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Size-dependent translocation and lymphatic transportation of polymeric nanocarriers post intraperitoneal administration.

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Title: Size-dependent translocation and lymphatic transportation of polymeric nanocarriers post intraperitoneal administration.
Authors: Cai, Yifan1 (AUTHOR), Zhang, Zichen1 (AUTHOR), Liu, Chang1 (AUTHOR), Tai, Zongguang2 (AUTHOR), Zhu, Quangang2 (AUTHOR), Qi, Jianping1,2 (AUTHOR), Lu, Yi1,2,3 (AUTHOR), Chen, Zhongjian1,2 (AUTHOR) aajian818@163.com, Wu, Wei1,2,3,4 (AUTHOR) wuwei@shmu.edu.cn, He, Haisheng1 (AUTHOR) he_haisheng@fudan.edu.cn
Source: Journal of Controlled Release. Dec2024, Vol. 376, p553-565. 13p.
Subjects: Lymphatic metastasis, Abdominal diseases, Lymphatic diseases, Therapeutics, Cancer vaccines
Abstract: Intraperitoneal (i.p.) administered nanomedicine has been widely applied in the clinical treatment of intra-abdominal diseases and preclinical pharmacological investigations. However, current understandings about the in vivo fate of i.p.-administered drug remains controversial owing to lack of reliable investigation tools. This work presents a nanoparticle-labeling strategy based on aggregation-caused quenching (ACQ) probes in the second near-infrared (NIR-II) window, which can eliminate the interference of unbound probes and allow for non-invasive tracking of nanoparticles in deep tissues. Our results strongly evidence a size-dependent absorption and biodistribution of the i.p.-administered polymeric nanocarriers (PNs) with particle sizes ranging from 30 to 1000 nm both in vivo and ex vivo , and moreover provide a clear visualization of lymphatic transportation and lymph node retention of integral PNs. Importantly, our findings suggest that small particles (≤30 nm) are favorable in systemic therapies due to their rapid absorption and high concentration (>19 %ID mL−1) in circulation, while large particles (over 1000 nm) are meant for localized treatment of abdominal diseases. Besides, the high retention of 200 nm nanoparticles within lymph nodes indicates their promising role in cancer vaccines and lymphatic diseases including lymph node metastasis. [Display omitted] [ABSTRACT FROM AUTHOR]
Copyright of Journal of Controlled Release is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 181219165
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Label: Title
  Group: Ti
  Data: Size-dependent translocation and lymphatic transportation of polymeric nanocarriers post intraperitoneal administration.
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  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Cai%2C+Yifan%22">Cai, Yifan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Zichen%22">Zhang, Zichen</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Chang%22">Liu, Chang</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tai%2C+Zongguang%22">Tai, Zongguang</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhu%2C+Quangang%22">Zhu, Quangang</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Qi%2C+Jianping%22">Qi, Jianping</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lu%2C+Yi%22">Lu, Yi</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Zhongjian%22">Chen, Zhongjian</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> aajian818@163.com</i><br /><searchLink fieldCode="AR" term="%22Wu%2C+Wei%22">Wu, Wei</searchLink><relatesTo>1,2,3,4</relatesTo> (AUTHOR)<i> wuwei@shmu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22He%2C+Haisheng%22">He, Haisheng</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> he_haisheng@fudan.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Controlled+Release%22">Journal of Controlled Release</searchLink>. Dec2024, Vol. 376, p553-565. 13p.
– Name: Subject
  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22Lymphatic+metastasis%22">Lymphatic metastasis</searchLink><br /><searchLink fieldCode="DE" term="%22Abdominal+diseases%22">Abdominal diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Lymphatic+diseases%22">Lymphatic diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+vaccines%22">Cancer vaccines</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Intraperitoneal (i.p.) administered nanomedicine has been widely applied in the clinical treatment of intra-abdominal diseases and preclinical pharmacological investigations. However, current understandings about the in vivo fate of i.p.-administered drug remains controversial owing to lack of reliable investigation tools. This work presents a nanoparticle-labeling strategy based on aggregation-caused quenching (ACQ) probes in the second near-infrared (NIR-II) window, which can eliminate the interference of unbound probes and allow for non-invasive tracking of nanoparticles in deep tissues. Our results strongly evidence a size-dependent absorption and biodistribution of the i.p.-administered polymeric nanocarriers (PNs) with particle sizes ranging from 30 to 1000 nm both in vivo and ex vivo , and moreover provide a clear visualization of lymphatic transportation and lymph node retention of integral PNs. Importantly, our findings suggest that small particles (≤30 nm) are favorable in systemic therapies due to their rapid absorption and high concentration (>19 %ID mL−1) in circulation, while large particles (over 1000 nm) are meant for localized treatment of abdominal diseases. Besides, the high retention of 200 nm nanoparticles within lymph nodes indicates their promising role in cancer vaccines and lymphatic diseases including lymph node metastasis. [Display omitted] [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Controlled Release is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.jconrel.2024.10.032
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 13
        StartPage: 553
    Subjects:
      – SubjectFull: Lymphatic metastasis
        Type: general
      – SubjectFull: Abdominal diseases
        Type: general
      – SubjectFull: Lymphatic diseases
        Type: general
      – SubjectFull: Therapeutics
        Type: general
      – SubjectFull: Cancer vaccines
        Type: general
    Titles:
      – TitleFull: Size-dependent translocation and lymphatic transportation of polymeric nanocarriers post intraperitoneal administration.
        Type: main
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            NameFull: Cai, Yifan
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            NameFull: Zhang, Zichen
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            NameFull: Liu, Chang
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            NameFull: Tai, Zongguang
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            NameFull: Zhu, Quangang
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            NameFull: Qi, Jianping
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            NameFull: Lu, Yi
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            NameFull: Wu, Wei
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            NameFull: He, Haisheng
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          Dates:
            – D: 01
              M: 12
              Text: Dec2024
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-print
              Value: 01683659
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            – Type: volume
              Value: 376
          Titles:
            – TitleFull: Journal of Controlled Release
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