Free-breathing 3D phase-resolved functional lung MRI vs breath-hold hyperpolarized 129Xe ventilation MRI in patients with chronic obstructive pulmonary disease and healthy volunteers.
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| Title: | Free-breathing 3D phase-resolved functional lung MRI vs breath-hold hyperpolarized 129Xe ventilation MRI in patients with chronic obstructive pulmonary disease and healthy volunteers. |
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| Authors: | Klimeš, Filip1,2 (AUTHOR), Kern, Agilo Luitger1,2 (AUTHOR), Voskrebenzev, Andreas1,2 (AUTHOR), Gutberlet, Marcel1,2 (AUTHOR), Grimm, Robert3 (AUTHOR), Müller, Robin Aaron1,2 (AUTHOR), Behrendt, Lea1,2 (AUTHOR), Kaireit, Till Frederik1,2 (AUTHOR), Glandorf, Julian1,2 (AUTHOR), Alsady, Tawfik Moher1,2 (AUTHOR), Wacker, Frank1,2 (AUTHOR), Hohlfeld, Jens M.2,4,5 (AUTHOR), Vogel-Claussen, Jens1,2 (AUTHOR) vogel-claussen.jens@mh-hannover.de |
| Source: | European Radiology. Feb2025, Vol. 35 Issue 2, p943-956. 14p. |
| Subjects: | Magnetic resonance imaging, Chronic obstructive pulmonary disease, Functional magnetic resonance imaging, Wilcoxon signed-rank test, Obstructive lung diseases |
| Abstract: | Objectives: 3D phase-resolved functional lung (PREFUL) MRI offers evaluation of pulmonary ventilation without inhalation of contrast agent. This study seeks to compare ventilation maps obtained from 3D PREFUL MRI with a direct ventilation measurement derived from 129Xe MRI in both patients with chronic obstructive pulmonary disease (COPD) and healthy volunteers. Methods: Thirty-one patients with COPD and 12 healthy controls underwent free-breathing 3D PREFUL MRI and breath-hold 129Xe MRI at 1.5 T. For both MRI techniques, ventilation defect (VD) maps were determined and respective ventilation defect percentage (VDP) values were computed. All parameters of both techniques were compared by Spearman correlation coefficient (r) and the differences between VDP values were quantified by Bland–Altman analysis and tested for significance using Wilcoxon signed-rank test. In a regional comparison of VD maps, spatial overlap and Sørensen–Dice coefficients of healthy and defect areas were computed. Results: On a global level, all 3D PREFUL VDP values correlated significantly to VDP measure derived by 129Xe ventilation imaging (all r > 0.65; all p < 0.0001). 129Xe VDP was significantly greater than 3D PREFUL derived VDPRVent (mean bias = 10.5%, p < 0.001) and VDPFVL-CM (mean bias = 11.3%, p < 0.0001) but not for VDPCombined (mean bias = 1.7%, p = 0.70). The total regional agreement of 129Xe and 3D PREFUL VD maps ranged between 60% and 63%. Conclusions: Free-breathing 3D PREFUL MRI showed a strong correlation with breath-hold hyperpolarized 129Xe MRI regarding the VDP values and modest differences in the detection of VDs on a regional level. Clinical relevance statement: 3D PREFUL MRI correlated with 129Xe MRI, unveiling regional differences in COPD defect identification. This proposes 3D PREFUL MRI as a ventilation mapping surrogate, eliminating the need for extra hardware or inhaled gases. Key Points: Current non-invasive evaluation techniques for lung diseases have drawbacks;129Xe MRI is limited by cost and availability. 3D PREFUL MRI correlated with129Xe MRI, with regional differences in identifying COPD defects. 3D PREFUL MRI can provide ventilation mapping without the need for additional hardware or inhaled gases. [ABSTRACT FROM AUTHOR] |
| Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: egs DbLabel: Engineering Source An: 182564605 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Free-breathing 3D phase-resolved functional lung MRI vs breath-hold hyperpolarized <superscript>129</superscript>Xe ventilation MRI in patients with chronic obstructive pulmonary disease and healthy volunteers. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Klimeš%2C+Filip%22">Klimeš, Filip</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kern%2C+Agilo+Luitger%22">Kern, Agilo Luitger</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Voskrebenzev%2C+Andreas%22">Voskrebenzev, Andreas</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gutberlet%2C+Marcel%22">Gutberlet, Marcel</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Grimm%2C+Robert%22">Grimm, Robert</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Müller%2C+Robin+Aaron%22">Müller, Robin Aaron</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Behrendt%2C+Lea%22">Behrendt, Lea</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kaireit%2C+Till+Frederik%22">Kaireit, Till Frederik</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Glandorf%2C+Julian%22">Glandorf, Julian</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Alsady%2C+Tawfik+Moher%22">Alsady, Tawfik Moher</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wacker%2C+Frank%22">Wacker, Frank</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hohlfeld%2C+Jens+M%2E%22">Hohlfeld, Jens M.