View in EDS HTML Full Text PDF Full Text

Design and characterization of a hybrid PET detector with DOI capability.

Saved in:
Bibliographic Details
Title: Design and characterization of a hybrid PET detector with DOI capability.
Authors: He, Wen1,2 (AUTHOR) hewen@szbl.ac.cn, Zhao, Yangyang1 (AUTHOR), Zeng, Honghao1,3 (AUTHOR), Huang, Wenjie1 (AUTHOR), Yang, Hang1 (AUTHOR), Zhao, Xin1 (AUTHOR), Wang, Qiang4 (AUTHOR), Wang, Lu4 (AUTHOR), Niu, Ming1 (AUTHOR), Zhang, Lei2,5 (AUTHOR), Ren, Qiushi1,2 (AUTHOR), Gu, Zheng1,2 (AUTHOR) guzheng@szbl.ac.cn
Source: Medical Physics. Oct2024, Vol. 51 Issue 10, p7140-7152. 13p.
Subjects: Photon detectors, Timestamps, Spatial resolution, Detectors, Scanning systems, Positron emission tomography
Abstract: Background: Monolithic or semi‐monolithic detectors are attractive for positron emission tomography (PET) scanners with depth‐of‐interaction (DOI) capability. However, they often require complicated calibrations to determine the interaction positions of gamma photons. Purpose: We introduce a novel hybrid detector design that combines pixelated and semi‐monolithic elements to achieve DOI capability while simplifying the calibrations for positioning. Methods: A prototype detector with eight hybrid lutetium–yttrium oxyorthosilicate (LYSO) layers having dimensions of 25.8 × 12.9 × 15 mm3 was constructed. The energy‐weighted and energy‐squared weighted averages were used for estimating the x‐ (pixelated direction) and y‐positions (non‐pixelated direction). Pseudo‐pixels were defined as discrete areas on the flood image based on the crystal look‐up table (LUT). The intrinsic spatial resolutions in the pixelated and non‐pixelated directions were measured. The ratio of the maximum to the sum of the multipixel photon counter (MPPC) signals was used to estimate the DOI positions. The coincidence timing resolution (CTR) was measured using the average and energy‐weighted average of the earliest n time stamps. Two energy windows of 250–700 and 400–600 keV were applied for the measurements. Results: The pattern of the flood images showed discrete event clusters, demonstrating that simple calibrations for determining the x‐ and y‐positions of events could be achieved. Under 400–600 keV energy window, the average intrinsic spatial resolutions were 1.15 and 1.34 mm for the pixelated and non‐pixelated directions; the average DOI resolution of the second row of pseudo‐pixels was 5.1 mm in full width at half maximum (FWHM); when using the energy‐weighted average of the earliest four‐time stamps, the best CTR of 350 ps was achieved. Applying a broader energy window of 250–700 keV only slightly degrades the DOI resolution while maintaining the intrinsic resolution; the best CTR degrades to 410 ps. Conclusions: The proposed hybrid detector concept was verified, and a prototype detector showed high performance for 3D positioning and timing resolution. The novel detector concept shows promise for preclinical and clinical PET scanners with DOI capability. [ABSTRACT FROM AUTHOR]
Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: egs
DbLabel: Engineering Source
An: 180293797
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Design and characterization of a hybrid PET detector with DOI capability.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22He%2C+Wen%22">He, Wen</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> hewen@szbl.ac.cn</i><br /><searchLink fieldCode="AR" term="%22Zhao%2C+Yangyang%22">Zhao, Yangyang</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zeng%2C+Honghao%22">Zeng, Honghao</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huang%2C+Wenjie%22">Huang, Wenjie</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Hang%22">Yang, Hang</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhao%2C+Xin%22">Zhao, Xin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Qiang%22">Wang, Qiang</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Lu%22">Wang, Lu</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Niu%2C+Ming%22">Niu, Ming</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Lei%22">Zhang, Lei</searchLink><relatesTo>2,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ren%2C+Qiushi%22">Ren, Qiushi</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gu%2C+Zheng%22">Gu, Zheng</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> guzheng@szbl.ac.cn</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Medical+Physics%22">Medical Physics</searchLink>. Oct2024, Vol. 51 Issue 10, p7140-7152. 