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Simulation and experimental study on the influence of lamina on nanoneedle penetration into the cell nucleus.

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Title: Simulation and experimental study on the influence of lamina on nanoneedle penetration into the cell nucleus.
Authors: Zou, Jie1 (AUTHOR), Peng, Bei1 (AUTHOR), Fan, Na1 (AUTHOR) na_fan@uestc.edu.cn, Liu, Yang2 (AUTHOR) liuyang_leon@scu.edu.cn
Source: Biomechanics & Modeling in Mechanobiology. Aug2024, Vol. 23 Issue 4, p1241-1262. 22p.
Subjects: Cell nuclei, Nuclear density, Nuclear structure, Penetration mechanics, Finite element method, Nuclear membranes
Abstract: We have developed a finite element model to simulate the penetration of nanoneedles into the cellular nucleus. It is found that the nuclear lamina, the primary supporting structure of the nuclear membrane, plays a crucial role in maintaining the integrity of the nuclear envelope and enhancing stress concentration in the nuclear membrane. Notably, nuclear lamina A exhibits a more pronounced effect compared to nuclear lamina B. Subsequently, we further conducted experiments by controlling the time of osteopontin (OPN) treatment to modify the nuclear lamina density, and the results showed that an increase in nuclear lamina density enhances the probability of nanoneedle penetration into the nuclear membrane. Through employing both simulation and experimental techniques, we have gathered compelling evidence indicating that an augmented density of nuclear lamina A can enhance the penetration of nanoneedles into the nuclear membrane. [ABSTRACT FROM AUTHOR]
Copyright of Biomechanics & Modeling in Mechanobiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Simulation and experimental study on the influence of lamina on nanoneedle penetration into the cell nucleus.
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  Data: <searchLink fieldCode="AR" term="%22Zou%2C+Jie%22">Zou, Jie</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Peng%2C+Bei%22">Peng, Bei</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fan%2C+Na%22">Fan, Na</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> na_fan@uestc.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Liu%2C+Yang%22">Liu, Yang</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> liuyang_leon@scu.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Biomechanics+%26+Modeling+in+Mechanobiology%22">Biomechanics & Modeling in Mechanobiology</searchLink>. Aug2024, Vol. 23 Issue 4, p1241-1262. 22p.
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  Data: <searchLink fieldCode="DE" term="%22Cell+nuclei%22">Cell nuclei</searchLink><br /><searchLink fieldCode="DE" term="%22Nuclear+density%22">Nuclear density</searchLink><br /><searchLink fieldCode="DE" term="%22Nuclear+structure%22">Nuclear structure</searchLink><br /><searchLink fieldCode="DE" term="%22Penetration+mechanics%22">Penetration mechanics</searchLink><br /><searchLink fieldCode="DE" term="%22Finite+element+method%22">Finite element method</searchLink><br /><searchLink fieldCode="DE" term="%22Nuclear+membranes%22">Nuclear membranes</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: We have developed a finite element model to simulate the penetration of nanoneedles into the cellular nucleus. It is found that the nuclear lamina, the primary supporting structure of the nuclear membrane, plays a crucial role in maintaining the integrity of the nuclear envelope and enhancing stress concentration in the nuclear membrane. Notably, nuclear lamina A exhibits a more pronounced effect compared to nuclear lamina B. Subsequently, we further conducted experiments by controlling the time of osteopontin (OPN) treatment to modify the nuclear lamina density, and the results showed that an increase in nuclear lamina density enhances the probability of nanoneedle penetration into the nuclear membrane. Through employing both simulation and experimental techniques, we have gathered compelling evidence indicating that an augmented density of nuclear lamina A can enhance the penetration of nanoneedles into the nuclear membrane. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Biomechanics & Modeling in Mechanobiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10237-024-01836-4
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      – Code: eng
        Text: English
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        PageCount: 22
        StartPage: 1241
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      – SubjectFull: Cell nuclei
        Type: general
      – SubjectFull: Nuclear density
        Type: general
      – SubjectFull: Nuclear structure
        Type: general
      – SubjectFull: Penetration mechanics
        Type: general
      – SubjectFull: Finite element method
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      – SubjectFull: Nuclear membranes
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      – TitleFull: Simulation and experimental study on the influence of lamina on nanoneedle penetration into the cell nucleus.
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            NameFull: Peng, Bei
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            – D: 01
              M: 08
              Text: Aug2024
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              Y: 2024
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