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Biological evaluation of hydroxyapatite zirconium nanoparticle as a potential radiosensitizer for lung cancer X-ray induced photodynamic therapy.

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Title: Biological evaluation of hydroxyapatite zirconium nanoparticle as a potential radiosensitizer for lung cancer X-ray induced photodynamic therapy.
Authors: Kurniawan, Ahmad1 (AUTHOR) ahma092@brin.go.id, Mahendra, Isa1 (AUTHOR), Febrian, Muhamad Basit1 (AUTHOR), Utama, Marhendra Satria2 (AUTHOR), Gunadi, Julia Windi3 (AUTHOR), Wahyudianingsih, Roro4 (AUTHOR), Lesmana, Ronny5 (AUTHOR), Halimah, Iim1 (AUTHOR), Sriyani, Maula Eka1 (AUTHOR), Widyasari, Eva Maria1 (AUTHOR), Wibawa, Teguh Hafiz Ambar1 (AUTHOR), Rizaludin, Asep1 (AUTHOR), Kusumaningrum, Crhisterra Ellen1 (AUTHOR), Syarif, Dani Gustaman6 (AUTHOR)
Source: Applied Radiation & Isotopes. Mar2025, Vol. 217, pN.PAG-N.PAG. 1p.
Subjects: Photodynamic therapy, Acute toxicity testing, Reactive oxygen species, Pathological physiology, Cell imaging
Abstract: Photodynamic therapy has been recognized as a viable approach for lung cancer treatment. Some photosensitizer agents are known as X-ray sensitive and could improve radiotherapy efficacy. The use of nanoparticles for drug delivery and as photosensitizer agents offers various advantages because of their rapid cellular accumulation and distribution into target organs. On the other hand, several nanoparticles could trigger adverse effects during cancer treatment. In this article, the biological study of hydroxyapatite zirconium nanoparticles (HApZr) as photosensitizer candidates for X-ray-induced photodynamic therapy has been demonstrated in vitro and in vivo. This nanoparticle increased the intracellular reactive oxygen species (ROS) levels after the delivery of ionizing radiation at 5 Gy to a cancer cell line and showed higher cytotoxicity compared to non-irradiated treatment. In vitro cellular uptake based on cell imaging also indicated a promising intake and an ability to kill cancer cells. Subsequently, an in vivo evaluation using orthotopic lung cancer mouse models also showed their good accumulation in target organs, with lower accumulation in normal lung tissue. Moreover, studies of acute toxicity showed that a dose of 50 μg/mL yielded minor pathological changes on histological evaluations, which were supported by a biochemical analysis. In addition, HApZr nanoparticles also increase TNF-α which enhancing the cytotoxic effect after irradiation. Finally, these findings were important for further investigation of the clinical application of these HApZr nanoparticles for the treatment of patients with lung cancer. [Display omitted] [ABSTRACT FROM AUTHOR]
Copyright of Applied Radiation & Isotopes is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
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Header DbId: egs
DbLabel: Engineering Source
An: 182321534
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Biological evaluation of hydroxyapatite zirconium nanoparticle as a potential radiosensitizer for lung cancer X-ray induced photodynamic therapy.
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  Data: <searchLink fieldCode="AR" term="%22Kurniawan%2C+Ahmad%22">Kurniawan, Ahmad</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> ahma092@brin.go.id</i><br /><searchLink fieldCode="AR" term="%22Mahendra%2C+Isa%22">Mahendra, Isa</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Febrian%2C+Muhamad+Basit%22">Febrian, Muhamad Basit</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Utama%2C+Marhendra+Satria%22">Utama, Marhendra Satria</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gunadi%2C+Julia+Windi%22">Gunadi, Julia Windi</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wahyudianingsih%2C+Roro%22">Wahyudianingsih, Roro</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lesmana%2C+Ronny%22">Lesmana, Ronny</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Halimah%2C+Iim%22">Halimah, Iim</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sriyani%2C+Maula+Eka%22">Sriyani, Maula Eka</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Widyasari%2C+Eva+Maria%22">Widyasari, Eva Maria</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wibawa%2C+Teguh+Hafiz+Ambar%22">Wibawa, Teguh Hafiz Ambar</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rizaludin%2C+Asep%22">Rizaludin, Asep</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kusumaningrum%2C+Crhisterra+Ellen%22">Kusumaningrum, Crhisterra Ellen</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Syarif%2C+Dani+Gustaman%22">Syarif, Dani Gustaman</searchLink><relatesTo>6</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Applied+Radiation+%26+Isotopes%22">Applied Radiation & Isotopes</searchLink>. Mar2025, Vol. 217, pN.PAG-N.PAG. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Photodynamic+therapy%22">Photodynamic therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Acute+toxicity+testing%22">Acute toxicity testing</searchLink><br /><searchLink fieldCode="DE" term="%22Reactive+oxygen+species%22">Reactive oxygen species</searchLink><br /><searchLink fieldCode="DE" term="%22Pathological+physiology%22">Pathological physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+imaging%22">Cell imaging</searchLink>
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  Label: Abstract
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  Data: Photodynamic therapy has been recognized as a viable approach for lung cancer treatment. Some photosensitizer agents are known as X-ray sensitive and could improve radiotherapy efficacy. The use of nanoparticles for drug delivery and as photosensitizer agents offers various advantages because of their rapid cellular accumulation and distribution into target organs. On the other hand, several nanoparticles could trigger adverse effects during cancer treatment. In this article, the biological study of hydroxyapatite zirconium nanoparticles (HApZr) as photosensitizer candidates for X-ray-induced photodynamic therapy has been demonstrated in vitro and in vivo. This nanoparticle increased the intracellular reactive oxygen species (ROS) levels after the delivery of ionizing radiation at 5 Gy to a cancer cell line and showed higher cytotoxicity compared to non-irradiated treatment. In vitro cellular uptake based on cell imaging also indicated a promising intake and an ability to kill cancer cells. Subsequently, an in vivo evaluation using orthotopic lung cancer mouse models also showed their good accumulation in target organs, with lower accumulation in normal lung tissue. Moreover, studies of acute toxicity showed that a dose of 50 μg/mL yielded minor pathological changes on histological evaluations, which were supported by a biochemical analysis. In addition, HApZr nanoparticles also increase TNF-α which enhancing the cytotoxic effect after irradiation. Finally, these findings were important for further investigation of the clinical application of these HApZr nanoparticles for the treatment of patients with lung cancer. [Display omitted] [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Applied Radiation & Isotopes is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.apradiso.2024.111615
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      – Code: eng
        Text: English
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      – SubjectFull: Photodynamic therapy
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      – SubjectFull: Acute toxicity testing
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      – SubjectFull: Reactive oxygen species
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      – SubjectFull: Pathological physiology
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      – SubjectFull: Cell imaging
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      – TitleFull: Biological evaluation of hydroxyapatite zirconium nanoparticle as a potential radiosensitizer for lung cancer X-ray induced photodynamic therapy.
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              Text: Mar2025
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