13p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Photon+detectors%22">Photon detectors</searchLink><br /><searchLink fieldCode="DE" term="%22Timestamps%22">Timestamps</searchLink><br /><searchLink fieldCode="DE" term="%22Spatial+resolution%22">Spatial resolution</searchLink><br /><searchLink fieldCode="DE" term="%22Detectors%22">Detectors</searchLink><br /><searchLink fieldCode="DE" term="%22Scanning+systems%22">Scanning systems</searchLink><br /><searchLink fieldCode="DE" term="%22Positron+emission+tomography%22">Positron emission tomography</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Monolithic or semi‐monolithic detectors are attractive for positron emission tomography (PET) scanners with depth‐of‐interaction (DOI) capability. However, they often require complicated calibrations to determine the interaction positions of gamma photons. Purpose: We introduce a novel hybrid detector design that combines pixelated and semi‐monolithic elements to achieve DOI capability while simplifying the calibrations for positioning. Methods: A prototype detector with eight hybrid lutetium–yttrium oxyorthosilicate (LYSO) layers having dimensions of 25.8 × 12.9 × 15 mm3 was constructed. The energy‐weighted and energy‐squared weighted averages were used for estimating the x‐ (pixelated direction) and y‐positions (non‐pixelated direction). Pseudo‐pixels were defined as discrete areas on the flood image based on the crystal look‐up table (LUT). The intrinsic spatial resolutions in the pixelated and non‐pixelated directions were measured. The ratio of the maximum to the sum of the multipixel photon counter (MPPC) signals was used to estimate the DOI positions. The coincidence timing resolution (CTR) was measured using the average and energy‐weighted average of the earliest n time stamps. Two energy windows of 250–700 and 400–600 keV were applied for the measurements. Results: The pattern of the flood images showed discrete event clusters, demonstrating that simple calibrations for determining the x‐ and y‐positions of events could be achieved. Under 400–600 keV energy window, the average intrinsic spatial resolutions were 1.15 and 1.34 mm for the pixelated and non‐pixelated directions; the average DOI resolution of the second row of pseudo‐pixels was 5.1 mm in full width at half maximum (FWHM); when using the energy‐weighted average of the earliest four‐time stamps, the best CTR of 350 ps was achieved. Applying a broader energy window of 250–700 keV only slightly degrades the DOI resolution while maintaining the intrinsic resolution; the best CTR degrades to 410 ps. Conclusions: The proposed hybrid detector concept was verified, and a prototype detector showed high performance for 3D positioning and timing resolution. The novel detector concept shows promise for preclinical and clinical PET scanners with DOI capability. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=180293797
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1002/mp.17313
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 13
        StartPage: 7140
    Subjects:
      – SubjectFull: Photon detectors
        Type: general
      – SubjectFull: Timestamps
        Type: general
      – SubjectFull: Spatial resolution
        Type: general
      – SubjectFull: Detectors
        Type: general
      – SubjectFull: Scanning systems
        Type: general
      – SubjectFull: Positron emission tomography
        Type: general
    Titles:
      – TitleFull: Design and characterization of a hybrid PET detector with DOI capability.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: He, Wen
      – PersonEntity:
          Name:
            NameFull: Zhao, Yangyang
      – PersonEntity:
          Name:
            NameFull: Zeng, Honghao
      – PersonEntity:
          Name:
            NameFull: Huang, Wenjie
      – PersonEntity:
          Name:
            NameFull: Yang, Hang
      – PersonEntity:
          Name:
            NameFull: Zhao, Xin
      – PersonEntity:
          Name:
            NameFull: Wang, Qiang
      – PersonEntity:
          Name:
            NameFull: Wang, Lu
      – PersonEntity:
          Name:
            NameFull: Niu, Ming
      – PersonEntity:
          Name:
            NameFull: Zhang, Lei
      – PersonEntity:
          Name:
            NameFull: Ren, Qiushi
      – PersonEntity:
          Name:
            NameFull: Gu, Zheng
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 10
              Text: Oct2024
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-print
              Value: 00942405
          Numbering:
            – Type: volume
              Value: 51
            – Type: issue
              Value: 10
          Titles:
            – TitleFull: Medical Physics
              Type: main
ResultId 1