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A mathematical model of melatonin synthesis and interactions with the circadian clock.

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Title: A mathematical model of melatonin synthesis and interactions with the circadian clock.
Authors: Best, Janet1 (AUTHOR) best.82@osu.edu, Kim, Ruby2 (AUTHOR), Reed, Michael3 (AUTHOR), Nijhout, H. Frederik4 (AUTHOR)
Source: Mathematical Biosciences. Nov2024, Vol. 377, pN.PAG-N.PAG. 1p.
Subjects: Jet lag, Cerebrospinal fluid, Sleep disorders, Suprachiasmatic nucleus, Melatonin, Serotonin
Abstract: A new mathematical model of melatonin synthesis in pineal cells is created and connected to a slightly modified previously created model of the circadian clock in the suprachiasmatic nucleus (SCN). The SCN influences the production of melatonin by upregulating two key enzymes in the pineal. The melatonin produced enters the blood and the cerebrospinal fluid and thus the SCN, influencing the circadian clock. We show that the model of melatonin synthesis corresponds well with extant experimental data and responds similarly to clinical experiments on bright light in the middle of the night. Melatonin is widely used to treat jet lag and sleep disorders. We show how the feedback from the pineal to the SCN causes phase resetting of the circadian clock. Melatonin doses early in the evening advance the clock and doses late at night delay the clock with a dead zone in between where the phase of the clock does not change. [Display omitted] • New model of the synthesis of melatonin connected bidirectionally to circadian clock. • The model predicts well experimental and clinical data. • Influence of melatonin on Per expression explains shape of phase response curve.. [ABSTRACT FROM AUTHOR]
Copyright of Mathematical Biosciences is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 180585381
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PubTypeId: serialPeriodical
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  Label: Title
  Group: Ti
  Data: A mathematical model of melatonin synthesis and interactions with the circadian clock.
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  Data: <searchLink fieldCode="AR" term="%22Best%2C+Janet%22">Best, Janet</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> best.82@osu.edu</i><br /><searchLink fieldCode="AR" term="%22Kim%2C+Ruby%22">Kim, Ruby</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Reed%2C+Michael%22">Reed, Michael</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nijhout%2C+H%2E+Frederik%22">Nijhout, H. Frederik</searchLink><relatesTo>4</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Mathematical+Biosciences%22">Mathematical Biosciences</searchLink>. Nov2024, Vol. 377, pN.PAG-N.PAG. 1p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Jet+lag%22">Jet lag</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebrospinal+fluid%22">Cerebrospinal fluid</searchLink><br /><searchLink fieldCode="DE" term="%22Sleep+disorders%22">Sleep disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Suprachiasmatic+nucleus%22">Suprachiasmatic nucleus</searchLink><br /><searchLink fieldCode="DE" term="%22Melatonin%22">Melatonin</searchLink><br /><searchLink fieldCode="DE" term="%22Serotonin%22">Serotonin</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: A new mathematical model of melatonin synthesis in pineal cells is created and connected to a slightly modified previously created model of the circadian clock in the suprachiasmatic nucleus (SCN). The SCN influences the production of melatonin by upregulating two key enzymes in the pineal. The melatonin produced enters the blood and the cerebrospinal fluid and thus the SCN, influencing the circadian clock. We show that the model of melatonin synthesis corresponds well with extant experimental data and responds similarly to clinical experiments on bright light in the middle of the night. Melatonin is widely used to treat jet lag and sleep disorders. We show how the feedback from the pineal to the SCN causes phase resetting of the circadian clock. Melatonin doses early in the evening advance the clock and doses late at night delay the clock with a dead zone in between where the phase of the clock does not change. [Display omitted] • New model of the synthesis of melatonin connected bidirectionally to circadian clock. • The model predicts well experimental and clinical data. • Influence of melatonin on Per expression explains shape of phase response curve.. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Mathematical Biosciences is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=180585381
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.mbs.2024.109280
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Jet lag
        Type: general
      – SubjectFull: Cerebrospinal fluid
        Type: general
      – SubjectFull: Sleep disorders
        Type: general
      – SubjectFull: Suprachiasmatic nucleus
        Type: general
      – SubjectFull: Melatonin
        Type: general
      – SubjectFull: Serotonin
        Type: general
    Titles:
      – TitleFull: A mathematical model of melatonin synthesis and interactions with the circadian clock.
        Type: main
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      – PersonEntity:
          Name:
            NameFull: Best, Janet
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            NameFull: Kim, Ruby
      – PersonEntity:
          Name:
            NameFull: Reed, Michael
      – PersonEntity:
          Name:
            NameFull: Nijhout, H. Frederik
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      – BibEntity:
          Dates:
            – D: 01
              M: 11
              Text: Nov2024
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-print
              Value: 00255564
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            – Type: volume
              Value: 377
          Titles:
            – TitleFull: Mathematical Biosciences
              Type: main
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