Unlocking the Hidden Depths: Multi-Modal Integration of Imaging Mass Spectrometry-Based and Molecular Imaging Techniques.
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| Title: | Unlocking the Hidden Depths: Multi-Modal Integration of Imaging Mass Spectrometry-Based and Molecular Imaging Techniques. |
|---|---|
| Authors: | Akbari, Behnaz1 (AUTHOR) bakbari@purdue.edu, Huber, Bertrand Russell2,3,4,5,6 (AUTHOR), Sherman, Janet Hope2 (AUTHOR) jhsherm@bu.edu |
| Source: | Critical Reviews in Analytical Chemistry. 2025, Vol. 55 Issue 1, p109-138. 30p. |
| Subjects: | Magnetic resonance imaging, Desorption electrospray ionization, Positron emission tomography, Nuclear magnetic resonance spectroscopy, Laser spectroscopy, Ion mobility |
| Abstract: | Multimodal imaging (MMI) has emerged as a powerful tool in clinical research, combining different imaging modes to acquire comprehensive information and enabling scientists and surgeons to study tissue identification, localization, metabolic activity, and molecular discovery, thus aiding in disease progression analysis. While multimodal instruments are gaining popularity, challenges such as non-standardized characteristics, custom software, inadequate commercial support, and integration issues with other instruments need to be addressed. The field of multimodal imaging or multiplexed imaging allows for simultaneous signal reproduction from multiple imaging strategies. Intraoperatively, MMI can be integrated into frameless stereotactic surgery. Recent developments in medical imaging modalities such as magnetic resonance imaging (MRI), and Positron Emission Topography (PET) have brought new perspectives to multimodal imaging, enabling early cancer detection, molecular tracking, and real-time progression monitoring. Despite the evidence supporting the role of MMI in surgical decision-making, there is a need for comprehensive studies to validate and perform integration at the intersection of multiple imaging technologies. They were integrating mass spectrometry-based technologies (e.g., imaging mass spectrometry (IMS), imaging mass cytometry (IMC), and Ion mobility mass spectrometry ((IM-IM) with medical imaging modalities, offering promising avenues for molecular discovery and clinical applications. This review emphasizes the potential of multi-omics approaches in tissue mapping using MMI integrated into desorption electrospray ionization (DESI) and matrix-assisted laser desorption ionization (MALDI), allowing for sequential analyses of the same section. By addressing existing knowledge gaps, this review encourages future research endeavors toward multi-omics approaches, providing a roadmap for future research and enhancing the value of MMI in molecular pathology for diagnosis. [ABSTRACT FROM AUTHOR] |
| Copyright of Critical Reviews in Analytical Chemistry is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: egs DbLabel: Engineering Source An: 182024473 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Unlocking the Hidden Depths: Multi-Modal Integration of Imaging Mass Spectrometry-Based and Molecular Imaging Techniques. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Akbari%2C+Behnaz%22">Akbari, Behnaz</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> bakbari@purdue.edu</i><br /><searchLink fieldCode="AR" term="%22Huber%2C+Bertrand+Russell%22">Huber, Bertrand Russell</searchLink><relatesTo>2,3,4,5,6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sherman%2C+Janet+Hope%22">Sherman, Janet Hope</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> jhsherm@bu.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Critical+Reviews+in+Analytical+Chemistry%22">Critical Reviews in Analytical Chemistry</searchLink>. 2025, Vol. 55 Issue 1, p109-138. 30p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Desorption+electrospray+ionization%22">Desorption electrospray ionization</searchLink><br /><searchLink fieldCode="DE" term="%22Positron+emission+tomography%22">Positron emission tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Nuclear+magnetic+resonance+spectroscopy%22">Nuclear magnetic resonance spectroscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Laser+spectroscopy%22">Laser spectroscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Ion+mobility%22">Ion mobility</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Multimodal imaging (MMI) has emerged as a powerful tool in clinical research, combining different imaging modes to acquire comprehensive information and enabling scientists and surgeons to study tissue identification, localization, metabolic activity, and molecular discovery, thus aiding in disease progression analysis. While multimodal instruments are gaining popularity, challenges such as non-standardized characteristics, custom software, inadequate commercial support, and integration issues with other instruments need to be addressed. The field of multimodal imaging or multiplexed imaging allows for simultaneous signal reproduction from multiple imaging strategies. Intraoperatively, MMI can be integrated into frameless stereotactic surgery. Recent developments in medical imaging modalities such as magnetic resonance imaging (MRI), and Positron Emission Topography (PET) have brought new perspectives to multimodal imaging, enabling early cancer detection, molecular tracking, and real-time progression monitoring. Despite the evidence supporting the role of MMI in surgical decision-making, there is a need for comprehensive studies to validate and perform integration at the intersection of multiple imaging technologies. They were integrating mass spectrometry-based technologies (e.g., imaging mass spectrometry (IMS), imaging mass cytometry (IMC), and Ion mobility mass spectrometry ((IM-IM) with medical imaging modalities, offering promising avenues for molecular discovery and clinical applications. This review emphasizes the potential of multi-omics approaches in tissue mapping using MMI integrated into desorption electrospray ionization (DESI) and matrix-assisted laser desorption ionization (MALDI), allowing for sequential analyses of the same section. By addressing existing knowledge gaps, this review encourages future research endeavors toward multi-omics approaches, providing a roadmap for future research and enhancing the value of MMI in molecular pathology for diagnosis. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Critical Reviews in Analytical Chemistry is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/10408347.2023.2266838 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 30 StartPage: 109 Subjects: – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Desorption electrospray ionization Type: general – SubjectFull: Positron emission tomography Type: general – SubjectFull: Nuclear magnetic resonance spectroscopy Type: general – SubjectFull: Laser spectroscopy Type: general – SubjectFull: Ion mobility Type: general Titles: – TitleFull: Unlocking the Hidden Depths: Multi-Modal Integration of Imaging Mass Spectrometry-Based and Molecular Imaging Techniques. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Akbari, Behnaz – PersonEntity: Name: NameFull: Huber, Bertrand Russell – PersonEntity: Name: NameFull: Sherman, Janet Hope IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: 2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 10408347 Numbering: – Type: volume Value: 55 – Type: issue Value: 1 Titles: – TitleFull: Critical Reviews in Analytical Chemistry Type: main |
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