</searchLink><relatesTo>2,4,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vogel-Claussen%2C+Jens%22">Vogel-Claussen, Jens</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> vogel-claussen.jens@mh-hannover.de</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Feb2025, Vol. 35 Issue 2, p943-956. 14p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Chronic+obstructive+pulmonary+disease%22">Chronic obstructive pulmonary disease</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+magnetic+resonance+imaging%22">Functional magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Wilcoxon+signed-rank+test%22">Wilcoxon signed-rank test</searchLink><br /><searchLink fieldCode="DE" term="%22Obstructive+lung+diseases%22">Obstructive lung diseases</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objectives: 3D phase-resolved functional lung (PREFUL) MRI offers evaluation of pulmonary ventilation without inhalation of contrast agent. This study seeks to compare ventilation maps obtained from 3D PREFUL MRI with a direct ventilation measurement derived from 129Xe MRI in both patients with chronic obstructive pulmonary disease (COPD) and healthy volunteers. Methods: Thirty-one patients with COPD and 12 healthy controls underwent free-breathing 3D PREFUL MRI and breath-hold 129Xe MRI at 1.5 T. For both MRI techniques, ventilation defect (VD) maps were determined and respective ventilation defect percentage (VDP) values were computed. All parameters of both techniques were compared by Spearman correlation coefficient (r) and the differences between VDP values were quantified by Bland–Altman analysis and tested for significance using Wilcoxon signed-rank test. In a regional comparison of VD maps, spatial overlap and Sørensen–Dice coefficients of healthy and defect areas were computed. Results: On a global level, all 3D PREFUL VDP values correlated significantly to VDP measure derived by 129Xe ventilation imaging (all r > 0.65; all p < 0.0001). 129Xe VDP was significantly greater than 3D PREFUL derived VDPRVent (mean bias = 10.5%, p < 0.001) and VDPFVL-CM (mean bias = 11.3%, p < 0.0001) but not for VDPCombined (mean bias = 1.7%, p = 0.70). The total regional agreement of 129Xe and 3D PREFUL VD maps ranged between 60% and 63%. Conclusions: Free-breathing 3D PREFUL MRI showed a strong correlation with breath-hold hyperpolarized 129Xe MRI regarding the VDP values and modest differences in the detection of VDs on a regional level. Clinical relevance statement: 3D PREFUL MRI correlated with 129Xe MRI, unveiling regional differences in COPD defect identification. This proposes 3D PREFUL MRI as a ventilation mapping surrogate, eliminating the need for extra hardware or inhaled gases. Key Points: Current non-invasive evaluation techniques for lung diseases have drawbacks;129Xe MRI is limited by cost and availability. 3D PREFUL MRI correlated with129Xe MRI, with regional differences in identifying COPD defects. 3D PREFUL MRI can provide ventilation mapping without the need for additional hardware or inhaled gases. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00330-024-10893-3 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 14 StartPage: 943 Subjects: – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Chronic obstructive pulmonary disease Type: general – SubjectFull: Functional magnetic resonance imaging Type: general – SubjectFull: Wilcoxon signed-rank test Type: general – SubjectFull: Obstructive lung diseases Type: general Titles: – TitleFull: Free-breathing 3D phase-resolved functional lung MRI vs breath-hold hyperpolarized 129Xe ventilation MRI in patients with chronic obstructive pulmonary disease and healthy volunteers. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Klimeš, Filip – PersonEntity: Name: NameFull: Kern, Agilo Luitger – PersonEntity: Name: NameFull: Voskrebenzev, Andreas – PersonEntity: Name: NameFull: Gutberlet, Marcel – PersonEntity: Name: NameFull: Grimm, Robert – PersonEntity: Name: NameFull: Müller, Robin Aaron – PersonEntity: Name: NameFull: Behrendt, Lea – PersonEntity: Name: NameFull: Kaireit, Till Frederik – PersonEntity: Name: NameFull: Glandorf, Julian – PersonEntity: Name: NameFull: Alsady, Tawfik Moher – PersonEntity: Name: NameFull: Wacker, Frank – PersonEntity: Name: NameFull: Hohlfeld, Jens M. – PersonEntity: Name: NameFull: Vogel-Claussen, Jens IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 09387994 Numbering: – Type: volume Value: 35 – Type: issue Value: 2 Titles: – TitleFull: European Radiology Type: main |
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