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Apoptotic body based biomimetic hybrid nanovesicles to attenuate cytokine storms for sepsis treatment.

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Title: Apoptotic body based biomimetic hybrid nanovesicles to attenuate cytokine storms for sepsis treatment.
Authors: Lan, Hongbing1,2 (AUTHOR), Zhou, Zhanhao3 (AUTHOR), Hu, Qian2 (AUTHOR), Xie, Qi2 (AUTHOR), Li, Xiaonan2 (AUTHOR), Tian, Tianyi2 (AUTHOR), Wang, Yi2 (AUTHOR), Yang, Conglian2 (AUTHOR), Kong, Li2 (AUTHOR), Fu, Dehao4 (AUTHOR) fudehao@sjtu.edu.cn, Guo, Yuanyuan3,5 (AUTHOR) yuanyuanguo@hust.edu.cn, Zhang, Zhiping2,6 (AUTHOR) zhipingzhang@mail.hust.edu.cn
Source: Journal of Nanobiotechnology. 12/19/2024, p1-19. 19p.
Subjects: Apoptotic bodies, Polymersomes, Medical sciences, Cytokine release syndrome, Drug delivery systems
Abstract: Sepsis is a severe immune response to pathogens that is associated with high mortality rate and a paucity of efficacious treatment options. It is characterized by the hyperactivation of macrophages and the occurrence of cytokine storms. Given the anti-inflammatory properties of M2 macrophages and their derived apoptotic bodies (AB), as well as the specific uptake of these by macrophages, a novel approach was employed to combine AB with artificial liposomes to create apoptotic body based biomimetic hybrid nanovesicles (L-AB). The L-AB effectively inherited "eat me" signaling molecules on the surface of the AB, thereby facilitating their targeted uptake by macrophages in both in vitro and in vivo settings. The administration of L-AB for the delivery of dexamethasone effectively augmented the therapeutic efficacy of the drug, mitigated macrophage hyperactivation and tissue damage in vivo, and consequently enhanced the survival rate of septic mice. Taken together, these findings suggest that the apoptotic body biomimetic nanovesicles may represent a potential drug delivery system capable of specifically targeting macrophages for the treatment of sepsis. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Nanobiotechnology is the property of BioMed Central and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
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PubType: Academic Journal
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  Data: Apoptotic body based biomimetic hybrid nanovesicles to attenuate cytokine storms for sepsis treatment.
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  Data: <searchLink fieldCode="AR" term="%22Lan%2C+Hongbing%22">Lan, Hongbing</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhou%2C+Zhanhao%22">Zhou, Zhanhao</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hu%2C+Qian%22">Hu, Qian</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xie%2C+Qi%22">Xie, Qi</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Xiaonan%22">Li, Xiaonan</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tian%2C+Tianyi%22">Tian, Tianyi</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Yi%22">Wang, Yi</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Conglian%22">Yang, Conglian</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kong%2C+Li%22">Kong, Li</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fu%2C+Dehao%22">Fu, Dehao</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> fudehao@sjtu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Guo%2C+Yuanyuan%22">Guo, Yuanyuan</searchLink><relatesTo>3,5</relatesTo> (AUTHOR)<i> yuanyuanguo@hust.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Zhiping%22">Zhang, Zhiping</searchLink><relatesTo>2,6</relatesTo> (AUTHOR)<i> zhipingzhang@mail.hust.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Nanobiotechnology%22">Journal of Nanobiotechnology</searchLink>. 12/19/2024, p1-19. 19p.
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  Data: Sepsis is a severe immune response to pathogens that is associated with high mortality rate and a paucity of efficacious treatment options. It is characterized by the hyperactivation of macrophages and the occurrence of cytokine storms. Given the anti-inflammatory properties of M2 macrophages and their derived apoptotic bodies (AB), as well as the specific uptake of these by macrophages, a novel approach was employed to combine AB with artificial liposomes to create apoptotic body based biomimetic hybrid nanovesicles (L-AB). The L-AB effectively inherited "eat me" signaling molecules on the surface of the AB, thereby facilitating their targeted uptake by macrophages in both in vitro and in vivo settings. The administration of L-AB for the delivery of dexamethasone effectively augmented the therapeutic efficacy of the drug, mitigated macrophage hyperactivation and tissue damage in vivo, and consequently enhanced the survival rate of septic mice. Taken together, these findings suggest that the apoptotic body biomimetic nanovesicles may represent a potential drug delivery system capable of specifically targeting macrophages for the treatment of sepsis. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Nanobiotechnology is the property of BioMed Central and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=181781033
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        Value: 10.1186/s12951-024-03058-3
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        Text: English
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        PageCount: 19
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    Subjects:
      – SubjectFull: Apoptotic bodies
        Type: general
      – SubjectFull: Polymersomes
        Type: general
      – SubjectFull: Medical sciences
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      – SubjectFull: Cytokine release syndrome
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      – SubjectFull: Drug delivery systems
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      – TitleFull: Apoptotic body based biomimetic hybrid nanovesicles to attenuate cytokine storms for sepsis treatment.
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            NameFull: Lan, Hongbing
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              Text: 12/19/2024
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