Reduced B0/B1+ sensitivity in velocity‐selective inversion arterial spin labeling using adiabatic refocusing pulses.
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| Title: | Reduced B |
|---|---|
| Authors: | Bolar, Divya S.1,2 (AUTHOR) dbolar@ucsd.edu, Barnes, Ryan A.1,2 (AUTHOR), Chen, Conan1,2,3 (AUTHOR), Han, Fei4 (AUTHOR), Pfeuffer, Josef5 (AUTHOR), Liu, Thomas T.1,2,6 (AUTHOR), Wong, Eric C.1,2,6 (AUTHOR) |
| Source: | Magnetic Resonance in Medicine. Nov2024, Vol. 92 Issue 5, p2091-2100. 10p. |
| Subjects: | Spin labels, Perfusion imaging, Functional magnetic resonance imaging, Spatial variation, Heterogeneity |
| Abstract: | Purpose: To mitigate the B0/B1+ sensitivity of velocity‐selective inversion (VSI) pulse trains for velocity‐selective arterial spin labeling (VSASL) by implementing adiabatic refocusing. This approach aims to achieve artifact‐free VSI‐based perfusion imaging through single‐pair label‐control subtractions, reducing the need for the currently required four‐pair dynamic phase‐cycling (DPC) technique when using a velocity‐insensitive control. Methods: We introduce a Fourier‐transform VSI (FT‐VSI) train that incorporates sinc‐modulated hard excitation pulses with MLEV‐8‐modulated adiabatic hyperbolic secant refocusing pairs. We compare performance between this train and the standard composite refocusing train, including with and without DPC, for dual‐module VSI VSASL. We evaluate (1) simulated velocity‐selective profiles and subtraction fidelity across a broad B0/B1+ range, (2) subtraction fidelity in phantoms, and (3) image quality, artifact presence, and gray‐matter perfusion heterogeneity (as measured by the spatial coefficient of variation) in healthy human subjects. Results: Adiabatic refocusing significantly improves FT‐VSI robustness to B0/B1+ inhomogeneity for a single label‐control subtraction. Subtraction fidelity is dramatically improved in both simulation and phantoms compared with composite refocusing without DPC, and is similar compared with DPC methods. In humans, marked artifacts seen with the non‐DPC composite refocusing approach are eliminated, corroborated by significantly reduced gray‐matter heterogeneity (via lower spatial coefficient of variation values). Conclusion: A novel VSASL labeling train using adiabatic refocusing pulses for VSI was found to reduce artifacts related to B0/B1+ inhomogeneity, thereby providing an alternative to DPC and its associated limitations, which include increased vulnerability to physiological noise and motion, reduced functional MRI applicability, and suboptimal data censoring. [ABSTRACT FROM AUTHOR] |
| Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 179169171 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Reduced B<subscript>0</subscript>/B<subscript>1</subscript><superscript>+</superscript> sensitivity in velocity‐selective inversion arterial spin labeling using adiabatic refocusing pulses. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Bolar%2C+Divya+S%2E%22">Bolar, Divya S.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> dbolar@ucsd.edu</i><br /><searchLink fieldCode="AR" term="%22Barnes%2C+Ryan+A%2E%22">Barnes, Ryan A.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Conan%22">Chen, Conan</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Han%2C+Fei%22">Han, Fei</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pfeuffer%2C+Josef%22">Pfeuffer, Josef</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Thomas+T%2E%22">Liu, Thomas T.</searchLink><relatesTo>1,2,6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wong%2C+Eric+C%2E%22">Wong, Eric C.</searchLink><relatesTo>1,2,6</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Nov2024, Vol. 92 Issue 5, p2091-2100. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Spin+labels%22">Spin labels</searchLink><br /><searchLink fieldCode="DE" term="%22Perfusion+imaging%22">Perfusion imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+magnetic+resonance+imaging%22">Functional magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Spatial+variation%22">Spatial variation</searchLink><br /><searchLink fieldCode="DE" term="%22Heterogeneity%22">Heterogeneity</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: To mitigate the B0/B1+ sensitivity of velocity‐selective inversion (VSI) pulse trains for velocity‐selective arterial spin labeling (VSASL) by implementing adiabatic refocusing. This approach aims to achieve artifact‐free VSI‐based perfusion imaging through single‐pair label‐control subtractions, reducing the need for the currently required four‐pair dynamic phase‐cycling (DPC) technique when using a velocity‐insensitive control. Methods: We introduce a Fourier‐transform VSI (FT‐VSI) train that incorporates sinc‐modulated hard excitation pulses with MLEV‐8‐modulated adiabatic hyperbolic secant refocusing pairs. We compare performance between this train and the standard composite refocusing train, including with and without DPC, for dual‐module VSI VSASL. We evaluate (1) simulated velocity‐selective profiles and subtraction fidelity across a broad B0/B1+ range, (2) subtraction fidelity in phantoms, and (3) image quality, artifact presence, and gray‐matter perfusion heterogeneity (as measured by the spatial coefficient of variation) in healthy human subjects. Results: Adiabatic refocusing significantly improves FT‐VSI robustness to B0/B1+ inhomogeneity for a single label‐control subtraction. Subtraction fidelity is dramatically improved in both simulation and phantoms compared with composite refocusing without DPC, and is similar compared with DPC methods. In humans, marked artifacts seen with the non‐DPC composite refocusing approach are eliminated, corroborated by significantly reduced gray‐matter heterogeneity (via lower spatial coefficient of variation values). Conclusion: A novel VSASL labeling train using adiabatic refocusing pulses for VSI was found to reduce artifacts related to B0/B1+ inhomogeneity, thereby providing an alternative to DPC and its associated limitations, which include increased vulnerability to physiological noise and motion, reduced functional MRI applicability, and suboptimal data censoring. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mrm.30210 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 2091 Subjects: – SubjectFull: Spin labels Type: general – SubjectFull: Perfusion imaging Type: general – SubjectFull: Functional magnetic resonance imaging Type: general – SubjectFull: Spatial variation Type: general – SubjectFull: Heterogeneity Type: general Titles: – TitleFull: Reduced B0/B1+ sensitivity in velocity‐selective inversion arterial spin labeling using adiabatic refocusing pulses. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Bolar, Divya S. – PersonEntity: Name: NameFull: Barnes, Ryan A. – PersonEntity: Name: NameFull: Chen, Conan – PersonEntity: Name: NameFull: Han, Fei – PersonEntity: Name: NameFull: Pfeuffer, Josef – PersonEntity: Name: NameFull: Liu, Thomas T. – PersonEntity: Name: NameFull: Wong, Eric C. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 07403194 Numbering: – Type: volume Value: 92 – Type: issue Value: 5 Titles: – TitleFull: Magnetic Resonance in Medicine Type: main |
| ResultId | 1 |
