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Three‐dimensional radial echo‐planar spectroscopic imaging for hyperpolarized 13C MRSI in vivo.

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Title: Three‐dimensional radial echo‐planar spectroscopic imaging for hyperpolarized 13C MRSI in vivo.
Authors: Awenius, Marcel1,2,3 (AUTHOR), Abeln, Helen1,3,4 (AUTHOR), Müller, Melanie1 (AUTHOR), Franke, Vanessa L.1 (AUTHOR), Rincon, Gino1,2,5 (AUTHOR), Glowa, Christin6,7,8 (AUTHOR), Schmitt, Michaela6,8,9 (AUTHOR), Bangert, Renate1 (AUTHOR), Ludwig, Dominik1 (AUTHOR), Schmidt, Andreas B.10,11 (AUTHOR), Kuder, Tristan A.1 (AUTHOR), Ladd, Mark E.1,2,12 (AUTHOR), Bachert, Peter1,2 (AUTHOR), Biegger, Philipp1 (AUTHOR), Korzowski, Andreas1,5 (AUTHOR) a.korzowski@dkfz.de
Source: Magnetic Resonance in Medicine. Jan2025, Vol. 93 Issue 1, p31-41. 11p.
Subjects: Polarization (Nuclear physics), Magnetic resonance imaging, Spectroscopic imaging, Resonators, Pyruvates
Abstract: Purpose: To demonstrate the feasibility of 3D echo‐planar spectroscopic imaging (EPSI) technique with rapid volumetric radial k‐space sampling for hyperpolarized (HP) 13C magnetic resonance spectroscopic imaging (MRSI) in vivo. Methods: A radial EPSI (rEPSI) was implemented on a 3 T clinical PET/MR system. To enable volumetric coverage, the sinusoidal shaped readout gradients per k‐t‐spoke were rotated along the three spatial dimensions in a golden‐angle like manner. A distance‐weighted, density‐compensated gridding reconstruction was used, also in cases with undersampling of spokes in k‐space. Measurements without and with HP 13C‐labeled substances were performed in phantoms and rats using a double‐resonant 13C/1H volume resonator with 72 mm inner diameter. Results: Phantom measurements demonstrated the feasibility of the implemented rEPSI sequence, as well as the robustness to undersampling in k‐space up to a factor of 5 without advanced reconstruction techniques. Applied to measurements with HP [1‐13C]pyruvate in a tumor‐bearing rat, we obtained well‐resolved MRSI datasets with a large matrix size of 123 voxels covering the whole imaging FOV of (180 mm)3 within 6.3 s, enabling to observe metabolism in dynamic acquisitions. Conclusion: After further optimization, the proposed rEPSI method may be useful in applications of HP 13C‐tracers where unknown or varying metabolite resonances are expected, and the acquisition of dynamic, volumetric MRSI datasets with an adequate temporal resolution is a challenge. [ABSTRACT FROM AUTHOR]
Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Three‐dimensional radial echo‐planar spectroscopic imaging for hyperpolarized <superscript>13</superscript>C MRSI in vivo.
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  Data: <searchLink fieldCode="AR" term="%22Awenius%2C+Marcel%22">Awenius, Marcel</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Abeln%2C+Helen%22">Abeln, Helen</searchLink><relatesTo>1,3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Müller%2C+Melanie%22">Müller, Melanie</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Franke%2C+Vanessa+L%2E%22">Franke, Vanessa L.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rincon%2C+Gino%22">Rincon, Gino</searchLink><relatesTo>1,2,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Glowa%2C+Christin%22">Glowa, Christin</searchLink><relatesTo>6,7,8</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schmitt%2C+Michaela%22">Schmitt, Michaela</searchLink><relatesTo>6,8,9</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bangert%2C+Renate%22">Bangert, Renate</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ludwig%2C+Dominik%22">Ludwig, Dominik</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schmidt%2C+Andreas+B%2E%22">Schmidt, Andreas B.</searchLink><relatesTo>10,11</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kuder%2C+Tristan+A%2E%22">Kuder, Tristan A.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ladd%2C+Mark+E%2E%22">Ladd, Mark E.</searchLink><relatesTo>1,2,12</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bachert%2C+Peter%22">Bachert, Peter</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Biegger%2C+Philipp%22">Biegger, Philipp</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Korzowski%2C+Andreas%22">Korzowski, Andreas</searchLink><relatesTo>1,5</relatesTo> (AUTHOR)<i> a.korzowski@dkfz.de</i>
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  Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Jan2025, Vol. 93 Issue 1, p31-41. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Polarization+%28Nuclear+physics%29%22">Polarization (Nuclear physics)</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Spectroscopic+imaging%22">Spectroscopic imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Resonators%22">Resonators</searchLink><br /><searchLink fieldCode="DE" term="%22Pyruvates%22">Pyruvates</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: To demonstrate the feasibility of 3D echo‐planar spectroscopic imaging (EPSI) technique with rapid volumetric radial k‐space sampling for hyperpolarized (HP) 13C magnetic resonance spectroscopic imaging (MRSI) in vivo. Methods: A radial EPSI (rEPSI) was implemented on a 3 T clinical PET/MR system. To enable volumetric coverage, the sinusoidal shaped readout gradients per k‐t‐spoke were rotated along the three spatial dimensions in a golden‐angle like manner. A distance‐weighted, density‐compensated gridding reconstruction was used, also in cases with undersampling of spokes in k‐space. Measurements without and with HP 13C‐labeled substances were performed in phantoms and rats using a double‐resonant 13C/1H volume resonator with 72 mm inner diameter. Results: Phantom measurements demonstrated the feasibility of the implemented rEPSI sequence, as well as the robustness to undersampling in k‐space up to a factor of 5 without advanced reconstruction techniques. Applied to measurements with HP [1‐13C]pyruvate in a tumor‐bearing rat, we obtained well‐resolved MRSI datasets with a large matrix size of 123 voxels covering the whole imaging FOV of (180 mm)3 within 6.3 s, enabling to observe metabolism in dynamic acquisitions. Conclusion: After further optimization, the proposed rEPSI method may be useful in applications of HP 13C‐tracers where unknown or varying metabolite resonances are expected, and the acquisition of dynamic, volumetric MRSI datasets with an adequate temporal resolution is a challenge. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/mrm.30258
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        Text: English
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      – SubjectFull: Magnetic resonance imaging
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