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Modulation of the replication of positive-sense RNA viruses by the natural plant metabolite xanthohumol and its derivatives.

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Title: Modulation of the replication of positive-sense RNA viruses by the natural plant metabolite xanthohumol and its derivatives.
Authors: Marongiu, Luigi1,2 (AUTHOR) luigi.marongiu@uni-hohenheim.de, Burkard, Markus1 (AUTHOR), Helling, Thomas1 (AUTHOR), Biendl, Martin3 (AUTHOR), Venturelli, Sascha1,4 (AUTHOR) sascha.venturelli@uni-hohenheim.de
Source: Critical Reviews in Food Science & Nutrition. 2025, Vol. 65 Issue 3, p429-443. 15p.
Subjects: Porcine reproductive & respiratory syndrome, Plant viruses, Sexual cycle, Hepatitis C virus, RNA viruses
Abstract: The COVID-19 pandemic has highlighted the importance of identifying new potent antiviral agents. Nutrients as well as plant-derived substances are promising candidates because they are usually well tolerated by the human body and readily available in nature, and consequently mostly cheap to produce. A variety of antiviral effects have recently been described for the hop chalcone xanthohumol (XN), and to a lesser extent for its derivatives, making these hop compounds particularly attractive for further investigation. Noteworthy, mounting evidence indicated that XN can suppress a wide range of viruses belonging to several virus families, all of which share a common reproductive cycle. As a result, the purpose of this review is to summarize the most recent research on the antiviral properties of XN and its derivatives, with a particular emphasis on the positive-sense RNA viruses human hepatitis C virus (HCV), porcine reproductive and respiratory syndrome virus (PRRSV), and severe acute respiratory syndrome corona virus (SARS-CoV-2). [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
Description
Abstract:The COVID-19 pandemic has highlighted the importance of identifying new potent antiviral agents. Nutrients as well as plant-derived substances are promising candidates because they are usually well tolerated by the human body and readily available in nature, and consequently mostly cheap to produce. A variety of antiviral effects have recently been described for the hop chalcone xanthohumol (XN), and to a lesser extent for its derivatives, making these hop compounds particularly attractive for further investigation. Noteworthy, mounting evidence indicated that XN can suppress a wide range of viruses belonging to several virus families, all of which share a common reproductive cycle. As a result, the purpose of this review is to summarize the most recent research on the antiviral properties of XN and its derivatives, with a particular emphasis on the positive-sense RNA viruses human hepatitis C virus (HCV), porcine reproductive and respiratory syndrome virus (PRRSV), and severe acute respiratory syndrome corona virus (SARS-CoV-2). [ABSTRACT FROM AUTHOR]
ISSN:10408398
DOI:10.1080/10408398.2023.2275169