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Mechanics of ascending aortic aneurysms based on a modulus of elasticity dependent on aneurysm diameter and pressure.

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Title: Mechanics of ascending aortic aneurysms based on a modulus of elasticity dependent on aneurysm diameter and pressure.
Authors: Manopoulos, Christos1 (AUTHOR) manopoul@central.ntua.gr, Seferlis, Konstantinos1 (AUTHOR), Raptis, Anastasios1 (AUTHOR), Kouerinis, Ilias2 (AUTHOR), Mathioulakis, Dimitrios1,3 (AUTHOR)
Source: Computer Methods in Biomechanics & Biomedical Engineering. Feb2025, Vol. 28 Issue 2, p238-253. 16p.
Subjects: Ascending aorta aneurysms, Thoracic aneurysms, Elastic modulus, Young's modulus, Hypertension
Abstract: The mechanical stresses and strains are examined, in ascending thoracic aortic aneurysm (aTAA) models, in a patient-specific aTAA as well as in healthy thoracic aortic models, via Finite Element Analysis. The aneurysms are assumed spherical, 1.5 mm thick, with diameters between 47 mm and 80 mm, eccentrically positioned. The geometry and wall thickness distribution of the aorta along its length are based on open literature data for an average patient age of 66.25 years, accounting for the Body Surface Area (BSA) parameter. The vessel wall material is assumed isotropic and incompressible, with its Young's modulus varying with the aneurysm diameter and the applied intraluminal pressure (120 mmHg to 240 mmHg). In the aTAAs, peak stresses were found to increase nonlinearly with aneurysm diameter (for a given pressure) tending to reach a plateau, appearing at the proximal area of the aneurysm, whereas lower stresses were found at its distal part and even smaller at the aneurysm maximum diameter. Regarding the patient-specific aTAA model, the peak stresses appeared at the distal part of the aneurysm where a tear of the intima layer was detected during surgical intervention. Peak strains exhibited for each pressure a maximum at a certain aneurysm diameter beyond which they dropped so that essentially the vessel wall's distensibility was thus reduced. Examining more than 100 geometry cases and employing a failure stress criterion, the rupture diameter thresholds were estimated to be 65, 52.5, 50 and 47.5 mm for a pressure of 120, 160, 200 and 240 mmHg respectively. [ABSTRACT FROM AUTHOR]
Copyright of Computer Methods in Biomechanics & Biomedical Engineering is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
An: 182209718
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PubTypeId: academicJournal
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Mechanics of ascending aortic aneurysms based on a modulus of elasticity dependent on aneurysm diameter and pressure.
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  Data: <searchLink fieldCode="AR" term="%22Manopoulos%2C+Christos%22">Manopoulos, Christos</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> manopoul@central.ntua.gr</i><br /><searchLink fieldCode="AR" term="%22Seferlis%2C+Konstantinos%22">Seferlis, Konstantinos</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Raptis%2C+Anastasios%22">Raptis, Anastasios</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kouerinis%2C+Ilias%22">Kouerinis, Ilias</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mathioulakis%2C+Dimitrios%22">Mathioulakis, Dimitrios</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Computer+Methods+in+Biomechanics+%26+Biomedical+Engineering%22">Computer Methods in Biomechanics & Biomedical Engineering</searchLink>. Feb2025, Vol. 28 Issue 2, p238-253. 16p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Ascending+aorta+aneurysms%22">Ascending aorta aneurysms</searchLink><br /><searchLink fieldCode="DE" term="%22Thoracic+aneurysms%22">Thoracic aneurysms</searchLink><br /><searchLink fieldCode="DE" term="%22Elastic+modulus%22">Elastic modulus</searchLink><br /><searchLink fieldCode="DE" term="%22Young's+modulus%22">Young's modulus</searchLink><br /><searchLink fieldCode="DE" term="%22Hypertension%22">Hypertension</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The mechanical stresses and strains are examined, in ascending thoracic aortic aneurysm (aTAA) models, in a patient-specific aTAA as well as in healthy thoracic aortic models, via Finite Element Analysis. The aneurysms are assumed spherical, 1.5 mm thick, with diameters between 47 mm and 80 mm, eccentrically positioned. The geometry and wall thickness distribution of the aorta along its length are based on open literature data for an average patient age of 66.25 years, accounting for the Body Surface Area (BSA) parameter. The vessel wall material is assumed isotropic and incompressible, with its Young's modulus varying with the aneurysm diameter and the applied intraluminal pressure (120 mmHg to 240 mmHg). In the aTAAs, peak stresses were found to increase nonlinearly with aneurysm diameter (for a given pressure) tending to reach a plateau, appearing at the proximal area of the aneurysm, whereas lower stresses were found at its distal part and even smaller at the aneurysm maximum diameter. Regarding the patient-specific aTAA model, the peak stresses appeared at the distal part of the aneurysm where a tear of the intima layer was detected during surgical intervention. Peak strains exhibited for each pressure a maximum at a certain aneurysm diameter beyond which they dropped so that essentially the vessel wall's distensibility was thus reduced. Examining more than 100 geometry cases and employing a failure stress criterion, the rupture diameter thresholds were estimated to be 65, 52.5, 50 and 47.5 mm for a pressure of 120, 160, 200 and 240 mmHg respectively. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Computer Methods in Biomechanics & Biomedical Engineering is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1080/10255842.2023.2285722
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      – Code: eng
        Text: English
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        PageCount: 16
        StartPage: 238
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        Type: general
      – SubjectFull: Thoracic aneurysms
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      – SubjectFull: Elastic modulus
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      – SubjectFull: Young's modulus
        Type: general
      – SubjectFull: Hypertension
        Type: general
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      – TitleFull: Mechanics of ascending aortic aneurysms based on a modulus of elasticity dependent on aneurysm diameter and pressure.
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            NameFull: Manopoulos, Christos
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              M: 02
              Text: Feb2025
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              Y: 2025
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