Comparative efficacy and safety of the novel Picosecond Alexandrite Laser and the traditional combined Q-switched and long-pulse Nd: YAG lasers in melasma treatment: a randomized evaluator-blinded trial.
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| Title: | Comparative efficacy and safety of the novel Picosecond Alexandrite Laser and the traditional combined Q-switched and long-pulse Nd: YAG lasers in melasma treatment: a randomized evaluator-blinded trial. |
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| Authors: | Liang, Surong1,2 (AUTHOR) surong_liang@foxmail.com, Shang, Shuai3 (AUTHOR) shangshuai1997@163.com, Tan, Ansheng2 (AUTHOR) 435343348@qq.com, Zhang, Wensi4 (AUTHOR) 1911153@mail.ccmu.edu.cn, Zhou, Boyang2 (AUTHOR) zbyy68@163.com, Mei, Xueling2 (AUTHOR) meixueling@ccmu.edu.cn, Li, Linfeng2 (AUTHOR) zoonli@sina.com |
| Source: | Lasers in Medical Science. 1/23/2025, Vol. 40 Issue 1, p1-9. 9p. |
| Subjects: | Nd-YAG lasers, YAG lasers, Q-switched lasers, Laser therapy, Patient satisfaction |
| Abstract: | Melasma significantly impacts life quality, and while various laser therapies show promise, rigorous comparative studies, especially between the novel Picosecond Alexandrite Laser (PSAL) and the traditional combined modality of Q-switched and Long-pulse Nd: YAG Lasers (QLNYL), are notably lacking. This study aims to fill this gap by evaluating the efficacy and safety of these modalities, providing insights into their comparative advantages for clinical practice. In a prospective, evaluator-blinded study, 40 participants with Fitzpatrick Skin Types (FST) III and IV underwent three treatment sessions at four-week intervals with either PSAL or QLNYL. Efficacy was primarily assessed by changes in Melasma Area and Severity Index (MASI) scores at baseline, 4, 8, 12, and 24 weeks, along with patient satisfaction evaluations at the 12- and 24-week marks, and safety assessments conducted throughout the study. Both groups experienced significant reductions in MASI scores post-treatment. Overall, the improvement in MASI scores in the QLNYL group significantly surpassed that in the PSAL group (P = 0.010). Patient satisfaction was comparably high between groups, and no significant differences were noted in safety profiles. The PSAL group showed a slightly higher incidence of adverse reactions (not significant) and significantly higher pain scores (P = 0.018). Recurrence rates at the 24-week follow-up were 10.5% for PSAL and 0% for QLNYL, with no significant difference. Both PSAL and QLNYL proved effective in treating melasma, with the traditional combined modality of QLNYL demonstrating superior efficacy in FST III-IV. Safety profiles were similar comparable. [ABSTRACT FROM AUTHOR] |
| Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: egs DbLabel: Engineering Source An: 182409403 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Comparative efficacy and safety of the novel Picosecond Alexandrite Laser and the traditional combined Q-switched and long-pulse Nd: YAG lasers in melasma treatment: a randomized evaluator-blinded trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Liang%2C+Surong%22">Liang, Surong</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> surong_liang@foxmail.com</i><br /><searchLink fieldCode="AR" term="%22Shang%2C+Shuai%22">Shang, Shuai</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> shangshuai1997@163.com</i><br /><searchLink fieldCode="AR" term="%22Tan%2C+Ansheng%22">Tan, Ansheng</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> 435343348@qq.com</i><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Wensi%22">Zhang, Wensi</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> 1911153@mail.ccmu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Zhou%2C+Boyang%22">Zhou, Boyang</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> zbyy68@163.com</i><br /><searchLink fieldCode="AR" term="%22Mei%2C+Xueling%22">Mei, Xueling</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> meixueling@ccmu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Li%2C+Linfeng%22">Li, Linfeng</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> zoonli@sina.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Lasers+in+Medical+Science%22">Lasers in Medical Science</searchLink>. 1/23/2025, Vol. 40 Issue 1, p1-9. 9p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Nd-YAG+lasers%22">Nd-YAG lasers</searchLink><br /><searchLink fieldCode="DE" term="%22YAG+lasers%22">YAG lasers</searchLink><br /><searchLink fieldCode="DE" term="%22Q-switched+lasers%22">Q-switched lasers</searchLink><br /><searchLink fieldCode="DE" term="%22Laser+therapy%22">Laser therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+satisfaction%22">Patient satisfaction</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Melasma significantly impacts life quality, and while various laser therapies show promise, rigorous comparative studies, especially between the novel Picosecond Alexandrite Laser (PSAL) and the traditional combined modality of Q-switched and Long-pulse Nd: YAG Lasers (QLNYL), are notably lacking. This study aims to fill this gap by evaluating the efficacy and safety of these modalities, providing insights into their comparative advantages for clinical practice. In a prospective, evaluator-blinded study, 40 participants with Fitzpatrick Skin Types (FST) III and IV underwent three treatment sessions at four-week intervals with either PSAL or QLNYL. Efficacy was primarily assessed by changes in Melasma Area and Severity Index (MASI) scores at baseline, 4, 8, 12, and 24 weeks, along with patient satisfaction evaluations at the 12- and 24-week marks, and safety assessments conducted throughout the study. Both groups experienced significant reductions in MASI scores post-treatment. Overall, the improvement in MASI scores in the QLNYL group significantly surpassed that in the PSAL group (P = 0.010). Patient satisfaction was comparably high between groups, and no significant differences were noted in safety profiles. The PSAL group showed a slightly higher incidence of adverse reactions (not significant) and significantly higher pain scores (P = 0.018). Recurrence rates at the 24-week follow-up were 10.5% for PSAL and 0% for QLNYL, with no significant difference. Both PSAL and QLNYL proved effective in treating melasma, with the traditional combined modality of QLNYL demonstrating superior efficacy in FST III-IV. Safety profiles were similar comparable. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=182409403 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10103-025-04286-1 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 1 Subjects: – SubjectFull: Nd-YAG lasers Type: general – SubjectFull: YAG lasers Type: general – SubjectFull: Q-switched lasers Type: general – SubjectFull: Laser therapy Type: general – SubjectFull: Patient satisfaction Type: general Titles: – TitleFull: Comparative efficacy and safety of the novel Picosecond Alexandrite Laser and the traditional combined Q-switched and long-pulse Nd: YAG lasers in melasma treatment: a randomized evaluator-blinded trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Liang, Surong – PersonEntity: Name: NameFull: Shang, Shuai – PersonEntity: Name: NameFull: Tan, Ansheng – PersonEntity: Name: NameFull: Zhang, Wensi – PersonEntity: Name: NameFull: Zhou, Boyang – PersonEntity: Name: NameFull: Mei, Xueling – PersonEntity: Name: NameFull: Li, Linfeng IsPartOfRelationships: – BibEntity: Dates: – D: 23 M: 01 Text: 1/23/2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 02688921 Numbering: – Type: volume Value: 40 – Type: issue Value: 1 Titles: – TitleFull: Lasers in Medical Science Type: main |
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