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Infrared Spectroscopy Can Differentiate Between Cartilage Injury Models: Implication for Assessment of Cartilage Integrity.

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Title: Infrared Spectroscopy Can Differentiate Between Cartilage Injury Models: Implication for Assessment of Cartilage Integrity.
Authors: Shahini, Fatemeh1,2 (AUTHOR) fatemeh.shahini@uef.fi, Oskouei, Soroush1 (AUTHOR), Nippolainen, Ervin1 (AUTHOR), Mohammadi, Ali1 (AUTHOR), Sarin, Jaakko K.1,3 (AUTHOR), Moller, Nikae C. R. te4 (AUTHOR), Brommer, Harold4 (AUTHOR), Shaikh, Rubina5 (AUTHOR), Korhonen, Rami K.1 (AUTHOR), van Weeren, P. René4,6 (AUTHOR), Töyräs, Juha1,7,8 (AUTHOR), Afara, Isaac O.1,7 (AUTHOR)
Source: Annals of Biomedical Engineering. Sep2024, Vol. 52 Issue 9, p2521-2533. 13p.
Subjects: Machine learning, Mid-infrared spectroscopy, Wrist joint, Articular cartilage, Infrared spectroscopy, Carpal bones
Abstract: In order to improve the ability of clinical diagnosis to differentiate articular cartilage (AC) injury of different origins, this study explores the sensitivity of mid-infrared (MIR) spectroscopy for detecting structural, compositional, and functional changes in AC resulting from two injury types. Three grooves (two in parallel in the palmar-dorsal direction and one in the mediolateral direction) were made via arthrotomy in the AC of the radial facet of the third carpal bone (middle carpal joint) and of the intermediate carpal bone (the radiocarpal joint) of nine healthy adult female Shetland ponies (age = 6.8 ± 2.6 years; range 4–13 years) using blunt and sharp tools. The defects were randomly assigned to each of the two joints. Ponies underwent a 3-week box rest followed by 8 weeks of treadmill training and 26 weeks of free pasture exercise before being euthanized for osteochondral sample collection. The osteochondral samples underwent biomechanical indentation testing, followed by MIR spectroscopic assessment. Digital densitometry was conducted afterward to estimate the tissue's proteoglycan (PG) content. Subsequently, machine learning models were developed to classify the samples to estimate their biomechanical properties and PG content based on the MIR spectra according to injury type. Results show that MIR is able to discriminate healthy from injured AC (91%) and between injury types (88%). The method can also estimate AC properties with relatively low error (thickness = 12.7% mm, equilibrium modulus = 10.7% MPa, instantaneous modulus = 11.8% MPa). These findings demonstrate the potential of MIR spectroscopy as a tool for assessment of AC integrity changes that result from injury. [ABSTRACT FROM AUTHOR]
Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Infrared Spectroscopy Can Differentiate Between Cartilage Injury Models: Implication for Assessment of Cartilage Integrity.
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  Data: <searchLink fieldCode="AR" term="%22Shahini%2C+Fatemeh%22">Shahini, Fatemeh</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> fatemeh.shahini@uef.fi</i><br /><searchLink fieldCode="AR" term="%22Oskouei%2C+Soroush%22">Oskouei, Soroush</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nippolainen%2C+Ervin%22">Nippolainen, Ervin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mohammadi%2C+Ali%22">Mohammadi, Ali</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sarin%2C+Jaakko+K%2E%22">Sarin, Jaakko K.</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Moller%2C+Nikae+C%2E+R%2E+te%22">Moller, Nikae C. R. te</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Brommer%2C+Harold%22">Brommer, Harold</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shaikh%2C+Rubina%22">Shaikh, Rubina</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Korhonen%2C+Rami+K%2E%22">Korhonen, Rami K.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22van+Weeren%2C+P%2E+René%22">van Weeren, P. René</searchLink><relatesTo>4,6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Töyräs%2C+Juha%22">Töyräs, Juha</searchLink><relatesTo>1,7,8</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Afara%2C+Isaac+O%2E%22">Afara, Isaac O.</searchLink><relatesTo>1,7</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Annals+of+Biomedical+Engineering%22">Annals of Biomedical Engineering</searchLink>. Sep2024, Vol. 52 Issue 9, p2521-2533. 13p.
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: In order to improve the ability of clinical diagnosis to differentiate articular cartilage (AC) injury of different origins, this study explores the sensitivity of mid-infrared (MIR) spectroscopy for detecting structural, compositional, and functional changes in AC resulting from two injury types. Three grooves (two in parallel in the palmar-dorsal direction and one in the mediolateral direction) were made via arthrotomy in the AC of the radial facet of the third carpal bone (middle carpal joint) and of the intermediate carpal bone (the radiocarpal joint) of nine healthy adult female Shetland ponies (age = 6.8 ± 2.6 years; range 4–13 years) using blunt and sharp tools. The defects were randomly assigned to each of the two joints. Ponies underwent a 3-week box rest followed by 8 weeks of treadmill training and 26 weeks of free pasture exercise before being euthanized for osteochondral sample collection. The osteochondral samples underwent biomechanical indentation testing, followed by MIR spectroscopic assessment. Digital densitometry was conducted afterward to estimate the tissue's proteoglycan (PG) content. Subsequently, machine learning models were developed to classify the samples to estimate their biomechanical properties and PG content based on the MIR spectra according to injury type. Results show that MIR is able to discriminate healthy from injured AC (91%) and between injury types (88%). The method can also estimate AC properties with relatively low error (thickness = 12.7% mm, equilibrium modulus = 10.7% MPa, instantaneous modulus = 11.8% MPa). These findings demonstrate the potential of MIR spectroscopy as a tool for assessment of AC integrity changes that result from injury. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10439-024-03540-x
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      – Code: eng
        Text: English
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        PageCount: 13
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      – SubjectFull: Machine learning
        Type: general
      – SubjectFull: Mid-infrared spectroscopy
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      – SubjectFull: Wrist joint
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              Text: Sep2024
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