Biophysical modeling of low‐energy ion irradiations with NanOx.
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| Title: | Biophysical modeling of low‐energy ion irradiations with NanOx. |
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| Authors: | Alcocer‐Ávila, Mario1 (AUTHOR) m.alcocer-avila@ip2i.in2p3.fr, Levrague, Victor2 (AUTHOR), Delorme, Rachel2 (AUTHOR), Testa, Étienne1 (AUTHOR), Beuve, Michaël1 (AUTHOR) michael.beuve@univ-lyon1.fr |
| Source: | Medical Physics. Dec2024, Vol. 51 Issue 12, p9358-9371. 14p. |
| Subjects: | Boron-neutron capture therapy, Radiation dosimetry, Cell nuclei, Cell survival, Ion beams |
| Abstract: | Background: Targeted radiotherapies with low‐energy ions show interesting possibilities for the selective irradiation of tumor cells, a strategy particularly appropriate for the treatment of disseminated cancer. Two promising examples are boron neutron capture therapy (BNCT) and targeted radionuclide therapy with α$\alpha$‐particle emitters (TAT). The successful clinical translation of these radiotherapies requires the implementation of accurate radiation dosimetry approaches able to take into account the impact on treatments of the biological effectiveness of ions and the heterogeneity in the therapeutic agent distribution inside the tumor cells. To this end, biophysical models can be applied to translate the interactions of radiations with matter into biological endpoints, such as cell survival. Purpose: The NanOx model was initially developed for predicting the cell survival fractions resulting from irradiations with the high‐energy ion beams encountered in hadrontherapy. We present in this work a new implementation of the model that extends its application to irradiations with low‐energy ions, as the ones found in TAT and BNCT. Methods: The NanOx model was adapted to consider the energy loss of primary ions within the sensitive volume (i.e., the cell nucleus). Additional assumptions were introduced to simplify the practical implementation of the model and reduce computation time. In particular, for low‐energy ions the narrow‐track approximation allowed to neglect the energy deposited by secondary electrons outside the sensitive volume, increasing significantly the performance of simulations. Calculations were performed to compare the original hadrontherapy implementation of the NanOx model with the present one in terms of the inactivation cross sections of human salivary gland cells as a function of the kinetic energy of incident α$\alpha$‐particles. Results: The predictions of the previous and current versions of NanOx agreed for incident energies higher than 1 MeV/n. For lower energies, the new NanOx implementation predicted a decrease in the inactivation cross sections that depended on the length of the sensitive volume. Conclusions: We reported in this work an extension of the NanOx biophysical model to consider irradiations with low‐energy ions, such as the ones found in TAT and BNCT. The excellent agreement observed at intermediate and high energies between the original hadrontherapy implementation and the present one showed that NanOx offers a consistent, self‐integrated framework for describing the biological effects induced by ion irradiations. Future work will focus on the application of the latest version of NanOx to cases closer to the clinical setting. [ABSTRACT FROM AUTHOR] |
| Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 181778084 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Biophysical modeling of low‐energy ion irradiations with NanOx. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Alcocer‐Ávila%2C+Mario%22">Alcocer‐Ávila, Mario</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> m.alcocer-avila@ip2i.in2p3.fr</i><br /><searchLink fieldCode="AR" term="%22Levrague%2C+Victor%22">Levrague, Victor</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Delorme%2C+Rachel%22">Delorme, Rachel</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Testa%2C+Étienne%22">Testa, Étienne</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Beuve%2C+Michaël%22">Beuve, Michaël</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> michael.beuve@univ-lyon1.fr</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Medical+Physics%22">Medical Physics</searchLink>. Dec2024, Vol. 51 Issue 12, p9358-9371. 14p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Boron-neutron+capture+therapy%22">Boron-neutron capture therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Radiation+dosimetry%22">Radiation dosimetry</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+nuclei%22">Cell nuclei</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+survival%22">Cell survival</searchLink><br /><searchLink fieldCode="DE" term="%22Ion+beams%22">Ion beams</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: Targeted radiotherapies with low‐energy ions show interesting possibilities for the selective irradiation of tumor cells, a strategy particularly appropriate for the treatment of disseminated cancer. Two promising examples are boron neutron capture therapy (BNCT) and targeted radionuclide therapy with α$\alpha$‐particle emitters (TAT). The successful clinical translation of these radiotherapies requires the implementation of accurate radiation dosimetry approaches able to take into account the impact on treatments of the biological effectiveness of ions and the heterogeneity in the therapeutic agent distribution inside the tumor cells. To this end, biophysical models can be applied to translate the interactions of radiations with matter into biological endpoints, such as cell survival. Purpose: The NanOx model was initially developed for predicting the cell survival fractions resulting from irradiations with the high‐energy ion beams encountered in hadrontherapy. We present in this work a new implementation of the model that extends its application to irradiations with low‐energy ions, as the ones found in TAT and BNCT. Methods: The NanOx model was adapted to consider the energy loss of primary ions within the sensitive volume (i.e., the cell nucleus). Additional assumptions were introduced to simplify the practical implementation of the model and reduce computation time. In particular, for low‐energy ions the narrow‐track approximation allowed to neglect the energy deposited by secondary electrons outside the sensitive volume, increasing significantly the performance of simulations. Calculations were performed to compare the original hadrontherapy implementation of the NanOx model with the present one in terms of the inactivation cross sections of human salivary gland cells as a function of the kinetic energy of incident α$\alpha$‐particles. Results: The predictions of the previous and current versions of NanOx agreed for incident energies higher than 1 MeV/n. For lower energies, the new NanOx implementation predicted a decrease in the inactivation cross sections that depended on the length of the sensitive volume. Conclusions: We reported in this work an extension of the NanOx biophysical model to consider irradiations with low‐energy ions, such as the ones found in TAT and BNCT. The excellent agreement observed at intermediate and high energies between the original hadrontherapy implementation and the present one showed that NanOx offers a consistent, self‐integrated framework for describing the biological effects induced by ion irradiations. Future work will focus on the application of the latest version of NanOx to cases closer to the clinical setting. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mp.17407 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 14 StartPage: 9358 Subjects: – SubjectFull: Boron-neutron capture therapy Type: general – SubjectFull: Radiation dosimetry Type: general – SubjectFull: Cell nuclei Type: general – SubjectFull: Cell survival Type: general – SubjectFull: Ion beams Type: general Titles: – TitleFull: Biophysical modeling of low‐energy ion irradiations with NanOx. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Alcocer‐Ávila, Mario – PersonEntity: Name: NameFull: Levrague, Victor – PersonEntity: Name: NameFull: Delorme, Rachel – PersonEntity: Name: NameFull: Testa, Étienne – PersonEntity: Name: NameFull: Beuve, Michaël IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 00942405 Numbering: – Type: volume Value: 51 – Type: issue Value: 12 Titles: – TitleFull: Medical Physics Type: main |
| ResultId | 1 |
