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The Feasibility Study of Dual-Energy CT Virtual Non-Contrast instead of True Non-Contrast in Proton Radiotherapy Dose Calculation.

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Title: The Feasibility Study of Dual-Energy CT Virtual Non-Contrast instead of True Non-Contrast in Proton Radiotherapy Dose Calculation.
Authors: Qu, G.1 (AUTHOR), Zhu, J.2,3 (AUTHOR)
Source: International Journal of Radiation Oncology, Biology, Physics. 2024 Supplement, Vol. 120 Issue 2, pe781-e781. 1p.
Subjects: Vertebrae, Dual energy CT (Tomography), Skull, Protons, Abdomen
Abstract: To study the differences and correlations between true non-contrast (TNC) and virtual non-contrast (VNC) which is reconstructed from dual-energy CT (DECT), and to investigate whether cranial VNC can replace TNC in proton radiotherapy dose calculation. TNC and VNC images of 40 patients were enrolled, including 20 brain, 10 chest and 10 abdomen, to investigate the differences between VNC and TNC. Firstly, home-made software was used to implement layer-by-layer subtraction of the two sets of images according to the Hounsfield Unit (HU) values, which was used to comprehensively observe the differences in HU values between VNC and TNC in 40 patients. The correlation of HU values at sites with significant differences were studied and the correction model for predicting TNC HU values from VNC HU values were established. Proton radiotherapy plans for 20 cranial tumors patients were designed to studied the effect of VNC instead of TNC in proton dose calculations. The differences between VNC and TNC were mainly concentrated in the areas containing bones, especially on skull and vertebrae. The mean HU values difference of the skull and vertebrae were 409.07 ± 53.38 HU, 118.66 ± 20.90HU, respectively. There was a significant association between the HU values of the VNC and TNC in skull and vertebrae in 40 patients (cranial: r = 0.982, vertebral: r = 0.991). The model established in this regard for predicting site-specific TNC HU values based on the VNC HU values was as follow: TNC = 1.859×VNC+33.896 for cranial and TNC = 1.827×VNC+5.491 for vertebral. There was a significant difference in the proton dose distribution on VNC and TNC images. The CTV, the 0.4cm region in front of the CTV and the 0.4cm region behind the CTV mean doses differed by 0.236%,1.803% and 3.561% between the two plans, respectively. The differences between VNC and TNC are mainly concentrated in the areas containing bones, the skull and vertebrae are the most prominent. There is a strong connection between the HU values of the VNC and TNC in skull and vertebrae, and the TNC HU values can be predicted based on VNC HU values in these areas. For cranial patients, VNC is not appropriate to replace TNC for proton radiotherapy dose calculation. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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PubType: Academic Journal
PubTypeId: academicJournal
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  Label: Title
  Group: Ti
  Data: The Feasibility Study of Dual-Energy CT Virtual Non-Contrast instead of True Non-Contrast in Proton Radiotherapy Dose Calculation.
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  Data: <searchLink fieldCode="AR" term="%22Qu%2C+G%2E%22">Qu, G.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhu%2C+J%2E%22">Zhu, J.</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: To study the differences and correlations between true non-contrast (TNC) and virtual non-contrast (VNC) which is reconstructed from dual-energy CT (DECT), and to investigate whether cranial VNC can replace TNC in proton radiotherapy dose calculation. TNC and VNC images of 40 patients were enrolled, including 20 brain, 10 chest and 10 abdomen, to investigate the differences between VNC and TNC. Firstly, home-made software was used to implement layer-by-layer subtraction of the two sets of images according to the Hounsfield Unit (HU) values, which was used to comprehensively observe the differences in HU values between VNC and TNC in 40 patients. The correlation of HU values at sites with significant differences were studied and the correction model for predicting TNC HU values from VNC HU values were established. Proton radiotherapy plans for 20 cranial tumors patients were designed to studied the effect of VNC instead of TNC in proton dose calculations. The differences between VNC and TNC were mainly concentrated in the areas containing bones, especially on skull and vertebrae. The mean HU values difference of the skull and vertebrae were 409.07 ± 53.38 HU, 118.66 ± 20.90HU, respectively. There was a significant association between the HU values of the VNC and TNC in skull and vertebrae in 40 patients (cranial: r = 0.982, vertebral: r = 0.991). The model established in this regard for predicting site-specific TNC HU values based on the VNC HU values was as follow: TNC = 1.859×VNC+33.896 for cranial and TNC = 1.827×VNC+5.491 for vertebral. There was a significant difference in the proton dose distribution on VNC and TNC images. The CTV, the 0.4cm region in front of the CTV and the 0.4cm region behind the CTV mean doses differed by 0.236%,1.803% and 3.561% between the two plans, respectively. The differences between VNC and TNC are mainly concentrated in the areas containing bones, the skull and vertebrae are the most prominent. There is a strong connection between the HU values of the VNC and TNC in skull and vertebrae, and the TNC HU values can be predicted based on VNC HU values in these areas. For cranial patients, VNC is not appropriate to replace TNC for proton radiotherapy dose calculation. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.ijrobp.2024.07.1717
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      – Code: eng
        Text: English
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        StartPage: e781
    Subjects:
      – SubjectFull: Vertebrae
        Type: general
      – SubjectFull: Dual energy CT (Tomography)
        Type: general
      – SubjectFull: Skull
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      – SubjectFull: Protons
        Type: general
      – SubjectFull: Abdomen
        Type: general
    Titles:
      – TitleFull: The Feasibility Study of Dual-Energy CT Virtual Non-Contrast instead of True Non-Contrast in Proton Radiotherapy Dose Calculation.
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              Text: 2024 Supplement
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