Photobiomodulation using red and infrared spectrum light emitting-diode (LED) for the healing of diabetic foot ulcers: a controlled randomized clinical trial.
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| Title: | Photobiomodulation using red and infrared spectrum light emitting-diode (LED) for the healing of diabetic foot ulcers: a controlled randomized clinical trial. |
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| Authors: | Borges, Nathalia Cristina de Souza1 (AUTHOR), Soares, Luíza Rocha2 (AUTHOR), Perissini, Mário Machado2 (AUTHOR), Carvalho, Marcela Silva2 (AUTHOR), Guirro, Elaine Caldeira de Oliveira1,2 (AUTHOR), Freitas, Maria Cristina Foss de3 (AUTHOR), Guirro, Rinaldo Roberto de Jesus1,2 (AUTHOR) rguirro@fmrp.usp.br |
| Source: | Lasers in Medical Science. 10/9/2024, Vol. 39 Issue 1, p1-14. 14p. |
| Subjects: | Diabetic foot, End of treatment, Clinical trials, Photobiomodulation therapy, Skin temperature, Foot diseases |
| Abstract: | Assessing the responses to the application of photobiomodulation using red and infrared spectrum light-emitting diodes (LED) on diabetic foot ulcers. Diabetic volunteers, of both genders, aged between 30 and 65 years, with grade I or II ulcers, were randomized into the groups: red LED, infrared LED, LED associated, and control. Home-based interventions took place on a daily basis for 12 weeks. Assessments of sample characterization were performed on day 1 and 90, and the variables wound healing index, mean skin temperature, sensitivity and pain in the wound area were measured at the pre-intervention time on days 1, 30, 60 and 90, with subsequent follow-up 30 days after the end of treatment. For statistical analysis, the software SPSS, version 17.0, intention-to-treat analysis, data normality was tested, and the linear mixed effects model, with a significance level of 5%. Magnitudes of clinical effect by Cohen's d. At the pre vs post intervention time of 90 days, we found a large clinical effect of G-LED V (d=1.7) and G -LED IV (d=1.6) in relation to G-C, where these intervention groups showed a tendency for faster wound healing compared to G-C. We also observed small clinical effect of G-LED IV, which showed greater reduction in the area in relation to G-LED V (d=0.4) and G-LED A (d=0.3). Conclusion: The use of individually applied red and infrared LED phototherapy clinically tended to be more effective for the reduction of diabetic foot ulcer areas, and infrared LED was the most effective. Trial registration: NCT03250533 (clinicaltrials.gov). [ABSTRACT FROM AUTHOR] |
| Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: egs DbLabel: Engineering Source An: 180168194 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Photobiomodulation using red and infrared spectrum light emitting-diode (LED) for the healing of diabetic foot ulcers: a controlled randomized clinical trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Borges%2C+Nathalia+Cristina+de+Souza%22">Borges, Nathalia Cristina de Souza</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Soares%2C+Luíza+Rocha%22">Soares, Luíza Rocha</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Perissini%2C+Mário+Machado%22">Perissini, Mário Machado</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Carvalho%2C+Marcela+Silva%22">Carvalho, Marcela Silva</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guirro%2C+Elaine+Caldeira+de+Oliveira%22">Guirro, Elaine Caldeira de Oliveira</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Freitas%2C+Maria+Cristina+Foss+de%22">Freitas, Maria Cristina Foss de</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guirro%2C+Rinaldo+Roberto+de+Jesus%22">Guirro, Rinaldo Roberto de Jesus</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> rguirro@fmrp.usp.br</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Lasers+in+Medical+Science%22">Lasers in Medical Science</searchLink>. 10/9/2024, Vol. 39 Issue 1, p1-14. 14p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Diabetic+foot%22">Diabetic foot</searchLink><br /><searchLink fieldCode="DE" term="%22End+of+treatment%22">End of treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+trials%22">Clinical trials</searchLink><br /><searchLink fieldCode="DE" term="%22Photobiomodulation+therapy%22">Photobiomodulation therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Skin+temperature%22">Skin temperature</searchLink><br /><searchLink fieldCode="DE" term="%22Foot+diseases%22">Foot diseases</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Assessing the responses to the application of photobiomodulation using red and infrared spectrum light-emitting diodes (LED) on diabetic foot ulcers. Diabetic volunteers, of both genders, aged between 30 and 65 years, with grade I or II ulcers, were randomized into the groups: red LED, infrared LED, LED associated, and control. Home-based interventions took place on a daily basis for 12 weeks. Assessments of sample characterization were performed on day 1 and 90, and the variables wound healing index, mean skin temperature, sensitivity and pain in the wound area were measured at the pre-intervention time on days 1, 30, 60 and 90, with subsequent follow-up 30 days after the end of treatment. For statistical analysis, the software SPSS, version 17.0, intention-to-treat analysis, data normality was tested, and the linear mixed effects model, with a significance level of 5%. Magnitudes of clinical effect by Cohen's d. At the pre vs post intervention time of 90 days, we found a large clinical effect of G-LED V (d=1.7) and G -LED IV (d=1.6) in relation to G-C, where these intervention groups showed a tendency for faster wound healing compared to G-C. We also observed small clinical effect of G-LED IV, which showed greater reduction in the area in relation to G-LED V (d=0.4) and G-LED A (d=0.3). Conclusion: The use of individually applied red and infrared LED phototherapy clinically tended to be more effective for the reduction of diabetic foot ulcer areas, and infrared LED was the most effective. Trial registration: NCT03250533 (clinicaltrials.gov). [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=180168194 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10103-024-04199-5 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 14 StartPage: 1 Subjects: – SubjectFull: Diabetic foot Type: general – SubjectFull: End of treatment Type: general – SubjectFull: Clinical trials Type: general – SubjectFull: Photobiomodulation therapy Type: general – SubjectFull: Skin temperature Type: general – SubjectFull: Foot diseases Type: general Titles: – TitleFull: Photobiomodulation using red and infrared spectrum light emitting-diode (LED) for the healing of diabetic foot ulcers: a controlled randomized clinical trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Borges, Nathalia Cristina de Souza – PersonEntity: Name: NameFull: Soares, Luíza Rocha – PersonEntity: Name: NameFull: Perissini, Mário Machado – PersonEntity: Name: NameFull: Carvalho, Marcela Silva – PersonEntity: Name: NameFull: Guirro, Elaine Caldeira de Oliveira – PersonEntity: Name: NameFull: Freitas, Maria Cristina Foss de – PersonEntity: Name: NameFull: Guirro, Rinaldo Roberto de Jesus IsPartOfRelationships: – BibEntity: Dates: – D: 09 M: 10 Text: 10/9/2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 02688921 Numbering: – Type: volume Value: 39 – Type: issue Value: 1 Titles: – TitleFull: Lasers in Medical Science Type: main |
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