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Magnetically Controlled Transport of Nanoparticles in Solid Tumor Tissues and Porous Media Using a Tumor-on-a-Chip Format.

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Title: Magnetically Controlled Transport of Nanoparticles in Solid Tumor Tissues and Porous Media Using a Tumor-on-a-Chip Format.
Authors: Zimina, Tatiana1 (AUTHOR) tmzimina@gmail.com, Sitkov, Nikita2 (AUTHOR) fedorovvs.biotech@gmail.com, Brusina, Ksenia1 (AUTHOR) kebrusina@gmail.com, Fedorov, Viacheslav2 (AUTHOR) natashashed1@gmail.com, Mikhailova, Natalia2 (AUTHOR) kggareev@yandex.ru, Testov, Dmitriy1 (AUTHOR) dtestov@bk.ru, Gareev, Kamil2 (AUTHOR) neurobaby12@gmail.com, Samochernykh, Konstantin2 (AUTHOR), Combs, Stephanie3 (AUTHOR) stephanie.combs@tum.de, Shevtsov, Maxim2,3 (AUTHOR) sitkov93@yandex.ru
Source: Nanomaterials (2079-4991). Dec2024, Vol. 14 Issue 24, p2030. 18p.
Subjects: Porous materials, Magnetic nanoparticles, Magnetic particles, Drug efficacy, Magnetic fields, Dextran
Abstract: This study addresses issues in developing spatially controlled magnetic fields for particle guidance, synthesizing biocompatible and chemically stable MNPs and enhancing their specificity to pathological cells through chemical modifications, developing personalized adjustments, and highlighting the potential of tumor-on-a-chip systems, which can simulate tissue environments and assess drug efficacy and dosage in a controlled setting. The research focused on two MNP types, uncoated magnetite nanoparticles (mMNPs) and carboxymethyl dextran coated superparamagnetic nanoparticles (CD-SPIONs), and evaluated their transport properties in microfluidic systems and porous media. The original uncoated mMNPs of bimodal size distribution and the narrow size distribution of the fractions (23 nm and 106 nm by radii) were demonstrated to agglomerate in magnetically driven microfluidic flow, forming a stable stationary web consisting of magnetic fibers within 30 min. CD-SPIONs were demonstrated to migrate in agar gel with the mean pore size equal to or slightly higher than the particle size. The migration velocity was inversely proportional to the size of particles. No compression of the gel was observed under the magnetic field gradient of 40 T/m. In the brain tissue, particles of sizes 220, 350, 820 nm were not penetrating the tissue, while the compression of tissue was observed. The particles of 95 nm size penetrated the tissue at the edge of the sample, and no compression was observed. For all particles, movement through capillary vessels was observed. [ABSTRACT FROM AUTHOR]
Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
  Group: Ti
  Data: Magnetically Controlled Transport of Nanoparticles in Solid Tumor Tissues and Porous Media Using a Tumor-on-a-Chip Format.
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  Data: <searchLink fieldCode="AR" term="%22Zimina%2C+Tatiana%22">Zimina, Tatiana</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> tmzimina@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Sitkov%2C+Nikita%22">Sitkov, Nikita</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> fedorovvs.biotech@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Brusina%2C+Ksenia%22">Brusina, Ksenia</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> kebrusina@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Fedorov%2C+Viacheslav%22">Fedorov, Viacheslav</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> natashashed1@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Mikhailova%2C+Natalia%22">Mikhailova, Natalia</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> kggareev@yandex.ru</i><br /><searchLink fieldCode="AR" term="%22Testov%2C+Dmitriy%22">Testov, Dmitriy</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> dtestov@bk.ru</i><br /><searchLink fieldCode="AR" term="%22Gareev%2C+Kamil%22">Gareev, Kamil</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> neurobaby12@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Samochernykh%2C+Konstantin%22">Samochernykh, Konstantin</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Combs%2C+Stephanie%22">Combs, Stephanie</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> stephanie.combs@tum.de</i><br /><searchLink fieldCode="AR" term="%22Shevtsov%2C+Maxim%22">Shevtsov, Maxim</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<i> sitkov93@yandex.ru</i>
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  Data: <searchLink fieldCode="JN" term="%22Nanomaterials+%282079-4991%29%22">Nanomaterials (2079-4991)</searchLink>. Dec2024, Vol. 14 Issue 24, p2030. 18p.
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  Data: <searchLink fieldCode="DE" term="%22Porous+materials%22">Porous materials</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+nanoparticles%22">Magnetic nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+particles%22">Magnetic particles</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+efficacy%22">Drug efficacy</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+fields%22">Magnetic fields</searchLink><br /><searchLink fieldCode="DE" term="%22Dextran%22">Dextran</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: This study addresses issues in developing spatially controlled magnetic fields for particle guidance, synthesizing biocompatible and chemically stable MNPs and enhancing their specificity to pathological cells through chemical modifications, developing personalized adjustments, and highlighting the potential of tumor-on-a-chip systems, which can simulate tissue environments and assess drug efficacy and dosage in a controlled setting. The research focused on two MNP types, uncoated magnetite nanoparticles (mMNPs) and carboxymethyl dextran coated superparamagnetic nanoparticles (CD-SPIONs), and evaluated their transport properties in microfluidic systems and porous media. The original uncoated mMNPs of bimodal size distribution and the narrow size distribution of the fractions (23 nm and 106 nm by radii) were demonstrated to agglomerate in magnetically driven microfluidic flow, forming a stable stationary web consisting of magnetic fibers within 30 min. CD-SPIONs were demonstrated to migrate in agar gel with the mean pore size equal to or slightly higher than the particle size. The migration velocity was inversely proportional to the size of particles. No compression of the gel was observed under the magnetic field gradient of 40 T/m. In the brain tissue, particles of sizes 220, 350, 820 nm were not penetrating the tissue, while the compression of tissue was observed. The particles of 95 nm size penetrated the tissue at the edge of the sample, and no compression was observed. For all particles, movement through capillary vessels was observed. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.3390/nano14242030
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 18
        StartPage: 2030
    Subjects:
      – SubjectFull: Porous materials
        Type: general
      – SubjectFull: Magnetic nanoparticles
        Type: general
      – SubjectFull: Magnetic particles
        Type: general
      – SubjectFull: Drug efficacy
        Type: general
      – SubjectFull: Magnetic fields
        Type: general
      – SubjectFull: Dextran
        Type: general
    Titles:
      – TitleFull: Magnetically Controlled Transport of Nanoparticles in Solid Tumor Tissues and Porous Media Using a Tumor-on-a-Chip Format.
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              Text: Dec2024
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