Co-Assembled Nanosystems Exhibiting Intrinsic Fluorescence by Complexation of Amino Terpolymer and Its Quaternized Analog with Aggregation-Induced Emission (AIE) Dye.
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| Title: | Co-Assembled Nanosystems Exhibiting Intrinsic Fluorescence by Complexation of Amino Terpolymer and Its Quaternized Analog with Aggregation-Induced Emission (AIE) Dye. |
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| Authors: | Pantelaiou, Michaila Akathi1 (AUTHOR) akathi39@gmail.com, Vagenas, Dimitrios1 (AUTHOR) dimitrisv98@gmail.com, Karvelis, Evangelos S.2 (AUTHOR) ch05879@uoi.gr, Rotas, Georgios2 (AUTHOR) rotasgiorgos@uoi.gr, Pispas, Stergios1 (AUTHOR) pispas@eie.gr |
| Source: | Nanomaterials (2079-4991). Oct2024, Vol. 14 Issue 20, p1631. 16p. |
| Subjects: | Methyl methacrylate, Methoxyethanol, Ethylene glycol, Methyl ether, Fluorescence spectroscopy |
| Abstract: | Aggregation-induced emission dyes (AIEs) have gained significant interest due to their unique optical properties. Upon aggregation, AIEs can exhibit remarkable fluorescence enhancement. These systems are ideal candidates for applications in bioimaging, such as image-guided drug delivery or surgery. Encapsulation of AIEs in polymeric nanocarriers can result in biocompatible and efficient nanosystems. Herein, we report the fabrication of novel nanoaggregates formulated by amino terpolymer and tetraphenylethylene (TPE) AIE in aqueous media. Poly(di(ethylene glycol) methyl ether methacrylate-co-2-(dimethylamino)ethylmethacrylate-co-oligoethylene glycol methyl ether methacrylate), P(DEGMA-co-DMAEMA-co-OEGMA) hydrophilic terpolymer was utilized for the complexation of the sodium tetraphenylethylene 4,4′,4″,4‴-tetrasulfonate AIE dye. Fluorescence spectroscopy, physicochemical studies, and self-assembly in aqueous and fetal bovine serum media were carried out. The finely dispersed nanoparticles exhibited enhanced fluorescence compared to the pure dye. To investigate the role of tertiary amino groups in the aggregation phenomenon, the polymer was quaternized, and quaternized polymer nanocarriers were fabricated. The increase in fluorescence intensity indicated stronger interaction between the cationic polymer analog and the dye. A stronger interaction between the nanoparticles and fetal bovine serum was observed in the case of the quaternized polymer. Thus, P(DEGMA-co-DMAEMA-co-OEGMA) formulations are better candidates for bioimaging applications than the quaternized ones, presenting both aggregation-induced emission and less interaction with fetal bovine serum. [ABSTRACT FROM AUTHOR] |
| Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: egs DbLabel: Engineering Source An: 180525296 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Co-Assembled Nanosystems Exhibiting Intrinsic Fluorescence by Complexation of Amino Terpolymer and Its Quaternized Analog with Aggregation-Induced Emission (AIE) Dye. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Pantelaiou%2C+Michaila+Akathi%22">Pantelaiou, Michaila Akathi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> akathi39@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Vagenas%2C+Dimitrios%22">Vagenas, Dimitrios</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> dimitrisv98@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Karvelis%2C+Evangelos+S%2E%22">Karvelis, Evangelos S.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> ch05879@uoi.gr</i><br /><searchLink fieldCode="AR" term="%22Rotas%2C+Georgios%22">Rotas, Georgios</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> rotasgiorgos@uoi.gr</i><br /><searchLink fieldCode="AR" term="%22Pispas%2C+Stergios%22">Pispas, Stergios</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> pispas@eie.gr</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nanomaterials+%282079-4991%29%22">Nanomaterials (2079-4991)</searchLink>. Oct2024, Vol. 14 Issue 20, p1631. 16p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Methyl+methacrylate%22">Methyl methacrylate</searchLink><br /><searchLink fieldCode="DE" term="%22Methoxyethanol%22">Methoxyethanol</searchLink><br /><searchLink fieldCode="DE" term="%22Ethylene+glycol%22">Ethylene glycol</searchLink><br /><searchLink fieldCode="DE" term="%22Methyl+ether%22">Methyl ether</searchLink><br /><searchLink fieldCode="DE" term="%22Fluorescence+spectroscopy%22">Fluorescence spectroscopy</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Aggregation-induced emission dyes (AIEs) have gained significant interest due to their unique optical properties. Upon aggregation, AIEs can exhibit remarkable fluorescence enhancement. These systems are ideal candidates for applications in bioimaging, such as image-guided drug delivery or surgery. Encapsulation of AIEs in polymeric nanocarriers can result in biocompatible and efficient nanosystems. Herein, we report the fabrication of novel nanoaggregates formulated by amino terpolymer and tetraphenylethylene (TPE) AIE in aqueous media. Poly(di(ethylene glycol) methyl ether methacrylate-co-2-(dimethylamino)ethylmethacrylate-co-oligoethylene glycol methyl ether methacrylate), P(DEGMA-co-DMAEMA-co-OEGMA) hydrophilic terpolymer was utilized for the complexation of the sodium tetraphenylethylene 4,4′,4″,4‴-tetrasulfonate AIE dye. Fluorescence spectroscopy, physicochemical studies, and self-assembly in aqueous and fetal bovine serum media were carried out. The finely dispersed nanoparticles exhibited enhanced fluorescence compared to the pure dye. To investigate the role of tertiary amino groups in the aggregation phenomenon, the polymer was quaternized, and quaternized polymer nanocarriers were fabricated. The increase in fluorescence intensity indicated stronger interaction between the cationic polymer analog and the dye. A stronger interaction between the nanoparticles and fetal bovine serum was observed in the case of the quaternized polymer. Thus, P(DEGMA-co-DMAEMA-co-OEGMA) formulations are better candidates for bioimaging applications than the quaternized ones, presenting both aggregation-induced emission and less interaction with fetal bovine serum. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/nano14201631 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 16 StartPage: 1631 Subjects: – SubjectFull: Methyl methacrylate Type: general – SubjectFull: Methoxyethanol Type: general – SubjectFull: Ethylene glycol Type: general – SubjectFull: Methyl ether Type: general – SubjectFull: Fluorescence spectroscopy Type: general Titles: – TitleFull: Co-Assembled Nanosystems Exhibiting Intrinsic Fluorescence by Complexation of Amino Terpolymer and Its Quaternized Analog with Aggregation-Induced Emission (AIE) Dye. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Pantelaiou, Michaila Akathi – PersonEntity: Name: NameFull: Vagenas, Dimitrios – PersonEntity: Name: NameFull: Karvelis, Evangelos S. – PersonEntity: Name: NameFull: Rotas, Georgios – PersonEntity: Name: NameFull: Pispas, Stergios IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 10 Text: Oct2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 20794991 Numbering: – Type: volume Value: 14 – Type: issue Value: 20 Titles: – TitleFull: Nanomaterials (2079-4991) Type: main |
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