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Improving MR axon radius estimation in human white matter using spiral acquisition and field monitoring.

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Title: Improving MR axon radius estimation in human white matter using spiral acquisition and field monitoring.
Authors: Veldmann, Marten1 (AUTHOR), Edwards, Luke J.2 (AUTHOR), Pine, Kerrin J.2 (AUTHOR), Ehses, Philipp1 (AUTHOR), Ferreira, Mónica3,4 (AUTHOR), Weiskopf, Nikolaus2,5,6 (AUTHOR), Stoecker, Tony1,7 (AUTHOR) tony.stoecker@dzne.de
Source: Magnetic Resonance in Medicine. Nov2024, Vol. 92 Issue 5, p1898-1912. 15p.
Subjects: Pyramidal tract, Image reconstruction, White matter (Nerve tissue), Axons, Scanning systems
Abstract: Purpose: To compare MR axon radius estimation in human white matter using a multiband spiral sequence combined with field monitoring to the current state‐of‐the‐art echo‐planar imaging (EPI)‐based approach. Methods: A custom multiband spiral sequence was used for diffusion‐weighted imaging at ultra‐high b$$ b $$‐values. Field monitoring and higher order image reconstruction were employed to greatly reduce artifacts in spiral images. Diffusion weighting parameters were chosen to match a state‐of‐the art EPI‐based axon radius mapping protocol. The spiral approach was compared to the EPI approach by comparing the image signal‐to‐noise ratio (SNR) and performing a test–retest study to assess the respective variability and repeatability of axon radius mapping. Effective axon radius estimates were compared over white matter voxels and along the left corticospinal tract. Results: Increased SNR and reduced artifacts in spiral images led to reduced variability in resulting axon radius maps, especially in low‐SNR regions. Test–retest variability was reduced by a factor of approximately 1.5 using the spiral approach. Reduced repeatability due to significant bias was found for some subjects in both spiral and EPI approaches, and attributed to scanner instability, pointing to a previously unknown limitation of the state‐of‐the‐art approach. Conclusion: Combining spiral readouts with field monitoring improved mapping of the effective axon radius compared to the conventional EPI approach. [ABSTRACT FROM AUTHOR]
Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Improving MR axon radius estimation in human white matter using spiral acquisition and field monitoring.
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  Data: <searchLink fieldCode="AR" term="%22Veldmann%2C+Marten%22">Veldmann, Marten</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Edwards%2C+Luke+J%2E%22">Edwards, Luke J.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pine%2C+Kerrin+J%2E%22">Pine, Kerrin J.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ehses%2C+Philipp%22">Ehses, Philipp</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ferreira%2C+Mónica%22">Ferreira, Mónica</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Weiskopf%2C+Nikolaus%22">Weiskopf, Nikolaus</searchLink><relatesTo>2,5,6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stoecker%2C+Tony%22">Stoecker, Tony</searchLink><relatesTo>1,7</relatesTo> (AUTHOR)<i> tony.stoecker@dzne.de</i>
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  Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Nov2024, Vol. 92 Issue 5, p1898-1912. 15p.
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  Data: <searchLink fieldCode="DE" term="%22Pyramidal+tract%22">Pyramidal tract</searchLink><br /><searchLink fieldCode="DE" term="%22Image+reconstruction%22">Image reconstruction</searchLink><br /><searchLink fieldCode="DE" term="%22White+matter+%28Nerve+tissue%29%22">White matter (Nerve tissue)</searchLink><br /><searchLink fieldCode="DE" term="%22Axons%22">Axons</searchLink><br /><searchLink fieldCode="DE" term="%22Scanning+systems%22">Scanning systems</searchLink>
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  Label: Abstract
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  Data: Purpose: To compare MR axon radius estimation in human white matter using a multiband spiral sequence combined with field monitoring to the current state‐of‐the‐art echo‐planar imaging (EPI)‐based approach. Methods: A custom multiband spiral sequence was used for diffusion‐weighted imaging at ultra‐high b$$ b $$‐values. Field monitoring and higher order image reconstruction were employed to greatly reduce artifacts in spiral images. Diffusion weighting parameters were chosen to match a state‐of‐the art EPI‐based axon radius mapping protocol. The spiral approach was compared to the EPI approach by comparing the image signal‐to‐noise ratio (SNR) and performing a test–retest study to assess the respective variability and repeatability of axon radius mapping. Effective axon radius estimates were compared over white matter voxels and along the left corticospinal tract. Results: Increased SNR and reduced artifacts in spiral images led to reduced variability in resulting axon radius maps, especially in low‐SNR regions. Test–retest variability was reduced by a factor of approximately 1.5 using the spiral approach. Reduced repeatability due to significant bias was found for some subjects in both spiral and EPI approaches, and attributed to scanner instability, pointing to a previously unknown limitation of the state‐of‐the‐art approach. Conclusion: Combining spiral readouts with field monitoring improved mapping of the effective axon radius compared to the conventional EPI approach. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/mrm.30180
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      – Code: eng
        Text: English
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        PageCount: 15
        StartPage: 1898
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      – SubjectFull: Pyramidal tract
        Type: general
      – SubjectFull: Image reconstruction
        Type: general
      – SubjectFull: White matter (Nerve tissue)
        Type: general
      – SubjectFull: Axons
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      – SubjectFull: Scanning systems
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      – TitleFull: Improving MR axon radius estimation in human white matter using spiral acquisition and field monitoring.
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            NameFull: Veldmann, Marten
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            NameFull: Edwards, Luke J.
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            NameFull: Pine, Kerrin J.
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            – D: 01
              M: 11
              Text: Nov2024
              Type: published
              Y: 2024
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