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Magneto-mechanically derived diffusion processes in ultra-soft biological hydrogels.

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Title: Magneto-mechanically derived diffusion processes in ultra-soft biological hydrogels.
Authors: Gonzalez-Rico, Jorge1 (AUTHOR), Garzon-Hernandez, Sara1 (AUTHOR), Landis, Chad M.2 (AUTHOR), Garcia-Gonzalez, Daniel1 (AUTHOR) danigarc@ing.uc3m.es
Source: Journal of the Mechanics & Physics of Solids. Nov2024, Vol. 192, pN.PAG-N.PAG. 1p.
Subjects: Magnetic particles, Deformations (Mechanics), Magnetic control, Blood plasma, Hydrogels
Abstract: Magneto-active hydrogels (MAHs) consist of a polymeric network doped with magnetic particles that enable the material to mechanically respond to magnetic stimuli. This multifunctionality allows for modulation of mechanical properties in a remote and dynamic manner. These characteristics combined with the biocompatibility of hydrogels, make MAHs excellent for drug delivery and biological scaffolds. In this work, ultra-soft biological MAHs with strong magnetostriction are fabricated from human blood plasma (∼ 20 Pa). The material is experimentally tested using a novel in-house device that allows for a precise control of magnetic actuation conditions, enabling the hydrogel modulation in terms of mechanical deformation and stiffness. We study the impact of magnetic actuation on the solvent expulsion and diffusion dynamics within the polymeric network. To further elucidate the mechanisms driving solvent diffusion processes, a computational framework for modeling the diffusion process of two different species within a magneto-responsive material is proposed. These experimental and computational outcomes open exciting new opportunities for the use of ultra-soft MAHs in bioengineering applications. [ABSTRACT FROM AUTHOR]
Copyright of Journal of the Mechanics & Physics of Solids is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 179502438
AccessLevel: 6
PubType: Periodical
PubTypeId: serialPeriodical
PreciseRelevancyScore: 0
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  Data: Magneto-mechanically derived diffusion processes in ultra-soft biological hydrogels.
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  Data: <searchLink fieldCode="AR" term="%22Gonzalez-Rico%2C+Jorge%22">Gonzalez-Rico, Jorge</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Garzon-Hernandez%2C+Sara%22">Garzon-Hernandez, Sara</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Landis%2C+Chad+M%2E%22">Landis, Chad M.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Garcia-Gonzalez%2C+Daniel%22">Garcia-Gonzalez, Daniel</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> danigarc@ing.uc3m.es</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+the+Mechanics+%26+Physics+of+Solids%22">Journal of the Mechanics & Physics of Solids</searchLink>. Nov2024, Vol. 192, pN.PAG-N.PAG. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Magnetic+particles%22">Magnetic particles</searchLink><br /><searchLink fieldCode="DE" term="%22Deformations+%28Mechanics%29%22">Deformations (Mechanics)</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+control%22">Magnetic control</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+plasma%22">Blood plasma</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrogels%22">Hydrogels</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Magneto-active hydrogels (MAHs) consist of a polymeric network doped with magnetic particles that enable the material to mechanically respond to magnetic stimuli. This multifunctionality allows for modulation of mechanical properties in a remote and dynamic manner. These characteristics combined with the biocompatibility of hydrogels, make MAHs excellent for drug delivery and biological scaffolds. In this work, ultra-soft biological MAHs with strong magnetostriction are fabricated from human blood plasma (∼ 20 Pa). The material is experimentally tested using a novel in-house device that allows for a precise control of magnetic actuation conditions, enabling the hydrogel modulation in terms of mechanical deformation and stiffness. We study the impact of magnetic actuation on the solvent expulsion and diffusion dynamics within the polymeric network. To further elucidate the mechanisms driving solvent diffusion processes, a computational framework for modeling the diffusion process of two different species within a magneto-responsive material is proposed. These experimental and computational outcomes open exciting new opportunities for the use of ultra-soft MAHs in bioengineering applications. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Journal of the Mechanics & Physics of Solids is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.jmps.2024.105791
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Magnetic particles
        Type: general
      – SubjectFull: Deformations (Mechanics)
        Type: general
      – SubjectFull: Magnetic control
        Type: general
      – SubjectFull: Blood plasma
        Type: general
      – SubjectFull: Hydrogels
        Type: general
    Titles:
      – TitleFull: Magneto-mechanically derived diffusion processes in ultra-soft biological hydrogels.
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            NameFull: Gonzalez-Rico, Jorge
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            NameFull: Garzon-Hernandez, Sara
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            NameFull: Landis, Chad M.
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            NameFull: Garcia-Gonzalez, Daniel
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          Dates:
            – D: 01
              M: 11
              Text: Nov2024
              Type: published
              Y: 2024
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              Value: 192
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            – TitleFull: Journal of the Mechanics & Physics of Solids
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