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Modulation of the replication of positive-sense RNA viruses by the natural plant metabolite xanthohumol and its derivatives.

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Title: Modulation of the replication of positive-sense RNA viruses by the natural plant metabolite xanthohumol and its derivatives.
Authors: Marongiu, Luigi1,2 (AUTHOR) luigi.marongiu@uni-hohenheim.de, Burkard, Markus1 (AUTHOR), Helling, Thomas1 (AUTHOR), Biendl, Martin3 (AUTHOR), Venturelli, Sascha1,4 (AUTHOR) sascha.venturelli@uni-hohenheim.de
Source: Critical Reviews in Food Science & Nutrition. 2025, Vol. 65 Issue 3, p429-443. 15p.
Subjects: Porcine reproductive & respiratory syndrome, Plant viruses, Sexual cycle, Hepatitis C virus, RNA viruses
Abstract: The COVID-19 pandemic has highlighted the importance of identifying new potent antiviral agents. Nutrients as well as plant-derived substances are promising candidates because they are usually well tolerated by the human body and readily available in nature, and consequently mostly cheap to produce. A variety of antiviral effects have recently been described for the hop chalcone xanthohumol (XN), and to a lesser extent for its derivatives, making these hop compounds particularly attractive for further investigation. Noteworthy, mounting evidence indicated that XN can suppress a wide range of viruses belonging to several virus families, all of which share a common reproductive cycle. As a result, the purpose of this review is to summarize the most recent research on the antiviral properties of XN and its derivatives, with a particular emphasis on the positive-sense RNA viruses human hepatitis C virus (HCV), porcine reproductive and respiratory syndrome virus (PRRSV), and severe acute respiratory syndrome corona virus (SARS-CoV-2). [ABSTRACT FROM AUTHOR]
Copyright of Critical Reviews in Food Science & Nutrition is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
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  Data: Modulation of the replication of positive-sense RNA viruses by the natural plant metabolite xanthohumol and its derivatives.
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  Data: <searchLink fieldCode="AR" term="%22Marongiu%2C+Luigi%22">Marongiu, Luigi</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> luigi.marongiu@uni-hohenheim.de</i><br /><searchLink fieldCode="AR" term="%22Burkard%2C+Markus%22">Burkard, Markus</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Helling%2C+Thomas%22">Helling, Thomas</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Biendl%2C+Martin%22">Biendl, Martin</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Venturelli%2C+Sascha%22">Venturelli, Sascha</searchLink><relatesTo>1,4</relatesTo> (AUTHOR)<i> sascha.venturelli@uni-hohenheim.de</i>
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  Data: <searchLink fieldCode="JN" term="%22Critical+Reviews+in+Food+Science+%26+Nutrition%22">Critical Reviews in Food Science & Nutrition</searchLink>. 2025, Vol. 65 Issue 3, p429-443. 15p.
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  Data: <searchLink fieldCode="DE" term="%22Porcine+reproductive+%26+respiratory+syndrome%22">Porcine reproductive & respiratory syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Plant+viruses%22">Plant viruses</searchLink><br /><searchLink fieldCode="DE" term="%22Sexual+cycle%22">Sexual cycle</searchLink><br /><searchLink fieldCode="DE" term="%22Hepatitis+C+virus%22">Hepatitis C virus</searchLink><br /><searchLink fieldCode="DE" term="%22RNA+viruses%22">RNA viruses</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The COVID-19 pandemic has highlighted the importance of identifying new potent antiviral agents. Nutrients as well as plant-derived substances are promising candidates because they are usually well tolerated by the human body and readily available in nature, and consequently mostly cheap to produce. A variety of antiviral effects have recently been described for the hop chalcone xanthohumol (XN), and to a lesser extent for its derivatives, making these hop compounds particularly attractive for further investigation. Noteworthy, mounting evidence indicated that XN can suppress a wide range of viruses belonging to several virus families, all of which share a common reproductive cycle. As a result, the purpose of this review is to summarize the most recent research on the antiviral properties of XN and its derivatives, with a particular emphasis on the positive-sense RNA viruses human hepatitis C virus (HCV), porcine reproductive and respiratory syndrome virus (PRRSV), and severe acute respiratory syndrome corona virus (SARS-CoV-2). [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Critical Reviews in Food Science & Nutrition is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1080/10408398.2023.2275169
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      – Code: eng
        Text: English
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        PageCount: 15
        StartPage: 429
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      – SubjectFull: Porcine reproductive & respiratory syndrome
        Type: general
      – SubjectFull: Plant viruses
        Type: general
      – SubjectFull: Sexual cycle
        Type: general
      – SubjectFull: Hepatitis C virus
        Type: general
      – SubjectFull: RNA viruses
        Type: general
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      – TitleFull: Modulation of the replication of positive-sense RNA viruses by the natural plant metabolite xanthohumol and its derivatives.
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            NameFull: Helling, Thomas
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            NameFull: Biendl, Martin
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              Text: 2025
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              Y: 2025
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