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Novel insights into the multifaceted and tissue-specific roles of the endocytic receptor LRP1.

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Title: Novel insights into the multifaceted and tissue-specific roles of the endocytic receptor LRP1.
Authors: Yamamoto, Kazuhiro1 Kazuhiro.yamamoto@liverpool.ac.uk, Scilabra, Simone D.2, Bonelli, Simone2,3, Jensen, Anders1, Scavenius, Carsten4, Enghild, Jan J.4, Strickland, Dudley K.5
Source: Journal of Biological Chemistry. Aug2024, Vol. 300 Issue 8, p1-22. 22p.
Subjects: Bone density, Adaptor proteins, Aortic aneurysms, Cellular signal transduction, Proteomics
Abstract: Receptor-mediated endocytosis provides a mechanism for the selective uptake of specific molecules thereby controlling the composition of the extracellular environment and biological processes. The low-density lipoprotein receptor–related protein 1 (LRP1) is a widely expressed endocytic receptor that regulates cellular events by modulating the levels of numerous extracellular molecules via rapid endocytic removal. LRP1 also participates in signalling pathways through this modulation as well as in the interaction with membrane receptors and cytoplasmic adaptor proteins. LRP1 SNPs are associated with several diseases and conditions such as migraines, aortic aneurysms, cardiopulmonary dysfunction, corneal clouding, and bone dysmorphology and mineral density. Studies using Lrp1 KO mice revealed a critical, nonredundant and tissue-specific role of LRP1 in regulating various physiological events. However, exactly how LRP1 functions to regulate so many distinct and specific processes is still not fully clear. Our recent proteomics studies have identified more than 300 secreted proteins that either directly interact with LRP1 or are modulated by LRP1 in various tissues. This review will highlight the remarkable ability of this receptor to regulate secreted molecules in a tissue-specific manner and discuss potential mechanisms underpinning such specificity. Uncovering the depth of these “hidden” specific interactions modulated by LRP1 will provide novel insights into a dynamic and complex extracellular environment that is involved in diverse biological and pathological processes. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Biological Chemistry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 179389989
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  Label: Title
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  Data: Novel insights into the multifaceted and tissue-specific roles of the endocytic receptor LRP1.
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  Data: <searchLink fieldCode="AR" term="%22Yamamoto%2C+Kazuhiro%22">Yamamoto, Kazuhiro</searchLink><relatesTo>1</relatesTo><i> Kazuhiro.yamamoto@liverpool.ac.uk</i><br /><searchLink fieldCode="AR" term="%22Scilabra%2C+Simone+D%2E%22">Scilabra, Simone D.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Bonelli%2C+Simone%22">Bonelli, Simone</searchLink><relatesTo>2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Jensen%2C+Anders%22">Jensen, Anders</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Scavenius%2C+Carsten%22">Scavenius, Carsten</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Enghild%2C+Jan+J%2E%22">Enghild, Jan J.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Strickland%2C+Dudley+K%2E%22">Strickland, Dudley K.</searchLink><relatesTo>5</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Biological+Chemistry%22">Journal of Biological Chemistry</searchLink>. Aug2024, Vol. 300 Issue 8, p1-22. 22p.
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  Data: <searchLink fieldCode="DE" term="%22Bone+density%22">Bone density</searchLink><br /><searchLink fieldCode="DE" term="%22Adaptor+proteins%22">Adaptor proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Aortic+aneurysms%22">Aortic aneurysms</searchLink><br /><searchLink fieldCode="DE" term="%22Cellular+signal+transduction%22">Cellular signal transduction</searchLink><br /><searchLink fieldCode="DE" term="%22Proteomics%22">Proteomics</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Receptor-mediated endocytosis provides a mechanism for the selective uptake of specific molecules thereby controlling the composition of the extracellular environment and biological processes. The low-density lipoprotein receptor–related protein 1 (LRP1) is a widely expressed endocytic receptor that regulates cellular events by modulating the levels of numerous extracellular molecules via rapid endocytic removal. LRP1 also participates in signalling pathways through this modulation as well as in the interaction with membrane receptors and cytoplasmic adaptor proteins. LRP1 SNPs are associated with several diseases and conditions such as migraines, aortic aneurysms, cardiopulmonary dysfunction, corneal clouding, and bone dysmorphology and mineral density. Studies using Lrp1 KO mice revealed a critical, nonredundant and tissue-specific role of LRP1 in regulating various physiological events. However, exactly how LRP1 functions to regulate so many distinct and specific processes is still not fully clear. Our recent proteomics studies have identified more than 300 secreted proteins that either directly interact with LRP1 or are modulated by LRP1 in various tissues. This review will highlight the remarkable ability of this receptor to regulate secreted molecules in a tissue-specific manner and discuss potential mechanisms underpinning such specificity. Uncovering the depth of these “hidden” specific interactions modulated by LRP1 will provide novel insights into a dynamic and complex extracellular environment that is involved in diverse biological and pathological processes. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Biological Chemistry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.jbc.2024.107521
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      – Code: eng
        Text: English
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        PageCount: 22
        StartPage: 1
    Subjects:
      – SubjectFull: Bone density
        Type: general
      – SubjectFull: Adaptor proteins
        Type: general
      – SubjectFull: Aortic aneurysms
        Type: general
      – SubjectFull: Cellular signal transduction
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      – SubjectFull: Proteomics
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      – TitleFull: Novel insights into the multifaceted and tissue-specific roles of the endocytic receptor LRP1.
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            NameFull: Yamamoto, Kazuhiro
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            NameFull: Scilabra, Simone D.
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            NameFull: Bonelli, Simone
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            NameFull: Jensen, Anders
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            NameFull: Scavenius, Carsten
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            NameFull: Enghild, Jan J.
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              M: 08
              Text: Aug2024
              Type: published
              Y: 2024
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