View in EDS HTML Full Text PDF Full Text

Assessment of fused deposition modeling (FDM) parameters for fabrication of solid and hollow microneedles using polylactic acid (PLA).

Saved in:
Bibliographic Details
Title: Assessment of fused deposition modeling (FDM) parameters for fabrication of solid and hollow microneedles using polylactic acid (PLA).
Authors: Kouassi, Marie‐Carole1 (AUTHOR), Kallel, Achraf2,3 (AUTHOR) achraf.kallel@irt-systemx.fr, Abdallah, Abir Ben1 (AUTHOR), Nouira, Samia3 (AUTHOR), Ballut, Sébastien1 (AUTHOR), Fitoussi, Joseph3 (AUTHOR), Shirinbayan, Mohammadali3 (AUTHOR)
Source: Polymers for Advanced Technologies. Aug2024, Vol. 35 Issue 8, p1-12. 12p.
Subjects: Fused deposition modeling, Polylactic acid, Chemical processes, Three-dimensional printing, Etching
Abstract: This paper investigates the limits of a Fused Deposition Modeling (FDM) process for the fabrication of solid and hollow microneedle patches. Polylactic acid (PLA), a biodegradable and biocompatible polymer, was used as the printing material. For solid microneedles, the effect of 3D printing parameters on the final quality of printed microneedles was studied. In addition, the microneedles dimensions were varied to obtain microneedles with minimal dimensions and then, to highlight the limitations of the printer used. Solid microneedle with a needle tip diameter of 348 ± 13 μm; a needle base diameter of 744 ± 25 μm and a height of 1488 ± 18 μm as minimal dimensions were successfully printed. The FDM technique, when combined with chemical post‐fabrication etching, effectively improved the size and shape of the printed solid microneedles. However, despite efforts to print hollow microneedles, the FDM process proved insufficient for achieving the desired hollow structures, indicating the need for alternative methods or techniques. Hydrolysis treatment has reduced the dimensions of the printed PLA‐based microneedles. On the other hand, printing tests were carried out to make hollow microneedle patches. The drug reservoir is a part of the microneedle patch, located within the base of the patch. The orientation of the printed object and the addition of supports to the drug reservoir were studied to facilitate the printing of hollow parts. [ABSTRACT FROM AUTHOR]
Copyright of Polymers for Advanced Technologies is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: egs
DbLabel: Engineering Source
An: 179374544
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Assessment of fused deposition modeling (FDM) parameters for fabrication of solid and hollow microneedles using polylactic acid (PLA).
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Kouassi%2C+Marie‐Carole%22">Kouassi, Marie‐Carole</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kallel%2C+Achraf%22">Kallel, Achraf</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<i> achraf.kallel@irt-systemx.fr</i><br /><searchLink fieldCode="AR" term="%22Abdallah%2C+Abir+Ben%22">Abdallah, Abir Ben</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nouira%2C+Samia%22">Nouira, Samia</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ballut%2C+Sébastien%22">Ballut, Sébastien</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fitoussi%2C+Joseph%22">Fitoussi, Joseph</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shirinbayan%2C+Mohammadali%22">Shirinbayan, Mohammadali</searchLink><relatesTo>3</relatesTo> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Polymers+for+Advanced+Technologies%22">Polymers for Advanced Technologies</searchLink>. Aug2024, Vol. 35 Issue 8, p1-12. 12p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Fused+deposition+modeling%22">Fused deposition modeling</searchLink><br /><searchLink fieldCode="DE" term="%22Polylactic+acid%22">Polylactic acid</searchLink><br /><searchLink fieldCode="DE" term="%22Chemical+processes%22">Chemical processes</searchLink><br /><searchLink fieldCode="DE" term="%22Three-dimensional+printing%22">Three-dimensional printing</searchLink><br /><searchLink fieldCode="DE" term="%22Etching%22">Etching</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: This paper investigates the limits of a Fused Deposition Modeling (FDM) process for the fabrication of solid and hollow microneedle patches. Polylactic acid (PLA), a biodegradable and biocompatible polymer, was used as the printing material. For solid microneedles, the effect of 3D printing parameters on the final quality of printed microneedles was studied. In addition, the microneedles dimensions were varied to obtain microneedles with minimal dimensions and then, to highlight the limitations of the printer used. Solid microneedle with a needle tip diameter of 348 ± 13 μm; a needle base diameter of 744 ± 25 μm and a height of 1488 ± 18 μm as minimal dimensions were successfully printed. The FDM technique, when combined with chemical post‐fabrication etching, effectively improved the size and shape of the printed solid microneedles. However, despite efforts to print hollow microneedles, the FDM process proved insufficient for achieving the desired hollow structures, indicating the need for alternative methods or techniques. Hydrolysis treatment has reduced the dimensions of the printed PLA‐based microneedles. On the other hand, printing tests were carried out to make hollow microneedle patches. The drug reservoir is a part of the microneedle patch, located within the base of the patch. The orientation of the printed object and the addition of supports to the drug reservoir were studied to facilitate the printing of hollow parts. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Polymers for Advanced Technologies is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=179374544
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1002/pat.6548
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 12
        StartPage: 1
    Subjects:
      – SubjectFull: Fused deposition modeling
        Type: general
      – SubjectFull: Polylactic acid
        Type: general
      – SubjectFull: Chemical processes
        Type: general
      – SubjectFull: Three-dimensional printing
        Type: general
      – SubjectFull: Etching
        Type: general
    Titles:
      – TitleFull: Assessment of fused deposition modeling (FDM) parameters for fabrication of solid and hollow microneedles using polylactic acid (PLA).
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Kouassi, Marie‐Carole
      – PersonEntity:
          Name:
            NameFull: Kallel, Achraf
      – PersonEntity:
          Name:
            NameFull: Abdallah, Abir Ben
      – PersonEntity:
          Name:
            NameFull: Nouira, Samia
      – PersonEntity:
          Name:
            NameFull: Ballut, Sébastien
      – PersonEntity:
          Name:
            NameFull: Fitoussi, Joseph
      – PersonEntity:
          Name:
            NameFull: Shirinbayan, Mohammadali
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 08
              Text: Aug2024
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-print
              Value: 10427147
          Numbering:
            – Type: volume
              Value: 35
            – Type: issue
              Value: 8
          Titles:
            – TitleFull: Polymers for Advanced Technologies
              Type: main
ResultId 1