of dermal pigmentation in a 55-year-old woman using 755 nm-picosecond alexandrite laser therapy, demonstrating significant improvement without recurrence. The findings suggest that LIOB offers a promising solution for acquired dermal hypermelanosis by addressing both diffuse and localized pigmentation effectively, leading to skin rejuvenation with minimal downtime and high patient satisfaction. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1007/s10103-024-04170-4
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      – Code: eng
        Text: English
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      – SubjectFull: Patient satisfaction
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      – SubjectFull: Melanosis
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      – SubjectFull: Hyperpigmentation
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              Text: 8/14/2024
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